Tae-Youl Kim

Transdermal delivery system of triamcinolone acetonide from a gel using phonophoresis

Triamcinolone acetonide (TA) is a corticosteroid that is used in the systemic and topical treatment of many inflammatory diseases. In this study, a phonophoretic drug delivery system was designed to enhanced the TA permeability and the influence of ultrasound was examined. In order to establish the transdermal delivery system for TA, a hydrophilic carbopol gel containing TA was prepared after adopting phonophoresis. A permeation study treatment was carried out for 10 h. The level of TA permation through the skin was evaluated under various ultrasound conditions including the frequency (1.0, 3.0 MHz), intensity (1.0, 2.5 W/cm2), and duty cycle (continuous, pulse mode) using a 0.5% TA gel. The highest permeation was observed under the ultrasound treatment conditions of low frequency, high intensity, and in continuous mode.

Anti-hyperalgesic and anti-inflammatory effects of Ketorolac Tromethamine gel using pulsed ultrasound in inflamed rats

The aim of this study was to determine if a Ketorolac Tromethamine (KT) gel solution could be administered in vivo via phonophoretic transdermal delivery using pulsed ultrasound by examining its anti-hyperalgesic and anti-inflammatory effects in a rat carrageenen inflammation model. 1% carrageenan was injected into the plantar surface of the right hindpaw of a rat, and anti-hyperalgesic and anti-inflammatory effects of KT via phonophoretic transdermal delivery were examined. The changes in the mechanical and thermal hyperalgesia, nociceptive flexor reflex (NFR), as well as the swelling changes were determined. According to the anti-hyperagesia and anti-inflammation tests, which were used to determine the change in the pain thresh-old, NFR and swelling showed that the group given the phonophoretic transdermal delivery of KT exhibited significantly more noticeable anti-hyperalgesic and anti-inflammatory effects than those treated with the simple application of a KT gel. The transdermal application of KT gel using phonophoresis had significant anti-hyperalgesic and anti-inflammatory effects. These findings suggest that the transdermal administration of a KT gel using phonophoresis using pulsed ultrasound might be useful for treating acute inflammation and pain.

The effects of ketorolac tromethamine and baicalein on the levels of inflammatory factors in human synoviocytes

This study examined the effects of ketorolac tromethamine (KT) and baicalein (BE) on the levels of inflammatory factors in human synoviocytes. The fibroblast-like synoviocytes (FLS) cells were used to determine the possible regulatory effects of KT and BE (KTBE) on the levels of inflammatory factors in FLS cells. In addition, the levels of TNF-α, IL-6, and IL-1β mRNA expression in FLS cells induced by a TNF-α and IL-1β co-treatment were largely inhibited by a KTBE treatment. The level of FLS cells proliferation was increased by IL-1β and TNF-α, and strongly inhibited by KTBE treatment. The production of oxygen species (ROS) was inhibited by KTBE in FLS cells. KTBE appears to regulate the levels of mRNA that are important for regulating RA progression.

The Effect of Balance Control and Vestibular Function by an Aquatic Rotation Control and the Obstacle Avoidance Underwater with Hemiplegia Patients

Purpose : The objective of this study is to effect of an aquatic rotation control and obstacle avoidance when conducted underwater on hemiplegia patient`s balance ability and vestibular function. Methods : Twelve hemiplegia patients participated and were randomly assigned to a control group(I) with standard physical therapy and an aquatic group(II) with an aquatic rotation control, obstacle avoidance and standard physical therapy as well. The aquatic group trained using a Halliwick rotation control and obstacle avoidance through 3 times per week over 6 weeks. For all subjects, vestibular function, their balance, the change of electrooculogram (EOG), the change of accelerometer axis and torsiometer according to visual sense, vestibular sense with galvanic vestibular stimulation (GVS) or not during leg close stance were measured. Results : The EOG in the vertical and horizontal (p

Ultrasound Imaging and Electrophysiological Characteristic According to Activity Levels of Myofascial Trigger Point

Purpose : This study is to offer clinical primary data that examines the change of imaging structure and the quantitative evaluation of muscle activity on myofascial trigger points. This study examines neuromuscular physiological characteristic by comparing the differences in physical findings, pressure pain threshold, imaging, and electrophysiological characteristics in latent and active myofascial trigger points muscle and normal muscle through the following experimental procedures. Methods : The participants for the study were thirty-three adults in their twenties. We divided three groups into normal, latent and active myofascial trigger points groups by physical findings. We analyzed the results of measured pressure pain, threshold for pain, ultrasound imaging perform for structure characteristic of muscle, surface EMG according to type of muscle contraction for function of muscle contraction. Results : Significant differences were indicated in pressure pain threshold (p

