Takashi Nishitani

A synthesis of geminally functionalized heterocyclic aminocarboxylic acids by cycloaddition of ethyl N-acetyl-α,β-dehydroalaninate with 1,3-dipoles

Abstract 1,3-Dipolar cycloaddition of α,β-dehydroalaninate with dipoles proceeded with high regioselectivity to afford the title compounds in good yields.

A novel synthesis of 5-fluorouracil derivatives having oxacycloalkane moieties

Abstract 5-Fluorouracil derivatives having oxacycloalkane moieties were synthesized in good yields by the reaction of trimethylsilyloxyalkanal dialkyl acetals with 2,4-bis(trimethylsilyl)-5-fluorouracil in the presence of SnCl 4 .

A two-step synthesis of 2-exo-substituted 2-endo-aminonorbornenes from 2-acetamidonorbornene-2-carboxylic acids

Abstract 2-exo-Substituted 2-endo-acetamidonorbornenes (3) were synthesized in a two-step procedure from 2-acetamidonorbornene-2-carboxylic acids (1, 1′) with exceedingly high exo-selectivities based on a new approach involving anodic decarboxylation followed by organoaluminum-promoted nucleophilic substitution on 2-endo-acetamido-2-exo-methoxynorbornene (2).

A synthesis of 2-exo-substituted 2-endo-aminonorbornenes: Organoaluminum-promoted nucleophilic substitution on 2-endo-acetamido-2-exo-methoxynorbornene

A variety of 2-exo-substituted 2-endo-acetamidonorbornenes (2a–g) were synthesized in exceedingly high exo selectivities by organoaluminum-promoted nucleophilic substitution on 2-endo-acetamido-2-exo-methoxynorbornene (1).