Subhash P. Chavan

Use of solid superacid (sulphated SnO2) as efficient catalyst in tacile transesterification of ketoesters

Facile one to one transesterification of ketoesters catalysed by solid superacid (sulphated SnO2) is described.

INTERCONVERSION OF OXATHIOLANES AND CARBONYLS UNDER ESSENTIALLY IDENTICAL CONDITIONS

Abstract A catalytic, non-aqueous protocol for the interconversion of oxathiolanes and carbonyl compounds at room temperature is described.

Zinc mediated transesterification of β-ketoesters and coumarin synthesis

The transesterification of ketoesters using zinc and iodine is described. The reaction has been done on a variety of alcohols and phenols. Alcohols furnish transesterified products whereas phenols gave 4-methylcoumarins. The method is highly promising compared with existing methods.

Fluconazole analogues containing 2H-1,4-benzothiazin-3(4H)-one or 2H-1,4-benzoxazin-3(4H)-one moieties, a novel class of anti-Candida agents

As a part of our program to develop new antifungal agents, a series of fluconazole analogues was designed and synthesized wherein one of the triazole moieties in fluconazole was replaced with 2H-1,4-benzothiazin-3(4H)-one or 2H-1,4-benzoxazin-3(4H)-one moiety. The new chemical entities thus synthesized were screened against various fungi and it was observed that the compounds 4a and 4i are potent inhibitors of Candida strains. The structure-activity relationship for these compounds is discussed.

An Efficient Oxidation of 1,4-Dihydropyridines Using Aqueous tert.-Butylhydroperoxide

Abstract Aromatization of 4-substituted 1,4-dihydro-2,6-dimethyl-3,5-pyridine dicarboxylate using aqueous tert.-butylhydroperoxide in 74–87% yield has been achieved.

Synthesis of lavendamycin

A regiospecific and convergent synthesis of Lavendamycin (1) starting from 8-hydroxyquinoline and indole via Bischler-Napieralski cyclisation is described.

TRANSESTERIFICATION OF KETOESTERS USING AMBERLYST-15

A facile one-to-one transesterification of ketoesters by Amberlyst-15 is described.

An Efficient Co(II) Catalyzed Auto Oxidation of 1,4-Dihydropyridines

Abstract An efficient Co(II) catalyzed auto oxidation of 1,4-dihydropyridines to pyridines in good to excellent yield is described.

An efficient entry into butenolides: Synthesis of (±) mintlactone

Abstract Osmylation of β,γ-unsaturated esters and acid catalysed cyclisation of the resultant diols generate butenolides in high yields.

Sn-β molecular sieve catalysed Baeyer-Villiger oxidation in ionic liquid at room temperature

Efficient oxidation of aryl ketones to esters at room temperature with 30% aqueous H2O2 and catalytic Sn-β-molecular sieve in ionic liquid was established.