Susan Zollman
University of California, Los Angeles
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Featured researches published by Susan Zollman.
Genomics | 1987
Robert S. Sparkes; Susan Zollman; Ivana Klisak; Todd G. Kirchgessner; Michael Komaromy; T. Mohandas; Michael C. Schotz; Aldons J. Lusis
We have used cDNA probes for lipoprotein lipase and hepatic lipase to determine the chromosomal and subchromosomal locations of the human genes for these lipolytic enzymes. Southern blot analysis of genomic DNA from 17 independent mouse-human somatic cell hybrids demonstrated the presence of the gene for human lipoprotein lipase on chromosome 8, whereas the gene for hepatic lipase was on chromosome 15. Regional mapping of the genes by in situ hybridization to human chromosomes indicated that the lipoprotein lipase gene (LPL) resides in the p22 region of chromosome 8, while hepatic lipase gene (HL) resides in the q21 region of chromosome 15. We previously reported, on the basis of nucleotide and amino acid homologies, that these genes are members of a gene family of lipases, and, thus, the present findings indicate that the members of this family are dispersed. The results are also of significance with respect to disorders involving deficiencies of the enzymes. In particular, they suggest that certain rare combined deficiencies of both enzymes do not involve mutations of the structural loci.
Molecular and Cellular Biology | 1995
Wei Chen; Susan Zollman; Jean-Louis Couderc; Frank A. Laski
The gene bric à brac (bab) is required for the proper development of the limbs and ovary in Drosophila melanogaster. bab encodes a BTB domain (also called a POZ domain), an approximately 115-amino-acid conserved motif found primarily in the N termini of zinc finger proteins. In this paper, we show that the BTB domain of bab can mediate protein dimerization in vitro. In addition, we demonstrate that the first 51 amino acids of the bab BTB domain are sufficient for dimerization, and we identify amino acids within this region that are required for binding.
Genomics | 1987
Aldons J. Lusis; Susan Zollman; Robert S. Sparkes; Ivana Klisak; T. Mohandas; Dennis Drayna; Richard M. Lawn
We have used a cDNA probe for human cholesteryl ester transfer protein (CETP) to determine the chromosomal location for the human gene. Southern blot analysis of DNA from 17 independent mouse-human somatic cell hybrids demonstrated the presence of the gene for human CETP on chromosome 16. Regional mapping of the gene by in situ hybridization was consistent with these results and indicated that the gene resides in the 16q12-21 region of the chromosome. These findings provide an additional polymorphic marker for chromosome 16, as several relatively common restriction fragment length polymorphisms of the gene have previously been reported, and they have significance for studies directed at the identification of genetic factors affecting plasma lipoprotein metabolism and atherosclerosis.
Somatic Cell and Molecular Genetics | 1986
Margarete Mehrabian; Robert S. Sparkes; T. Mohandas; Ivana Klisak; Verne N. Schumaker; Camilla Heinzmann; Susan Zollman; Yuanhong Ma; Aldons J. Lusis
Apolipoprotein B (apoB) is the major protein component of low-density and very-low-density lipoproteins. We have recently isolated nonoverlapping cDNA clones for apoB and confirmed their identity by sequence comparisons. We now report the mapping of the human apoB gene (APOB)to the p23–p24 region of chromosome 2 by examination of human-mouse somatic cell hybrids and by in situ hybridization to human chromosomes. Thus, APOBis unlinked to members of the dispersed gene family encoding other apolipoprotein species or to the gene encoding the low-density lipoprotein receptor. Hybridization analysis with genomic DNA and liver and intestinal mRNA suggests that APOBencodes both the high-molecular-weight form of apoB (apoB100) incorporated into very-low-density lipoproteins in liver and the lower-molecular-weight form (apoB48) incorporated into chylomicrons in intestine. Restriction fragment length polymorphisms of APOBhave been identified and should prove useful in examining the possibility that genetic variations of APOBare involved in dyslipoproteinemias and atherosclerosis.
Human Genetics | 1986
R. S. Sparkes; T. Mohandas; Camilla Heinzmann; Michael B. Gorin; Susan Zollman; Joseph Horwitz
SummaryThe gene map assignment of a human beta-crystallin gene to 17cen-q23 has been made using a bovine probe in the study of human-mouse and human-Chinese hamster somatic cell hybrids containing parts of human chromosome 17.
DNA and Cell Biology | 1988
Shiuan Chen; Marc J. Besman; Robert S. Sparkes; Susan Zollman; Ivana Klisak; T. Mohandas; Peter F. Hall; John E. Shively
Development | 2002
Jean-Louis Couderc; Dorothea Godt; Susan Zollman; Jiong Chen; Michelle Li; Stanley Tiong; Sarah E. Cramton; Isabelle Sahut-Barnola; Frank A. Laski
Journal of Lipid Research | 1992
Joyce J. Hwa; Susan Zollman; Craig H. Warden; Benjamin A. Taylor; Peter A. Edwards; Alan M. Fogelman; Aldons J. Lusis
Molecular and Cellular Biology | 1991
A C Chain; Susan Zollman; J C Tseng; Frank A. Laski
Current Eye Research | 1987
David Hogg; Michael B. Gorin; Camilla Heinzmann; Susan Zollman; T. Mohandas; Ivana Klisak; Robert S. Sparkes; Martin L. Breitman; Lap-Chee Tsui; Joseph Horwitz