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Featured researches published by Tang Xican.


Drug Development Research | 1996

Recent studies on traditional Chinese medicinal plants

Zhu Dayuan; Bai Donglu; Tang Xican

This review will discuss several new drugs which were discovered and developed in recent years from traditional Chinese medicines by the Shanghai Institute of Materia Medica. Huperzine A was isolated from Huperzia serrata, a plant used for the treatment of contusion, strain, haematuria, and swelling in Chinese folk medicine. Pharmacological studies have indicated that huperzine A has powerful and reversible anticholinesterase activity. Y‐maze methods have shown that huperzine A improves learning and retrieval processes, and facilitates memory retention. Huperzine A is used to treat patients with myasthenia gravis and Alzheimers disease in China. Sarmentosin, a cyanogenic glucoside was isolated from the whole plant of Sedum sarmentosium. This plant has long been used to treat hepatitis by folk medicine. Sarmentosin significantly lowers the SGPT level of patients suffering from chronic viral hepatitis, and shows a suppressive effect on cell‐mediated immune responses in mice. The root of Aconitum is well known in traditional Chinese medicine. Many Aconitum alkaloids have been isolated. Most show potent bioactivities, but with severe toxicity. Recently, some alkaloids such as 3‐acetylaconitine, lappaconitine, have shown significant anesthetic activity and exhibit a higher therapeutic index. Guan‐fu base A was isolated from the tuber root of Aconitum coreanum. Guan‐fu base A has antiarrhythmic action and is now in clinical trials. Drug Dev. Res. 39:147–157.


Bioorganic & Medicinal Chemistry Letters | 1998

Synthesis and acetylcholinesterase inhibitory activity of (±)-14-fluorohuperzine A

Zeng Fanxing; Jiang Hualiang; Tang Xican; Chen Kaixian; Ji Ruyun

Abstract The synthesis of (±)-14-Fluorohuperzine A has been accomplished and the ability of this agent to inhibit acetylcholinesterase has been measured. Taking into account its racemic form, this compound exhibits 62 times less potent activity than natural (−)-huperzine A.


Archive | 2003

Tetrahydroquinoline ketopiperidine compounds and their prepn and use

Cai Maojun; Shen Jingkang; Tang Xican


Chinese Journal of New Drugs and Clinical Remedies | 2006

Review on clinical application of huperzine A in China

Tang Xican


Archive | 2014

CAFFEOYL SUBSTITUTED PENTACYCLIC TRITERPENE DERIVATIVE AND USE THEREOF

Zhao Weimin; Zhang Haiyan; Wang Hongmin; Tang Xican; Wu Jian; Ruan Zhi; Li Jinlong; Fu Yan


Chinese Journal of Pharmacology and Toxicology | 1987

Anti-inflammatory and analgesic actions of yunaconitine

Tang Xican


Archive | 2015

High activity cedar seed extract and applications thereof

Ye Yang; Tang Xican; Zhang Haiyan; Yao Sheng; Wang Wei; Ji Ping


Archive | 2015

Cedar seed/cedar seed extract and applications thereof

Ye Yang; Tang Xican; Zhang Haiyan; Yao Sheng; Wang Wei; Ji Ping


Archive | 2014

Fluorine-substituted cyclic amine compounds and preparation method thereof, drug composition, and uses of fluorine-substituted cyclic amine compounds

Liu Hong; Zhang Haiyan; Zhou Yu; Fu Yan; Jiang Hualiang; Tang Xican; Chen Kaixian


Archive | 2014

Application of (3R)-des-O-methyl lasiodiplodin in preparation of drugs for preventing or treating depression

Zhang Haiyan; Guo Yuewei; Tang Xican; Gong Jingxu; Wang Wei; Jiang Chengshi

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Zhu Dayuan

Chinese Academy of Sciences

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Jiang Shanhao

Chinese Academy of Sciences

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Wang Wei

Chinese Academy of Sciences

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Chen Kaixian

Chinese Academy of Sciences

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Jiang Hualiang

Chinese Academy of Sciences

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Bai Donglu

Chinese Academy of Sciences

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Guo Yuewei

Sun Yat-sen University

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Ji Ruyun

Chinese Academy of Sciences

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Liu Hong

Chinese Academy of Sciences

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