Supriyatna

Antiplasmodial and other constituents from four Indonesian Garcinia spp.

Phytochemical investigations of four Garcinia spp. from Indonesia, i.e. Garcinia griffithii T. Anderson, Garcinia celebica L., Garcinia cornea L. and Garcinia cymosa K. Schum (Clusiaceae), have resulted in the isolation of a xanthone, 1,5-dihydroxy-3,6-dimethoxy-2,7-diprenylxanthone, 1,7-dihydroxyxanthone, isoxanthochymol, beta-sitosterol-3-O-beta-D-glucoside and stigmasterol-3-O-beta-D-glucoside from the stem bark of G. griffithii; friedelin and 3beta-hydroxy-23-oxo-9,16-lanostadien-26-oic acid or garcihombronane D from leaves of G. celebica; 23-hydroxy-3-oxo-cycloart-24-en-26-oic acid and epicatechin from stem bark of G. cornea; (+/-)-morelloflavone, morelloflavone-7-O-beta-D-glucoside or fukugiside, the triterpene 3beta-hydroxy-5-glutinen-28-oic acid and canophyllol from stem bark of G. cymosa. The xanthone and garcihombronane D displayed a selective activity against Plasmodium falciparum; isoxanthochymol and the triterpene beta-hydroxy-5-glutinen-28-oic acid a broad but non-selective antiprotozoal activity.

Anti-bacterial Activity of Prenylated Xanthone from The Bark of Garcinia lowa

Bioactivity-guided fractionation of a ethyl acetate extract of Garcinia lowa bark has led to the isolation and identification of a known prenylated xanthone, mangosharin, (2,6-dihydroxy-8-methoxy-5-(3-methylbut-2-enyl)xanthone (1, 15.4 mg) The structure of the compound was identified from analysis of their spectroscopic data and by comparison with previous studies.Compound 1 showed anti-bacterial activity against Sreptococcus mutans with MIC value of 7.25g/mL.

Tetraoksigenasi Santon dari Kulit Batang Garcinia nigrolineata Tetraoxygenated Xanthone from The Stem Bark of Garcinia nigrolineata

A tetraoxygenated xanthone, 1,7-dihidroxy-3-methoxy-4-(3methylbut-2-enyl),6’,6’ –dimethylpyrano (2’ , 3’ : 5, 6) xanthone had been isolated from the ethyl acetate extract of the stem bark of Garcinia nigrolineata Planch Ex T. Anders. The structure of these compounds were determined on the basis of spectroscopic NMR 1D and 2D.

Xanton dari Fraksi Aktif Antioksidan Kulit Batang Kandis Gajah (Garcinia griffithii T. Anders)

Garcinia is a large genus of polygamous trees or shrubs, distributed in the tropical Asia, Africa, and Polynesia, and is a rich source of bioactive molecules including xanthones, flavonoids, benzophenones, lactones, and phenolic acid. In the present study, an attempt was made to evaluate the antioxidant activity from stem bark of G. griffithii using radical scavenging 1,1-diphenyl-2-picryl hydrazyl (DPPH) model systems. Xanthone from antioxidant active fraction had been isolated and this compound had been identified by the use of ultraviolet (UV), infrared (IR), and proton nuclear magnetic resonance (1H-NMR) spectroscopy.