Sumit Raniga

The biology of rotator cuff healing.

Despite advances in surgical reconstruction of chronic rotator cuff (RC) tears leading to improved clinical outcomes, failure rates of 13-94% have been reported. Reasons for this rather high failure rate include compromised healing at the bone-tendon interface, as well as the musculo-tendinous changes that occur after RC tears, namely retraction and muscle atrophy, as well as fatty infiltration. Significant research efforts have focused on gaining a better understanding of these pathological changes in order to design effective therapeutic solutions. Biological augmentation, including the application of different growth factors, platelet concentrates, cells, scaffolds and various drugs, or a combination of the above have been studied. It is important to note that instead of a physiological enthesis, an abundance of scar tissue is formed. Even though cytokines have demonstrated the potential to improve rotator cuff healing in animal models, there is little information about the correct concentration and timing of the more than 1500 cytokines that interact during the healing process. There is only minimal evidence that platelet concentrates may lead to improvement in radiographic, but not clinical outcome. Using stem cells to biologically augment the reconstruction of the tears might have a great potential since these cells can differentiate into various cell types that are integral for healing. However, further studies are necessary to understand how to enhance the potential of these stem cells in a safe and efficient way. This article intends to give an overview of the biological augmentation options found in the literature.

Optimal Lateral Row Anchor Positioning in Posterior-Superior Transosseous Equivalent Rotator Cuff Repair: A Micro-Computed Tomography Study.

Background: The optimal placement of suture anchors in transosseous-equivalent (TOE) double-row rotator cuff repair remains controversial. Purpose: A 3-dimensional (3D) high-resolution micro–computed tomography (micro-CT) histomorphometric analysis of cadaveric proximal humeral greater tuberosities (GTs) was performed to guide optimal positioning of lateral row anchors in posterior-superior (infraspinatus and supraspinatus) TOE rotator cuff repair. Study Design: Descriptive laboratory study. Methods: Thirteen fresh-frozen human cadaveric proximal humeri underwent micro-CT analysis. The histomorphometric parameters analyzed in the standardized volumes of interest included cortical thickness, bone volume, and trabecular properties. Results: Analysis of the cortical thickness of the lateral rows demonstrated that the entire inferior-most lateral row, 15 to 21 mm from the summit of the GT, had the thickest cortical bone (mean, 0.79 mm; P = .0001), with the anterior-most part of the GT, 15 to 21 mm below its summit, having the greatest cortical thickness of 1.02 mm (P = .008). There was a significantly greater bone volume (BV; posterior, 74.5 ± 27.4 mm3; middle, 55.8 ± 24.9 mm3; anterior, 56.9 ± 20.7 mm3; P = .001) and BV as a percentage of total tissue volume (BV/TV; posterior, 7.3% ± 2.7%, middle, 5.5% ± 2.4%; anterior, 5.6% ± 2.0%; P = .001) in the posterior third of the GT than in intermediate or anterior thirds. In terms of both BV and BV/TV, the juxta-articular medial row had the greatest value (BV, 87.3 ± 25.1 mm3; BV/TV, 8.6% ± 2.5%; P = .0001 for both) followed by the inferior-most lateral row 15 to 21 mm from the summit of the GT (BV, 62.0 ± 22.7 mm3; BV/TV, 6.1% ± 2.2%; P = .0001 for both). The juxta-articular medial row had the greatest value for both trabecular number (0.3 ± 0.06 mm–1; P = .0001) and thickness (0.3 ± 0.08 μm; P = .0001) with the lowest degree of trabecular separation (1.3 ± 0.4 μm; P = .0001). The structure model index (SMI) has been shown to strongly correlate with bone strength, and this was greatest at the inferior-most lateral row 15 to 21 mm from the summit of the GT (2.9 ± 0.9; P = .0001). Conclusion: The inferior-most lateral row, 15 to 21 mm from the tip of the GT, has good bone stock, the greatest cortical thickness, and the best SMI for lateral row anchor placement. The anterior-most part of the GT 15 to 21 mm below its summit had the greatest cortical thickness of all zones. The posterior third of the GT also has good bone stock parameters, second only to the medial row. The best site for lateral row cortical anchor placement is 15 to 21 mm below the summit of the GT. Clinical Relevance: Optimal lateral anchor positioning is 15 to 21 mm below the summit of the greater tuberosity in TOE.

