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Dive into the research topics where Tadashi Shirasaka is active.

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Featured researches published by Tadashi Shirasaka.


Synthetic Communications | 1990

First Synthesis of Cotarnone, the Key Intermediate for the Synthesis of Cotarnine

Tadashi Shirasaka; Yuki Takuma; Naoshi Imaki

Abstract The first synthesis of cotarnone (2), a degradation product of cotarnine (1), was achieved from 2-hydroxy-3-methoxy-benzaldehyde (o-vanillin), and 2 can be converted to 1 by a known method.


Synthetic Communications | 1990

Preparation of 2-Methoxy-3,4-methylenedioxybenzaldehyde (Croweacin Aldehyde) from Pyrogallol

Tadashi Shirasaka; Yuki Takuma; Naoshi Imaki

Abstract 2-Methoxy-3,4-methylenedioxybenzaldehyde (croweacin aldehyde) of high purity was prepared in 55% overall yield from pyrogallol.


Journal of Organic Chemistry | 1990

Practical synthesis of 5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-ol (cotarnine)

Tadashi Shirasaka; Yuki Takuma; Tetsuro Shimpuku; Naoshi Imaki


Chemical & Pharmaceutical Bulletin | 1994

Syntheses and Pharmacological Activities of Novel Optically Active Inhibitors of Acyl-CoA : Cholesterol O-Acyltransferase : EAB-309 ((R)-N-2-(1, 3-Benzodioxol-4-yl)heptyl-N'-2, 6-diisopropylphenylurea) and Its Enantiomer

Tetsuo Sekiya; Shinya Inoue; Tadashi Shirasaka; Chiaki Miyajima; Hiromi Okushima; Kazuo Suzuki; Mizue Kawai; Masayuki Mitsuka; Kouhei Umezu


Archive | 1993

Carboxamide and urea derivatives having ACAT-inhibiting activityM

Tetsuo Jikihara; Tadashi Shirasaka; Kazuo Suzuki; Hiroko Suzuki; Masao Taniguchi; Shinya Inoue


Synthesis | 1991

Efficient Synthesis of (E)-9-Chloro-4-methyl-8-oxo-4-nonenoic Acid from 4-Chloro-2-methyl-2-butene

Hisao Takayanagi; Tadashi Shirasaka; Yoshiharu Morita


Archive | 1986

Process for preparing cotarnine

Yoshiharu Morita; Naoshi Imaki; Tadashi Shirasaka; Tetsuro Shimpuku


Archive | 1986

4-hydroxy-8-methoxy-2-methyl-6, 7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline, and process for preparing the same

Yoshiharu Morita; Naoshi Imaki; Hisao Takayanagi; Tadashi Shirasaka; Tetsuro Shimpuku; Yuki Takuma; Mari Oishi


Archive | 1993

Dérivés d'amide carboxylique et d'usées ayant une activité inhibitive d'ACAT

Tetsuo Jikihara; Tadashi Shirasaka; Kazuo Suzuki; Hiroko Suzuki; Masao Taniguchi; Shinya Inoue


Archive | 1988

Certain 6,7-methylene dioxydihydro or tetrahydro-isoquinoline derivatives

Yoshiharu Morita; Naoshi Imaki; Hisao Takayanagi; Tadashi Shirasaka; Tetsuro Shimpuku; Yuki Takuma; Mari Oishi

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Yuki Takuma

Mitsubishi Chemical Corporation

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