Analysis of Ultrasonography on Biceps Brachii Muscle of Hemiplegic Patient

Purpose : This study aims to comparison of ultrasonography on both sides of biceps brachii muscle of hemiplegic patient. Methods : The biceps brachii muscle of fifteen subjects (5 male, 10 female) with stroke were scanned with ultrasonography at the muscle belly at rest at elbow angles of 90 deg. The echogenicity (density, white area index; WAI, anatomic cross-sectional area; ACSA, volume) of ultrasonography was examined. Results : In the biceps brachii muscle, there were significant differences of density, WAI, ACSA, and volume between affected side and non-affected side. biceps brachii muscle, echogenicity (density, WAI) of the affected side was higher than non-affected side. biceps brachii muscle, echogenicity (ACSA, volume) of the non-affected side was higher than affected side. Conclusion : This study showed that change of skeletal muscle architecture properties occurred biceps brachii muscle of the affected side muscle of hemiplegic patient.

The Effect of Proprioceptive Neuromuscular Facilitation and Traditional Trunk Stabilization Training on the Rectus Abdominis Muscle Contraction

Purpose : The purpose of this study was to study the effect of rectus abdominal muscle contraction by proprioceptive neuromuscular facilitation trunk stabilization training using extremity simultaneous pattern (PNF trunk stabilization training) and traditional trunk stabilization training methods. Methods : A group of 24 adults male and female, healthy, with no previous medical history nor disability in neuromuscular system and musculoskeletal system was chosen as subjects, and was divided into a control group, a PNF trunk stabilization training group and a traditional trunk stabilization training group. Experiments were performed on the last two groups, 3 times a week for 6 weeks, totaling 18 times. Using a dynamometer, muscle strength and endurance time on trunk flexion were measured before and after each experiment, and surface electromyography in left and right rectus abdominis were measured. Results : following results were obtained; 1. As for the change in the maximal voluntary isometric contraction (MVIC), all subjects in the trunk stabilization training group showed significant difference from those in the control group. 2. As for surface electromyography measurement and the changes in root mean square at the time of trunk flexion, in the left rectus abdominis, PNF trunk stabilization training group showed significant difference from the control group, while in the right rectus abdominis, traditional trunk stabilization training group showed significant difference. Conclusion : To sum up the results, both trunk stabilization training groups showed improvement in the MVIC of abdominal muscle, motor unit action potential activity, but the difference between two trunk stabilization training groups was not significant. Therefore, while trunk stabilization training significantly improved abdominal muscle contraction, but the difference attributable to training methods was found to be insignificant.

Transdermal Delivery and Analgesic Effects of Lidocaine Hydrogel by Phonophoresis

To investigate the permeability of lidocaine, percutaneous absorption studies were performed using excised hairless mouse skin and the penetration of lidocaine via the skin was determined. To increase the skin permeation of lidocine, the effects of , , and were investigated. The skin permeation of lidocaine was increased when and were used as permeation enhancer. To evaluate the influence of ultrasound, various factors such as application modes (continuous mode and pulsed mode), frequency (1.0 and 3.0 MHz) and intensity (1.0, 1.5 and 2.0 w/) were investigated with lidocaine hydrogel. The pronounced effect of ultrasound on the skin permeation of lidocaine was observed at all ultrasound energy levels. The influence of frequency having an effect on skin permeation rate was higher in the case of using 1 MHz, 2.0 w/ and continuous treatment. As the intensity of ultrasound increased, the permeation of lidocaine was accelerated. The in vivo anesthetic effects were evaluated by two aspects as mechanical threshold and electrical threshold. Six healthy volunteers consented to the randomized, double-blind, and cross-over designed study in each group. In each subject, 3 groups were adapted such as K group (ultrasound with gel base only), L group (lidocaine gel) and B group (ultrasound with lidocaine gel). In conclusion, lidocaine was potent anesthetic which could be block pain threshold effectively. And ultrasound could accelerate the skin penetration of lidocaine. The phonophoretic delivery system could be a good candidate for lidocaine as a local anaesthetic to improve the skin permeation and in vivo anaesthetic effect.