Subhash C. Bhatia

Ultrasonic velocities, isentropic compressibilities and excess molar volumes of octan-1-ol with chloroform, 1,2-dichloroethane and 1,1,2,2-tetrachloroethane at 298.15 and 308.15 K

Densities (ρ), and ultrasonic velocities (u) of binary mixtures of octan-1-ol with chloroform, 1,2-dichloroethane, and 1,1,2,2-tetrachloroethane (TCE) have been measured over the entire range of composition at 298.15 and 308.15 K and at atmospheric pressure. From the experimental values of density and ultrasonic velocity, the excess molar volumes (V E), deviations in ultrasonic velocity (Δu), intermolecular free lengths (L f), mean molecular radii (r), molar sound velocities (Rm ), acoustic impedances (Z), excess isentropic compressibilities ( ), excess intermolecular free lengths ( ) and excess acoustic impedances (Z E) have been calculated. These excess functions have been fitted to the Redlich–Kister polynomial equation to derive the binary coefficients and the standard errors between the experimental and the calculated quantities. The experimental ultrasonic velocities have been analysed in terms of Nomoto (N), Van Dael (VD), Jacobsons free length theory, Schaaffs collision factor theory and thermoacoustical parameters.

α,α-Dibromoacetophenones mediated synthesis of some new 7H-7-alkoxy-3-alkyl/phenyl-6-aryl-s-triazolo[3,4-b][1,3,4]thiadiazines and their antimicrobial evaluation

A series of new 7H-7-alkoxy-3-alkyl/phenyl-6-aryl-s-triazolo[3,4-b][1,3,4]thiadiazines (3, 4) were synthesized by the reaction of various α,α-dibromoacetophenones 1 with 3-alkyl/phenyl-4-amino-5-mercapto-s-triazoles (2) in different alcoholic solvents in good yields. All the newly synthesized compounds (3, 4) were screened for their in vitro antibacterial and antifungal activity. Biological activities of these compounds were compared with those of the commercially available antibiotic, ciprofloxacin and antifungal agent, amphotericin-B. The title compounds showed good activity against the Gram-positive bacteria, Staphylococcus aureus and Bacillus subtilis and the yeasts, Saccharomyces cerevisiae and Candida albicans.