Sylvia Lee-Huang
Government of the United States of America
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Featured researches published by Sylvia Lee-Huang.
The Open Conference Proceedings Journal | 2010
Paul L. Huang; Philip Lin Huang; Sylvia Lee-Huang
Diabetes, obesity, and the metabolic syndrome all increase the risk for cardiovascular disease. Epidemiologic studies have demonstrated that a Mediterranean diet rich in olive oil is associated with decrease in risk for cardiovascular disease, obesity, and diabetes. Although some of the protection may be from the unsaturated fatty acid components of such a diet, additional small molecules found in olive oil and olive plants may confer protection, including the polyphenol oleuropein and hydroxytyrosol. We report here studies in mice that document the bioavailability of these molecules when administered orally. Using the apoE knockout mouse model fed a high fat diet, we assessed the effects of orally administered oleuropein on diet-induced atherosclerosis. Oleuropein significantly reduced the extent of atherosclerosis found in the aorta of apoE knockout mice. Molecular modeling studies indicate that oleuropein binds to the peroxisome proliferator activating receptors (PPAR) ufffb , ufffb , and ufffb , but it does so with distinct conformations that differ from the way that PPAR ufffb -, ufffb -, and ufffb -specific agonists bind to their active sites. The manner with which oleuropein binds uniquely to the various PPARs offers a possible explanation for its effects on metabolism and cardiovascular disease.
Proceedings of the National Academy of Sciences of the United States of America | 1999
Sylvia Lee-Huang; Paul L. Huang; Sun Y; Hsiang-Fu Kung; Blithe Dl; Huaibin Chen
Proceedings of the National Academy of Sciences of the United States of America | 1995
Sylvia Lee-Huang; Paul L. Huang; Aldar S. Bourinbaiar; Huaibin Chen; Hsiang-Fu Kung
Proceedings of the National Academy of Sciences of the United States of America | 1994
Sylvia Lee-Huang; Hsiang-Fu Kung; Paul L. Huang; Aldar S. Bourinbaiar; J L Morell; J H Brown; Wen-Po Tsai; A Y Chen; Henry I. Huang
Archive | 1991
Sylvia Lee-Huang; Hsiang-Fu Kung; Paul L. Huang; Philip Lin Huang; Peter Huang; Henry I. Huang; Hao-Chia Chen
Archive | 1991
Sylvia Lee-Huang; Philip Lin Huang; Peter L. Nara; Hao-Chia Chen; Hsiang-Fu Kung; Peter Huang; Henry I. Huang; Paul L. Huang
International Journal of Oncology | 1994
Sm Rybak; Jj Lin; Dl Newton; Hf Kung; A Monks; Hc Chen; Pl Huang; Sylvia Lee-Huang
Archive | 1992
Sylvia Lee-Huang; Philip Lin Huang; Hao-Chia Chen; Hsiang-Fu Kung; Peter Huang; Henry I. Huang; Paul L. Huang
The Open Conference Proceedings Journal | 2010
Paul L. Huang; Philip Lin Huang; Sylvia Lee-Huang
Archive | 2016
Sylvia Lee-Huang; Paul P. Huang; Philip Lin Huang