Tai Li

Association between sildenafil and inflammation markers/mediators.

Article history: Received 28 June 2015 Accepted 30 June 2015 Available online 3 July 2015 cytokines are influenced by heart dysfunction. Both HF and ED are associated with increased levels of proinflammatory cytokines, such as TNF-α, IL-6 and IL-8 [2]. Recently, one study recruited 40 well-trained endurance athletes that underwent evaluation prior to and immediately following one of four endurance sporting events ranging from 3 to 11 hour duration. Cytokines (IL-1β, IL-6,

High mobility group box 1 protein attenuates myocardial ischemia reperfusion injury via inhibition of the p38 mitogen‑activated protein kinase signaling pathway

The present study aimed to determine the effects of high mobility group box 1 protein (HMGB1) on myocardial ischemia reperfusion (I/R) injury in rats following acute myocardial ischemia and investigate the underlying molecular mechanisms of these effects. Male Wistar rats were randomly divided into the following groups (n=10/group): Sham operation; I/R; HMGB50 (50 ng/kg HMGB1 before I/R); HMGB100 (100 ng/kg HMGB1 before I/R); and HMGB200 (200 ng/kg HMGB1 before I/R). Serum cardiac troponin I (cTnI), interleukin (IL)-6 and tumor necrosis factor (TNF)-α levels were subsequently measured. Myocardial levels of malondialdehyde (MDA) and superoxide dismutase (SOD) were also determined. Myocardial infarction size (IS) was determined by 2,3,5-triphenyltetrazolium chloride staining. Myocardial expression of hypoxia inducible factor (HIF)-1α and phosphorylated p38 mitogen-activated protein kinase (P-p38 MAPK) protein was measured using western blotting. The results demonstrated that HMGB1 significantly decreased serum levels of cTnI, IL-6 and TNF-α and myocardial IS in I/R rats compared with the sham group (all P<0.05). HMGB1 also significantly decreased and increased myocardial levels of MDA and SOD, respectively (both P<0.05). HMGB1 significantly increased myocardial expression of HIF-1α and decreased expression of P-p38 MAPK following I/R (both P<0.05). These effects of HMGB1 occurred in a dose-dependent manner. The results of the current study indicate that the cardioprotective effects of intravenous HMGB1 are associated with increased myocardial expression of HIF-1α via inhibition of P-p38 MAPK expression, leading to inhibition of the P-p38 MAPK signaling pathway.

Serum albumin levels might be an adverse predictor of long term mortality in patients with acute myocardial infarction

Article history: Received 2 August 2016 Received in revised form 11 August 2016 Accepted 12 August 2016 Available online 21 August 2016 levelwas an independent predictor of no-reflowafter primary PCI in patients with acutemyocardial infarction. In their study, they had enrolled 536 patients (aged 60 ± 13 years, 74% men) who underwent PCI. The results suggested that admission serum albumin were significantly lower in the no-reflow group than in the =normal reflow group (3.55 ± 0.44 vs. 4.01 ± 0.32 mg/dL, p b 0.001). Also, in multivariate analysis, lower serumalbumin level remained an independent predictor

Autophagy in myocardial ischemia reperfusion injury: Friend or foe?

Article history: Received 9 January 2017 Accepted 12 January 2017 jury. Overexpressed iNOS in I/R myocardium could improve migration and apoptosis of human umbilical vein endothelial cells and it was associated with increased autophagy [5]. Nonetheless, a-kinase anchoring protein 1 deficiency, degradation of gap junction protein connexin43, and PI3K/SGK1/GSK3β signaling pathway were also participate in the

Atherosclerosis is critical in the pathogenesis of erectile dysfunction

a Department of Cardiology, Liaocheng Peoples Hospital and Clinical School of Taishan Medical University, Shandong Province, Liaocheng 252000, PR China b Department of Echocardiography, Liaocheng Peoples Hospital and Clinical School of Taishan Medical University, Shandong Province, Liaocheng 252000, PR China c Department of Andrology, Liaocheng Peoples Hospital and Clinical School of Taishan Medical University, Liaocheng 252000, PR China