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Dive into the research topics where Takashi Murata is active.

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Featured researches published by Takashi Murata.


Anti-Cancer Drugs | 1999

Low-dose cytarabine-induced hepatic and renal dysfunction in a patient with myelodysplastic syndrome.

Masatsugu Tanaka; Heiwa Kanamori; Satoshi Yamaji; Aki Mishima; Hiroyuki Fujita; Shin Fujisawa; Takashi Murata; Hideyuki Koharazawa; Michio Matsuzaki; Hiroshi Mohri

We report a 49-year-old female patient with secondary myelodysplastic syndrome who developed liver dysfunction and acute renal failure caused by low-dose cytosine arabinoside (Ara-C) therapy. Treatment of low-dose Ara-C has widely been used for acute myelogeous leukemia and myelodysplastic syndrome, and it is thought to be a low toxicity except for myelosuppression. The patient complained of a transient adverse reaction in the second and third course of therapy. This rare case indicates that careful observation should be carried out during low-dose Ara-C therapy in view of allergic reactions.


Methods in molecular medicine | 2000

Immunoprecipitation to Determine JAK Kinase Activation in Response to Interleukins in Ovarian Cancer

Takashi Murata

In cytokine receptors, there is no consensus sequence motif for tyrosine and/or serine/threonine kinases in its intracellular domain (1). Cytokine receptors associate with and activate members of the Janus kinase family (JAK), which is phosphorylated following ligand binding (2). The JAK family consists of four kinase members, JAK1, JAK2, JAK3, and Tyk2. Recently, we have shown that in ovarian cancer cell lines, many IL-4 receptors were expressed and IL-4 inhibited the proliferation of ovarian carcinoma cell lines (3). Moreover, IL-4 induced the phosphorylation of JAK1, JAK2, Tyk2, STAT6, and IRS-1 proteins following ligand-receptor interaction (4).


Internal Medicine | 2018

Importance of the Average Glucose Level and Estimated Glycated Hemoglobin in a Diabetic Patient with Hereditary Hemolytic Anemia and Liver Cirrhosis

Rieko Nakatani; Takashi Murata; Takeshi Usui; Koki Moriyoshi; Toshiki Komeda; Yuichi Masuda; Maiko Kakita-Kobayashi; Tetsuya Tagami; Shinsaku Imashuku; Shigeo Kono; Kazunori Yamada; Akira Shimatsu

Glycated hemoglobin (HbA1c) is a widely used marker of glycemic control but can be affected by hemolytic anemia. Glycated albumin (GA) is also affected in patients with liver cirrhosis. We herein report the assessment of glycemic control in a 41-year-old man with dehydrated hereditary stomatocytosis and a PIEZO1 gene mutation complicated by diabetes mellitus and liver cirrhosis due to hemochromatosis. The estimated HbA1c calculated from the average glucose level obtained by continuous glucose monitoring or by self-monitoring of blood glucose was useful for evaluating the glycemic control in this patient, as HbA1c and GA were unreliable due to the coexisting conditions.


Diabetes Research - Open Journal | 2015

Impaired Awareness of Hypoglycemia and Driving Mishaps in Patients with Type 1 Diabetes Mellitus: A Multi-center Survey in Japan

Naoki Sakane; Kazuhiko Kotani; Kokoro Tsuzaki; Masami Nishi; Kaoru Takahashi; Takashi Murata; Kazunori Yamada; Kentaro Okazaki; Katsuyuki Yanagisawa; Nobuichi Kuribayashi; Yasuo Totsuka; Toru Hiyoshi; Motoji Naka; Yuji Aoki; Masako Waki; Haruko Kitaoka; Ikki Shimizu; Hiroaki Miyaoka; Akira Okada; Toshikazu Yamamoto

Naoki Sakane1*, Kazuhiko Kotani1,2, Kokoro Tsuzaki1, Masami Nishi1,20, Kaoru Takahashi1,3, Takashi Murata4, Kazunori Yamada4, Kentaro Okazaki5, Katsuyuki Yanagisawa6, Kenichi Yamada7, Nobuichi Kuribayashi8, Yasuo Totsuka9, Toru Hiyoshi10, Motoji Naka11, Masatake Sugimoto12, Yuji Aoki13, Masako Waki14, Miyuki Furuya15, Haruko Kitaoka16, Mariko Oishi17, Ikki Shimizu18, Hiroaki Miyaoka19, Akira Okada20 and Toshikazu Yamamoto21


American Journal of Hematology | 1993

Triclonal gammopathy (IgAk, IgGk, and IgMk) in a patient with plasmacytoid lymphoma derived from a monoclonal origin

Takashi Murata; Hiroyuki Fujita; Hiroshi Harano; Masaya Hukawa; Heiwa Kanamori; Michio Matsuzaki; Hiroshi Mohri; Jun Kudoh; Nobuyoshi Shimizu; Takao Okubo


Internal Medicine | 1999

De novo acute myelogenous leukemia with trilineage myelodysplasia associated with t(8;21)(q22;q22).

Shin Fujisawa; Jun-Ichi Togawa; Masatsugu Tanaka; Hideyuki Koharazawa; Mami Aoba; Hiroyuki Fujita; Takashi Murata; Heiwa Kanamori; Michio Matsuzaki; Hiroshi Mohri; Yoshiaki Ishigatsubo


Biomedical Sciences | 2017

Accuracy of a Novel “Factory-Calibrated” Continuous Glucose Monitoring Device in Normal Glucose Levels: A Pilot Study

Takashi Murata; Shinsuke Nirengi; Yaeko Kawaguchi; Shin Sukino; Tomokazu Watanabe; Naoki Sakane


Archive | 2014

Fear of Hypoglycemia and Patient-Physician Communication in Adult Patients with Type 1 Diabetes Mellitus

Naoki Sakane; Kazuhiko Kotani; Kokoro Tsuzaki; Masami Nishi; Kaoru Takahashi; Takashi Murata; Kazunori Yamada; Kentaro Okazaki; Katsuyuki Yanagisawa; Kenichi Yamada; Nobuichi Kuribayashi; Motoji Naka; Masatake Sugimoto; Yuji Aoki; Masako Waki; Miyuki Furuya; Haruko Kitaoka; Mariko Oishi; Toshikazu Yamamoto


The Japanese journal of clinical hematology | 1999

Successful Emergency Operation for Subdural Hematoma and Acute Epidural Hematoma in a Patient with Acute Promyelocytic Leukemia

Satoshi Yamaji; Heiwa Kanamori; Masatsugu Tanaka; Aki Mishima; Hideyuki Koharazawa; Hiroyuki Fujita; Shin Fujisawa; Takashi Murata; Michio Matsuzaki; Hiroshi Mohri; Yoshiaki Ishigatsubo


Archive | 2014

Impaired Awareness of Hypoglycemia in Insulin-Treated Patients with Type 2 Diabetes

Naoki Sakane; Kazuhiko Kotani; Kokoro Tsuzaki; Masami Nishi; Kaoru Takahashi; Takashi Murata; Kazunori Yamada; Kentaro Okazaki; Katsuyuki Yanagisawa; Kenichi Yamada; Nobuichi Kuribayashi; Motoji Naka; Masatake Sugimoto; Yuji Aoki; Masako Waki; Miyuki Furuya; Haruko Kitaoka; Mariko Oishi; Toshikazu Yamamoto

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Heiwa Kanamori

Yokohama City University

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Hiroshi Mohri

Aaron Diamond AIDS Research Center

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Masatsugu Tanaka

Tokyo Medical and Dental University

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