Sunil Rana

Catalyst-Free, One-Pot, Expeditious Synthesis of Aminoalkylnaphthols at Room Temperature

Abstract Aminoalkylnaphthols possess several biological and catalytic activities. A methodology has been developed for the multicomponent one-pot synthesis of aminoalkylnaphthols in dichloromethane under catalyst-free conditions at room temperature. The present approach possesses several advantages such as excellent yields, quick reaction time, mild reaction conditions, and very easy purification processes. Thirteen new compounds in addition to six known compounds have been synthesized by this methodology. GRAPHICAL ABSTRACT

FeCl3 catalysed multicomponent divergent synthesis of a library of indeno-fused heterocycles

A simple, straightforward and versatile multicomponent synthetic protocol for indeno-fused heterocycles, namely diindeno[1,2-b:2′,1′-e]pyridine, indeno[1,2-b]quinoline and indeno[1,2-b]cyclopenta[e]pyridine derivatives, has been developed. The strategy involves the one pot three component reaction of enaminone, dialkyl but-2-ynedioate and 1,3-indanedione catalysed by FeCl3 in acetonitrile under reflux. The presence of rotamers in the products with 2- and 3-substituted anilines as the amine component adds some interesting features to this expeditious domino reaction. In the course of the reaction, four new bonds (two C–C and two C–N bonds) and one stereocenter are formed in one operation. Mild reaction conditions, operational simplicity, wide substrate scope, product diversity and overall good yield make this reaction highly efficient for the library synthesis of indeno-fused heterocycles.

Polymer-supported triacetoxyborohydride: a novel reagent of choice for reductive amination

A novel polymer-supported triacetoxyborohydride reagent for reductive amination of aldehydes and ketones is reported. The bound reagent was found to be shelf-stable and provided broad scope and reactivity in reductive amination reactions under mild reaction conditions. Streamlined protocols for its application in reductive amination reactions using both primary and secondary amines are described.