Taleb H. Al-Tel

Synthesis of polyfunctionalized bis-annulated pyranosides: Useful intermediates for triquinane synthesis

Abstract A mild method for the synthesis of bis-cyclopentanoids on carbohydrate templates using the Pauson-Khand reaction is described.

Expeditious entries to chiral furanoids via pyranose annulation

Abstract A facile synthesis of polysubstituted ( Z )-tetrahydrofurylidenes using anhydrosugars is described. The ( Z )-compounds can be conveniently isomerized to the ( E )-products. The regiochemistry of the annulation reaction can be reversed by judicious choice of the leaving groups.

A useful regioselective approach to episulfides via cis-oriented anhydro triflate sugars

An efficient method for the regioselective synthesis of episulfides, showing remarkable proteinase-inhibiting activity, from cis-oriented anhydro triflate sugars is decribed.

AN EFFICIENT ROUTE TO REGIO- AND STEREOSELECTIVE SYNTHESIS OF 3-AMINO-3-DEOXY SUGARS

Abstract Starting from the trans-oriented hydroxy-epoxy pentoses (1, 8 and 15) and benzoylisocyanate a regio- and stereoselective route via the benzoylcarbamate intermediates 2, 9 and 16 to the 3-amino-3-deoxy sugars 7, 14 and 18 is described.

A new strategy for carbohydrate-based syntheses of oxaspiro-multichiral systems: An alternative route to pyranosidic homologation

Abstract A new strategy for the syntheses of polyfunctionalized oxaspiro variants using furan and the keto sugars 1 and 6 is described. Also, the resulting satellite ring represents an alternative route to homologated pyranosides.

Carbohydrates to carbocycles: Syntheses of polysubstituted chiral furanoids via oxirane ring opening

Abstract A new and effecient route to chiral furanoids through oxirane ring opening by the dianions of β-dicarbonyl compounds followed by intramolecular ring-closure is described. Furthermore, the syntheses of γ-lactones fused at C-2 and C-3 of the pyranosidic ring is also achieved.

Chiral δ-lactones via Pyranose-annulation

Abstract The syntheses of chiral δ-lactones 6, 10, 11a,b and 12 from anhydro riboses 1 and 7a,b are described.