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Dive into the research topics where Steven Robert Miller is active.

Publication


Featured researches published by Steven Robert Miller.


Bioorganic & Medicinal Chemistry | 2003

Synthesis and structure–Activity relationship of 2-amino-3-heteroaryl-quinoxalines as non-peptide, small-Molecule antagonists for interleukin-8 receptor

Jie Jack Li; Kenneth G. Carson; Bharat Kalidas Trivedi; Wen Song Yue; Qing Ye; Roberta A Glynn; Steven Robert Miller; David T. Connor; Bruce D. Roth; Jay R. Luly; Joseph E Low; David J Heilig; Weixing Yang; Shixin Qin; Stephen W. Hunt

Interleukin-8 modulation is implicated in many inflammatory and cancer diseases. Starting from a mass-screening hit, the synthesis and structure-activity relationship of 2-amino-3-heteroarylquinoxalines as non-peptide, small molecule interleukine-8 receptor antagonists have been developed. The optimized derivatives, PD 0210293 (13y) and PD 0220245 (13r), show inhibition of both IL-8 receptor binding and IL-8-mediated neutrophil chemotaxis.


Journal of Medicinal Chemistry | 1997

Chromeno[3,4-c]pyridin-5-ones: Selective Human Dopamine D4 Receptor Antagonists as Potential Antipsychotic Agents

Paul C. Unangst; Thomas Capiris; David T. Connor; Thomas G. Heffner; Robert G. MacKenzie; Steven Robert Miller; and Thomas A. Pugsley; Lawrence D. Wise


Bioorganic & Medicinal Chemistry Letters | 2007

Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors

Jeffrey A. Pfefferkorn; Yuntao Song; Kuai Lin Sun; Steven Robert Miller; Bharat Kalidas Trivedi; Chulho Choi; Roderick Joseph Sorenson; Larry D. Bratton; Paul C. Unangst; Scott D. Larsen; Toni Jo Poel; Xue-Min Cheng; Chitase Lee; Noe Erasga; Bruce Auerbach; Valerie Askew; Lisa Dillon; Jeffrey C. Hanselman; Zhiwu Lin; Gina H. Lu; Andrew Robertson; Karl Olsen; Thomas Mertz; Catherine Sekerke; Alexander Pavlovsky; Melissa S. Harris; Graeme Bainbridge; Nicole Caspers; Huifen Chen; Matthias Eberstadt


Tetrahedron | 2007

Development of a practical synthesis of novel, pyrrole-based HMG-CoA reductase inhibitors

Jeffrey A. Pfefferkorn; Daniel Merritt Bowles; William Kissel; David C. Boyles; Chulho Choi; Scott D. Larsen; Yuntao Song; Kuai Lin Sun; Steven Robert Miller; Bharat Kalidas Trivedi


Archive | 1999

Method of treating psychosis and schizophrenia

Thomas Capiris; David T. Connor; Steven Robert Miller; Paul C. Unangst; Lawrence D. Wise


Journal of Medicinal Chemistry | 1997

(Aryloxy)alkylamines as selective human dopamine D4 receptor antagonists: potential antipsychotic agents.

Paul C. Unangst; Thomas Capiris; David T. Connor; Robert Doubleday; Thomas G. Heffner; Robert G. MacKenzie; Steven Robert Miller; Thomas A. Pugsley; Lawrence D. Wise


Archive | 2004

N-alkyl pyrroles as hmg-coa reductase inhibitors

Larry D. Bratton; Xue-Min Cheng; Chitase Lee; Steven Robert Miller; Jeffrey A. Pfefferkorn; Toni-jo Poel; Roderick Joseph Sorenson; Yuntao Song; Kuai-Lin Sun; Bharat Kalidas Trivedi; Paul C. Unangst


Archive | 1992

2-carbonyl substituted-5-hydroxy-1, 3-pyrimidines as antiinflammatory agents

Thomas R. Belliotti; David T. Connor; Catherine Rose Kostlan; Steven Robert Miller


Archive | 1997

Compounds and method of treating psychosis and schizophrenia

David T. Connor; Stephen J. Johnson; Suzanne Ross Kesten; Steven Robert Miller; Paul C. Unangst; Lawrence D. Wise


Archive | 2003

MCP-1 receptor antagonists and methods of use thereof

Larry D. Bratton; Alexander James Bridges; David T. Connor; Steven Robert Miller; Yuntao Song; Kuai-Lin Sun; Bharat Kalidas Trivedi; Paul C. Unangst

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