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Featured researches published by T E Bross.


Trends in Biochemical Sciences | 1985

Phosphoinositide turnover provides a link in stimulus—response coupling

Philip W. Majerus; David B. Wilson; Thomas M. Connolly; T E Bross; Ellis J. Neufeld

Abstract Much excitement has resulted from the discovery that phosphatidylinositol and its phosphorylated derivatives are storage forms of messenger molecules that can be released in response to specific extracellular signals. Signal molecules bind to cell surface receptors and the messenger molecules derived from the phosphoinositides couple the signal to a variety of responses within and between cells.


Biochemical and Biophysical Research Communications | 1983

RHC 80267 does not inhibit the diglyceride lipase pathway in intact platelets

T E Bross; Stephen M. Prescott; Philip W. Majerus

RHC 80267 inhibits diglyceride lipase activity in microsomes from canine platelets (1). Chau and Tai (2) reported that RHC 80267 prevents the transient accumulation of monoglyceride in thrombin-stimulated human platelets, while leaving arachidonate release unimpaired. In contrast, we find that while the drug inhibits both diglyceride lipase (I50 = 15 microM) and monoglyceride lipase (I50 = 11 microM) activities in platelet microsomes, it is ineffective when added to intact platelets. The transient intermediates in the diglyceride lipase pathway, 1,2-diglyceride and 2-monoglyceride, both accumulated after thrombin stimulation of intact platelets treated with RHC 80267, and arachidonate release was not inhibited. We conclude that RHC 80267 cannot be used to evaluate the diglyceride lipase pathway in intact platelets.


Science | 1986

The metabolism of phosphoinositide-derived messenger molecules

Philip W. Majerus; Thomas M. Connolly; Hans Deckmyn; Theodora S. Ross; T E Bross; Hidemi Ishii; Vinay S. Bansal; David B. Wilson


Journal of Biological Chemistry | 1984

Hydrolysis of polyphosphoinositides by purified sheep seminal vesicle phospholipase C enzymes.

David B. Wilson; T E Bross; Sandra L. Hofmann; Philip W. Majerus


Journal of Biological Chemistry | 1985

Isolation of a phosphomonoesterase from human platelets that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate.

Thomas M. Connolly; T E Bross; Philip W. Majerus


Journal of Biological Chemistry | 1987

The metabolism of tris- and tetraphosphates of inositol by 5-phosphomonoesterase and 3-kinase enzymes.

Thomas M. Connolly; Vinay S. Bansal; T E Bross; R F Irvine; Philip W. Majerus


Journal of Biological Chemistry | 1986

Isolation and characterization of the inositol cyclic phosphate products of phosphoinositide cleavage by phospholipase C. Metabolism in cell-free extracts.

Thomas M. Connolly; David B. Wilson; T E Bross; Philip W. Majerus


Proceedings of the National Academy of Sciences of the United States of America | 1985

Inositol cyclic phosphates are produced by cleavage of phosphatidylphosphoinositols (polyphosphoinositides) with purified sheep seminal vesicle phospholipase C enzymes

David B. Wilson; T E Bross; W R Sherman; R A Berger; Philip W. Majerus


Proceedings of the National Academy of Sciences of the United States of America | 1986

Inositol cyclic triphosphate [inositol 1,2-(cyclic)-4,5-triphosphate] is formed upon thrombin stimulation of human platelets

H Ishii; T M Connolly; T E Bross; Philip W. Majerus


Journal of Biological Chemistry | 1984

A mutant HSDM1C1 fibrosarcoma line selected for defective eicosanoid precursor uptake lacks arachidonate-specific acyl-CoA synthetase.

E J Neufeld; T E Bross; Philip W. Majerus

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Philip W. Majerus

Washington University in St. Louis

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David B. Wilson

Washington University in St. Louis

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Thomas M. Connolly

Washington University in St. Louis

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Daniel L. Lips

Washington University in St. Louis

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Theodora S. Ross

University of Texas Southwestern Medical Center

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Vinay S. Bansal

Washington University in St. Louis

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Hans Deckmyn

Katholieke Universiteit Leuven

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Ellis J. Neufeld

Washington University in St. Louis

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H Ishii

Washington University in St. Louis

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Hidemi Ishii

Washington University in St. Louis

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