Suk-Kyung Kim
Kyungpook National University
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Publication
Featured researches published by Suk-Kyung Kim.
Archives of Pharmacal Research | 2004
In-Hye Park; Shin-Kyo Chung; Kyung-Bok Lee; Yung-Choon Yoo; Suk-Kyung Kim; Geum-Soog Kim; Kyung-Sik Song
In the course of screening for reactive oxygen species scavengers from natural products, an antioxidant was isolated from the mycelial culture broth ofPhellinus linteus and identified as hispidin. The hispidin content was reached its maximum level at 12 days after onset of inoculation. About 2.5 mg/mL of hispidin was produced byP. linteus in a yeast-malt medium (pH 5.8, 25°C). Hispidin inhibited 22.6 and 56.8% of the super oxide anion radical, 79.4 and 95.3% of the hydroxyl radical, and 28.1 and 85.5% of the DPPH radical at 0.1 and 1.0 mM, respectively. The positive control oc-tocopherol scavenged 25.6 and 60.3%, 74.6 and 96.3%, and 32.7 and 77.5% of each radical, respectively, at the same concentrations. However, hispidin showed no significant activity on the hydrogen peroxide radical.
Journal of Dental Research | 2017
Ji-Woong Choi; Suk-Kyung Kim; Sung-Kook Hong; Hye-Sung Lee
MicroRNAs (miRNAs) have been shown to be major regulators of eukaryotic gene expression. However, bacterial RNAs comparable in size to eukaryotic miRNAs (18–22 nucleotides) have received little attention. Recently, a novel class of small RNAs similar in size to miRNAs (miRNA-size, small RNAs or msRNAs) have also been found in several bacteria. Like miRNAs, msRNAs are approximately 15 to 25 nucleotides in length, and their precursors are predicted to form a hairpin loop secondary structure. Here, we identified msRNAs in the periodontal pathogens Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and Treponema denticola. We examined these msRNAs using a deep sequencing method and characterized dozens of msRNAs through bioinformatic analysis. Highly expressed msRNAs were selected for further validation. The findings suggest that this class of small RNAs is well conserved across the domains of life. Indeed, msRNAs secreted via bacterial outer membrane vesicles (OMVs) were detected. The ability of bacterial OMVs to deliver RNAs into eukaryotic cells was also observed. These msRNAs in OMVs allowed us to identify their potential human immune-related target genes. Furthermore, we found that exogenous msRNAs could suppress expression of certain cytokines in Jurkat T cells. We propose msRNAs may function as novel bacterial signaling molecules that mediate bacteria-to-human interactions. Furthermore, this study may provide fresh insight into bacterial pathogenic mechanisms of periodontal diseases.
Korean Journal of Food Preservation | 2008
Hye-Ryun Lee; Bo-Ra Jung; Joo-Young Park; In-Wook Hwang; Suk-Kyung Kim; Jong-Uck Choi; Sang-Han Lee; Shin-Kyo Chung
Polyhedron | 2007
Sujit Dutta; Suk-Kyung Kim; Daksha B. Patel; Tae-Jeong Kim; Yongmin Chang
Korean Journal of Food Preservation | 2008
In-Wook Hwang; Hye-Ryun Lee; Suk-Kyung Kim; Hu-Zhe Zheng; Jong-Uck Choi; Sang-Han Lee; Suk-Hee Lee; Shin-Kyo Chung
Bulletin of The Korean Chemical Society | 2006
Sujit Dutta; Suk-Kyung Kim; Eun Jung Lee; Tae-Jeong Kim; Duk-Sik Kang; Yongmin Chang; Sang Ook Kang; Won-Sik Han
Applied Biological Chemistry | 2010
Hu-Zhe Zheng; In-Wook Hwang; Suk-Kyung Kim; Sang-Han Lee; Shin-Kyo Chung
Journal of The Korean Society for Applied Biological Chemistry | 2005
Suk-Kyung Kim; So-Youn Ban; Jun-Sung Kim; Shin-Kyo Chung
Korean Journal of Food Science and Technology | 2003
Suk-Kyung Kim; Gee-Dong Lee; Shin-Kyo Chung
Korean Journal of Food Preservation | 2010
Jin-Soon Park; In-Wook Hwang; Hu-Zhe Zheng; Suk-Kyung Kim; Shin-Kyo Chung