Tatsuo Ishikawa

Studies on the causes of deaths from esophageal carcinoma

Statistics on the causes for deaths of 638 patients operated on in our department for resection of cancer of the intrathoracic esophagus (squamous cell carcinoma) during the period from 1959–1979 showed that the major causes for direct operative deaths were pyothorax, pulmonary complications, failure of the sutures, and postoperative hemorrhage. Among operation survivors, recurrence was the most frequent cause of death, responsible for the deaths of as many as 80% of less‐than‐five‐year survivors; and recurrence in the cervical, supraclavicular fossa, and superior mediastinal lymph nodes and that in the other organs were the frequent causes for the deaths of two‐ to three‐year survivors. Pulmonary complications were the causes for the deaths of 50%, and recurrence for the deaths of 30% of five‐ to ten‐year survivors. Recurrence in the digestive organs other than the esophagus and cardiovascular diseases were the frequent causes for the deaths of more‐than ten‐year survivors, while none of these survivors died of recurrence.

The effect of copper(II) on the formation of γ-FeOOH

Abstract Various γ-FeOOH samples have been synthesized by air oxidation of FeSO 4 solution with or without addition of Cu(II) (0–46 at.%Cu/Fe) and examined by X-ray diffraction, electron-microscopic observation, BET surface area determination, infra red absorption, DTA and chemical analyses. A destructive action of doped Cu(II) ions on the crystal formation was apparently recognized and discussed based on the crystallographic structure. The possible mechanism of crystallization of γ-FeOOH appears to differ between pure and Cu-doped γ-FeOOH, particularly one containing nearly 50%Cu.

CLINICAL AND EXPERIMENTAL STUDY OF BESTATIN FOR ESOPHAGEAL CANCER

Publisher Summary This chapter describes a clinical and experimental study of bestatin for esophageal cancer. The schedule of preoperative combined therapy for patients with esophageal cancer in department is shown. It was found that although irradiation and bleomycin were principally administered at the end of routine examination upon admission, the immunotherapeutic agent was given at the moment of admission and the dose of bestatin was 30 mg/day from admission to the day before surgery. The effectiveness was evaluated clinically according to radiographic features observed 7–10 days after the end of preoperative combined therapy in comparison with those observed upon admission. The total dose of bleomycin was 100 mg and that of bestatin was approximately 1000 mg though it was influenced by the duration from admission to surgery. After such preoperative treatment, the surgically resected specimens were investigated histopathologically for therapeutic effects and all revealed an effectiveness of Ef2, 3. It was found that the effective rate was 100% and more than 2/3 of cancer cells went into degeneration and necrosis.

The effect of chromium ions on the decomposition of colloidal ferrous hydroxide

Abstract The effect of Cr2+ and Cr3+ on the decomposition of Fe(OH)2 colloid was examined at pH 6.5–12.5 and 30–55°C by determining the rate of H2 evolved. The rate of H2 evolution increases with the Cr 2+ Fe 2+ ratio and temperature. The Cr3+ showed no decomposing effect at similar conditions. The addition of Cr(OH)2 colloid to Fe(OH)2 colloid showed the decomposition to a less extent, but without any dependence on the Cr Fe ratio. Pure Fe(OH)2 and Cr(OH)2 were stable at pH 12 for a long period. With reference to the X-ray diffraction and electron microscope observation, the decomposition products of Fe(OH)2 in the presence of Cr2+ were entirely amorphous. The magnetic susceptibility of these products, contrary to general belief, gave no evidence of formation of Fe3O4.