T Hofbauer
Medical University of Vienna
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by T Hofbauer.
Circulation Research | 2015
Andreas Mangold; Sherin Alias; T Scherz; T Hofbauer; Johannes Jakowitsch; Adelheid Panzenböck; Daniel Simon; Daniela Laimer; Christine Bangert; Andreas A. Kammerlander; Julia Mascherbauer; Max-Paul Winter; Klaus Distelmaier; Christopher Adlbrecht; Klaus T. Preissner; Irene M. Lang
RATIONALE Mechanisms of coronary occlusion in ST-elevation acute coronary syndrome are poorly understood. We have previously reported that neutrophil (polymorphonuclear cells [PMNs]) accumulation in culprit lesion site (CLS) thrombus is a predictor of cardiovascular outcomes. OBJECTIVE The goal of this study was to characterize PMN activation at the CLS. We examined the relationships between CLS neutrophil extracellular traps (NETs), bacterial components as triggers of NETosis, activity of endogenous deoxyribonuclease, ST-segment resolution, and infarct size. METHODS AND RESULTS We analyzed coronary thrombectomies from 111 patients with ST-elevation acute coronary syndrome undergoing primary percutaneous coronary intervention. Thrombi were characterized by immunostaining, flow cytometry, bacterial profiling, and immunometric and enzymatic assays. Compared with femoral PMNs, CLS PMNs were highly activated and formed aggregates with platelets. Nucleosomes, double-stranded DNA, neutrophil elastase, myeloperoxidase, and myeloid-related protein 8/14 were increased in CLS plasma, and NETs contributed to the scaffolds of particulate coronary thrombi. Copy numbers of Streptococcus species correlated positively with dsDNA. Thrombus NET burden correlated positively with infarct size and negatively with ST-segment resolution, whereas CLS deoxyribonuclease activity correlated negatively with infarct size and positively with ST-segment resolution. Recombinant deoxyribonuclease accelerated the lysis of coronary thrombi ex vivo. CONCLUSIONS PMNs are highly activated in ST-elevation acute coronary syndrome and undergo NETosis at the CLS. Coronary NET burden and deoxyribonuclease activity are predictors of ST-segment resolution and myocardial infarct size.
European Heart Journal | 2018
T Hofbauer; T Scherz; A Ondracek; J Mueller; Adelheid Panzenboeck; C Feist; L Kascha; A Frueh; I Horvat Menih; S Kuehn; Andreas Mangold; Irene Lang
Cardiovascular Research | 2018
T Scherz; T Hofbauer; A Ondracek; Daniel Simon; Christoph Testori; Fritz Sterz; Andreas Mangold; Irene Lang
Cardiovascular Research | 2018
A Ondracek; T Hofbauer; T Scherz; J Mueller; Adelheid Panzenboeck; Andreas Mangold; Irene Lang
Cardiovascular Research | 2018
Andreas Mangold; T Scherz; T Hofbauer; A Ondracek; Daniel Simon; Christoph Testori; Fritz Sterz; Irene Lang
Cardiovascular Research | 2018
L Kascha; T Hofbauer; Max-Paul Winter; Adelheid Panzenboeck; Klaus Distelmaier; T Scherz; A Ondracek; C Feist; Andreas Mangold; Irene Lang
Cardiovascular Research | 2018
T Hofbauer; T Scherz; A Ondracek; J Mueller; Andreas Mangold; Irene Lang
Atherosclerosis | 2017
T Hofbauer; T Scherz; Julian Müller; Houtan Heidari; Nikolai Staier; Adelheid Panzenböck; Andreas Mangold; Irene M. Lang
Cardiovascular Research | 2014
Andreas Mangold; T Scherz; Sherin Alias; T Hofbauer; Johannes Jakowitsch; Christine Bangert; S Pfaffenberger; Max-Paul Winter; Klaus T. Preissner; Irene Lang
Cardiovascular Research | 2014
T Scherz; Andreas Mangold; T Hofbauer; Christopher Adlbrecht; Irene Lang