BiPOD Arthroscopic Acromioclavicular Repair Restores Bidirectional Stability

Stabilizing the acromioclavicular joint in the vertical and horizontal planes is challenging, and most current techniques do not reliably achieve this goal. The BiPOD repair is an arthroscopically assisted procedure performed with image intensifier guidance that reconstructs the coracoclavicular ligaments as well as the acromioclavicular ligaments to achieve bidirectional stability. Repair is achieved with a combination of 2-mm FiberTape (Arthrex, Naples, Florida) and 20-mm Poly-Tape (Neoligaments, Leeds, England) to achieve rigid repair, prevent bone abrasion, and promote tissue ingrowth. This study is a prospective review of the first 6 patients treated for high-grade acute acromioclavicular injury with the BiPOD technique. The study included 6 men who were 21 to 36 years old (mean, 27 years). At 6-month follow-up, complications were recorded and radiographic analysis was used to determine the coracoclavicular distance for vertical reduction and the amount of acromioclavicular translation on the Alexander axillary view was used to determine horizontal reduction. One patient had a superficial infection over the tape knot. The difference in coracoclavicular distance between the operated side and the uninvolved side was 9±2 mm preoperatively and 0.3±2 mm at 6-month follow-up. On Alexander axillary view, all 6 patients showed stable reduction, which is defined as a clavicle that is in line with the acromion. The findings show that BiPOD acromioclavicular reconstruction restores bidirectional stability of the acromioclavicular joint at 6 months. [Orthopedics. 2017; 40(1):e35-e43.].

Triceps-sparing extra-articular step-cut olecranon osteotomy for distal humeral fractures: an anatomic study.

BACKGROUND This anatomic study investigated the distal humeral articular surface exposure achievable through a triceps-sparing oblique extra-articular osteotomy of the olecranon with a step-cut modification compared with the anconeus flap transolecranon apex distal chevron osteotomy. In addition, the bone contact surface areas of the osteotomized surfaces after transolecranon and extra-articular osteotomies were compared. METHODS Seven pairs of fresh adult cadaveric elbow joints were examined. Each of the right elbows underwent triceps-sparing extra-articular step-cut olecranon osteotomy (SCOOT) with an anconeus flap, and the left elbows underwent the anconeus flap transolecranon apex distal chevron osteotomies (CO). The articular surface exposed by each of the osteotomy techniques was then digitally analyzed using a 3-dimensional measurement system. The bone contact surface area of the osteotomized surfaces was also assessed. RESULTS The percentage of total joint exposed by the SCOOT group was less than the CO group (SCOOT: 64% ± 3% vs. CO: 73% ± 3%; P = .002). There was significantly greater bone contact surface area of the osteotomized surfaces in the SCOOT group compared with the CO group (SCOOT: 1172 ± 251 mm2 vs. CO: 457 ± 133 mm2; P = .002). CONCLUSION The triceps SCOOT procedure with an anconeus flap provides excellent distal humeral articular surface exposure with the added benefit of a substantially increased (2.6-times) bone contact surface area of the osteotomized surfaces.

The Role of Capsular Repair in Latarjet Procedures: Commentary on an article by Yoshiaki Itoigawa, MD, PhD, et al.

The modified Latarjet-Patte procedure1 is thought to provide stability by both the “bone block” effect from the transfer of the coracoid process to the anteroinferior glenoid rim and the “sling effect” produced by the conjoined tendon and the lowered intact subscapularis below2,3. Another possible stabilizing procedure is the repair of the capsule to the transferred portion of the coracoacromial ligament (CAL) after coracoid fixation (capsular-CAL repair). It is unclear whether this has any harmful effects, such as restriction of range of motion. In their biomechanical cadaveric study, Yamamoto et al.3 demonstrated that at the end-range of arm position, capsular-CAL repair contributed 23% of the resistance to translational force, with the remaining 77% provided by the sling effect. At the mid-range of arm position, capsular-CAL repair had no effect on stability, with the sling effect contributing 51% to 62% of the resistance to translational force under increasing load and the remaining 38% to …

Many Shoulder MRI Findings in Elite Professional Throwing Athletes Resolve After Retirement: A Clinical and Radiographic Study

