T Scherz
Medical University of Vienna
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Publication
Featured researches published by T Scherz.
Circulation Research | 2015
Andreas Mangold; Sherin Alias; T Scherz; T Hofbauer; Johannes Jakowitsch; Adelheid Panzenböck; Daniel Simon; Daniela Laimer; Christine Bangert; Andreas A. Kammerlander; Julia Mascherbauer; Max-Paul Winter; Klaus Distelmaier; Christopher Adlbrecht; Klaus T. Preissner; Irene M. Lang
RATIONALE Mechanisms of coronary occlusion in ST-elevation acute coronary syndrome are poorly understood. We have previously reported that neutrophil (polymorphonuclear cells [PMNs]) accumulation in culprit lesion site (CLS) thrombus is a predictor of cardiovascular outcomes. OBJECTIVE The goal of this study was to characterize PMN activation at the CLS. We examined the relationships between CLS neutrophil extracellular traps (NETs), bacterial components as triggers of NETosis, activity of endogenous deoxyribonuclease, ST-segment resolution, and infarct size. METHODS AND RESULTS We analyzed coronary thrombectomies from 111 patients with ST-elevation acute coronary syndrome undergoing primary percutaneous coronary intervention. Thrombi were characterized by immunostaining, flow cytometry, bacterial profiling, and immunometric and enzymatic assays. Compared with femoral PMNs, CLS PMNs were highly activated and formed aggregates with platelets. Nucleosomes, double-stranded DNA, neutrophil elastase, myeloperoxidase, and myeloid-related protein 8/14 were increased in CLS plasma, and NETs contributed to the scaffolds of particulate coronary thrombi. Copy numbers of Streptococcus species correlated positively with dsDNA. Thrombus NET burden correlated positively with infarct size and negatively with ST-segment resolution, whereas CLS deoxyribonuclease activity correlated negatively with infarct size and positively with ST-segment resolution. Recombinant deoxyribonuclease accelerated the lysis of coronary thrombi ex vivo. CONCLUSIONS PMNs are highly activated in ST-elevation acute coronary syndrome and undergo NETosis at the CLS. Coronary NET burden and deoxyribonuclease activity are predictors of ST-segment resolution and myocardial infarct size.
Heart | 2018
Christoph Testori; Dietrich Beitzke; Andreas Mangold; Fritz Sterz; Christian Loewe; Christoph Weiser; T Scherz; Harald Herkner; Irene Lang
Objective To evaluate the effect of prereperfusion hypothermia initiated in the out-of-hospital setting in awake patients with ST-segment elevation myocardial infarction (STEMI) on myocardial salvage measured by cardiac MRI (CMR). Methods Hypothermia was initiated within 6 hours of symptom onset by the emergency medical service with surface cooling pads and cold saline, and continued in the cath lab with endovascular cooling (target temperature: ≤35°C at time of reperfusion). Myocardial salvage index (using CMR) was compared in a randomised, controlled, open-label, endpoint blinded trial to a not-cooled group of patients at day 4±2 after the event. Results After postrandomisation exclusion of 19 patients a total of 101 patients were included in the intention-to-treat analysis (control group: n=54; hypothermia group: n=47). Target temperature was reached in 38/47 patients (81%) in the intervention group. Study-related interventions resulted in a delay in time from first medical contact to reperfusion of 14 min (control group 89±24 min; hypothermia group 103±21 min; p<0.01). Myocardial salvage index was 0.37 (±0.26) in the control group and 0.43 (±0.27) in the hypothermia group (p=0.27). No differences in cardiac biomarkers or clinical outcomes were found. In a CMR follow-up 6 months after the initial event no significant differences were detected. Conclusion Out-of-hospital induced therapeutic hypothermia as an adjunct to primary percutaneous coronary intervention did not improve myocardial salvage in patients with STEMI. Trial registration number NCT01777750
European Heart Journal | 2018
T Hofbauer; T Scherz; A Ondracek; J Mueller; Adelheid Panzenboeck; C Feist; L Kascha; A Frueh; I Horvat Menih; S Kuehn; Andreas Mangold; Irene Lang
Cardiovascular Research | 2018
T Scherz; T Hofbauer; A Ondracek; Daniel Simon; Christoph Testori; Fritz Sterz; Andreas Mangold; Irene Lang
Cardiovascular Research | 2018
A Ondracek; T Hofbauer; T Scherz; J Mueller; Adelheid Panzenboeck; Andreas Mangold; Irene Lang
Cardiovascular Research | 2018
Andreas Mangold; T Scherz; T Hofbauer; A Ondracek; Daniel Simon; Christoph Testori; Fritz Sterz; Irene Lang
Cardiovascular Research | 2018
L Kascha; T Hofbauer; Max-Paul Winter; Adelheid Panzenboeck; Klaus Distelmaier; T Scherz; A Ondracek; C Feist; Andreas Mangold; Irene Lang
Cardiovascular Research | 2018
T Hofbauer; T Scherz; A Ondracek; J Mueller; Andreas Mangold; Irene Lang
Atherosclerosis | 2017
T Hofbauer; T Scherz; Julian Müller; Houtan Heidari; Nikolai Staier; Adelheid Panzenböck; Andreas Mangold; Irene M. Lang
Cardiovascular Research | 2014
Andreas Mangold; T Scherz; Sherin Alias; T Hofbauer; Johannes Jakowitsch; Christine Bangert; S Pfaffenberger; Max-Paul Winter; Klaus T. Preissner; Irene Lang