Background Anatomic findings on MRI scans of the shoulder likely affect patients differently based on their physical demands and fitness levels. The natural history of these anatomic findings once professional overhead athletes retire remains unclear. A better understanding of what happens with these findings after retirement may influence how we manage shoulder problems in athletes. Purpose (1) What is the natural history of MRI-observed findings in the throwing and nonthrowing shoulders of professional European handball players after retirement from the sport? What proportion of these individuals have diagnosable findings on MRI, and do these findings disappear after retirement? (2) Do clinical findings such as Constant and Murley score and shoulder ROM change after retirement in these professional overhead athletes? Methods The inception cohort of this series consisted of the entire Swiss National European handball team except the goalkeepers. These 30 professional players also played in the highest Swiss handball league in 2001. None of these players previously had shoulder surgery. During their career, they had a clinical assessment and bilateral shoulder MRI as part of an earlier study. We sought to evaluate the players who had retired and did not have a history of shoulder surgery, to evaluate the natural history of MRI-observed findings made in the initial study during their professional career. Of the 30 players, 10 were excluded (four continued to play professionally, four declined participation, and two had surgery after the initial study), leaving 20 (66%) for analysis at a mean of 6 years (SD, 3 years) after retirement. To gain a better understanding of the evolution of these MRI findings in the longer-term, we also evaluated 18 additional former professional European handball players who did not have any history of shoulder surgery, had all played in the highest Swiss league and for the National Team, and had terminated their career at a mean of 15 years (SD, 3 years) ago. All the subjects in both study groups (those at 6 and 15 years after retirement) underwent a detailed interview, standardized clinical examination including ROM measurements, collection of the Constant and Murley scores and the subjective shoulder value of both shoulders, and bilateral shoulder MRI. MRI findings (consisting of abnormalities and normal variations) were reported as radiographic diagnoses, independent of the potential that these findings could be considered normal variations in people in this age group. Results At the initial MRI evaluation, the proportion of active professional European handballers with diagnosable MRI findings in the throwing shoulder was 19 of 20 (95%) and for the handballers with nonthrowing shoulders was 17 of 20 (85%), while 15 years after retirement, both shoulders of all subjects showed MRI findings. None of the rotator cuff tears progressed to full-thickness tears after retirement. In the throwing shoulders, we observed fewer individuals with ganglion cysts larger than 5 mm (initial followup: six of 20 [30%] versus 6 years after retirement: 0 of 20 (0%); odds ratio, 14.5; [95% CI, 0.7-283]; p = 0.044). The Constant and Murley score increased in the throwing shoulder from 93 points (SD, 6 points) at initial followup to 98 points (SD, 3 points) at a mean of 6 years after retirement (mean difference, 5 points; SD, 5 points; 95% CI, 2.5-7.4; p < 0.001), and to 97 points (SD, 3 points) at a mean of 15 years after retirement. However these differences are below the typically reported minimum clinically important difference for the Constant and Murley score, and so are unlikely to be clinically relevant. External rotation in 90° abduction remained increased in the throwing shoulder compared with the nonthrowing shoulder up to 15 years after retirement (initial followup: mean difference, 8°; p = 0.014; 15 years after retirement: mean difference, 4°; SD, 15o; p = 0.026). Internal rotation remained decreased in the throwing compared with the nonthrowing shoulders (during the career: mean difference, 5° [SD, 10°], p = 0.036; 15 years after retirement: mean difference, 3° [SD, 4°], p = 0.021). Conclusions Our data suggest that findings of the throwing shoulder like partial rotator cuff tears, bony cysts and ganglions do not progress after retirement, and sometimes they resolve. Because of this and because many MRI changes correlate poorly with clinical symptoms, the indication for surgical treatment of these findings should be questioned very carefully. Level of Evidence Level II, prognostic study

The Role of Capsular Repair in Latarjet Procedures: Commentary on an article by Yoshiaki Itoigawa, MD, PhD, et al.: "Repairing the Capsule to the Transferred Coracoid Preserves External Rotation in the Modified Latarjet Procedure".

The modified Latarjet-Patte procedure1 is thought to provide stability by both the “bone block” effect from the transfer of the coracoid process to the anteroinferior glenoid rim and the “sling effect” produced by the conjoined tendon and the lowered intact subscapularis below2,3. Another possible stabilizing procedure is the repair of the capsule to the transferred portion of the coracoacromial ligament (CAL) after coracoid fixation (capsular-CAL repair). It is unclear whether this has any harmful effects, such as restriction of range of motion. In their biomechanical cadaveric study, Yamamoto et al.3 demonstrated that at the end-range of arm position, capsular-CAL repair contributed 23% of the resistance to translational force, with the remaining 77% provided by the sling effect. At the mid-range of arm position, capsular-CAL repair had no effect on stability, with the sling effect contributing 51% to 62% of the resistance to translational force under increasing load and the remaining 38% to …

The Role of Capsular Repair in Latarjet Procedures

The modified Latarjet-Patte procedure1 is thought to provide stability by both the “bone block” effect from the transfer of the coracoid process to the anteroinferior glenoid rim and the “sling effect” produced by the conjoined tendon and the lowered intact subscapularis below2,3. Another possible stabilizing procedure is the repair of the capsule to the transferred portion of the coracoacromial ligament (CAL) after coracoid fixation (capsular-CAL repair). It is unclear whether this has any harmful effects, such as restriction of range of motion. In their biomechanical cadaveric study, Yamamoto et al.3 demonstrated that at the end-range of arm position, capsular-CAL repair contributed 23% of the resistance to translational force, with the remaining 77% provided by the sling effect. At the mid-range of arm position, capsular-CAL repair had no effect on stability, with the sling effect contributing 51% to 62% of the resistance to translational force under increasing load and the remaining 38% to …