Teresa Deinlein

The use of dermatoscopy in diagnosis and therapy of nonmelanocytic skin cancer.

Today, dermatoscopy is an integral part of every clinical skin examination, as it markedly enhances the early detection of melanocytic and nonmelanocytic skin cancer (NMSC) compared to naked‐eye inspection. Besides its diagnostic use, this noninvasive method is increasingly important in the selection of as well as the response assessment to various therapies used for NMSC, including basal cell carcinoma, actinic keratoses, squamous cell carcinoma, and also rare tumors such as Merkel cell carcinoma, angiosarcoma, or dermatofibrosarcoma protuberans. Thus, dermatoscopy is a valid tool for the preoperative assessment of tumor margins in basal cell carcinoma, but also for follow‐up of actinic keratoses after topical treatment. The present article presents an overview on the use of dermatoscopy in the diagnosis and therapy of various types of NMSC.

Rapid response of metastatic cutaneous squamous cell carcinoma to pembrolizumab in a patient with xeroderma pigmentosum: Case report and review of the literature

A 48-year old patient with known xeroderma pigmentosum was referred to our skin cancer unit because of the recent development of histopathologically verified squamous cell carcinoma (SCC) lymph node metastasis on her left supraclavicular region. A whole body PET-CT showed additional abdominal and inguinal lymph node metastases. Her medical history included, in addition to several minimal surgeries of early forms of keratinocyte skin cancer, a poorly differentiated cutaneous SCC (cSCC) with invasion into the lymphatic vessels on her left tight, which was treated with wide surgical excision 5 years before. Moreover, she suffered from an incipient renal insufficiency not requiring current treatment. On whole body examination, multiple pigmented freckles and actinic keratoses but no other forms of skin cancer were detected. The supracervical lymph node metastasis presented as indurated, infiltrating

Der Einsatz der Dermatoskopie in der Diagnose und Therapie von nichtmelanozytären Hautkrebsformen: Dermatoskopie nichtmelanozytärer Hautkrebsformen

Die Dermatoskopie stellt heute einen integrativen Teil jeder klinischen Hautkrebsuntersuchung dar, da sie die Früherkennung von melanozytären und nichtmelanozytären Hautkrebsformen im Vergleich zur Untersuchung mit dem bloßen Auge deutlich verbessert. Neben ihrem diagnostischen Einsatz nimmt diese nichtinvasive Methode auch eine zunehmende Rolle in der Wahl und Bewertung unterschiedlicher Therapien von nichtmelanozytären Hauttumoren wie Basalzellkarzinomen, aktinischen Keratosen, Plattenepithelkarzinomen, aber auch seltenen Tumoren wie dem Merkelzellkarzinom, Angiosarkom oder dem Dermatofibrosarcoma protuberans ein. So ist die Dermatoskopie ein valides Werkzeug zur präoperativen Tumorrandbestimmung von Basalzellkarzinomen, kann aber auch zur Verlaufskontrolle nach erfolgter topischer Therapie von aktinischen Keratosen eingesetzt werden. In diesem Artikel soll ein Überblick über den Einsatz der Dermatoskopie in der Diagnose und Therapie unterschiedlicher Formen des nichtmelanozytären Hautkrebses gegeben werden.

Painful hemorrhagic bullae on the dorsal hands

A 57-year-old male patient presented at our outpatient clinic because of painful lesions on the dorsal aspect of his hands. He noticed the onset of these lesions about one week prior to presentation, and said that they had enlarged during the last few days. The mobility of his hands was severely limited due to increasing pain. Shortly before the lesions fi rst appeared, the patient had taken non-steroidal anti-infl ammatory drugs for three days because of headaches. His medical history was otherwise unremarkable, and the patient denied having had any other symptoms such as fever; he did not take any regular medications. Clinical examination revealed large, partly erosive, hemorrhagic bullae on both hands and the proximal parts of Painful hemorrhagic bullae on the dorsal hands Case for Diagnosis

The value of pre-surgical photography in the management of melanoma

While dermoscopy has become standard procedure in the diagnosis and management of patients with skin lesions, clinical and dermoscopic photographic documentation of lesions scheduled for biopsy are only infrequently performed in everyday practice [1-7]. Herein we present a case of a young woman who developed a re-pigmentation within the scar of an excised primary melanoma and highlight the importance of pre-surgical clinical photography in her management.

Hypomelanotic melanoma detected by the “little red riding hood sign” in a patient with neurofibromatosis type 1

Neurofibromatosis type 1 (NF1) is a genetic disorder commonly associated with an increased risk for development of malignancy, including skin cancers. Herein we describe a case of invasive melanoma occurring in a patient with NF1 and discuss the association between these two diseases, highlighting the importance of comparative clinical and dermoscopic approaches in this category of patients in which the detection of melanoma can be difficult because of the presence of multiple skin tumors.

Treatment of Primary and Metastatic Multifocal Mucosal Melanoma of the Oral Cavity with Imatinib

Background: Mucosal melanoma of the oral cavity is a rare entity and accounts for less than 1–3% of all melanomas. Contrary to cutaneous melanoma, primary oral melanoma more commonly harbors mutations in c-KIT. Methods: A 64-year-old man presented with asymptomatic, multiple, brown-to-black macules in the oral cavity. A biopsy was taken and histopathology exhibited mucosal melanoma. In molecular analysis, a c-KIT mutation was proven and a CT scan revealed pulmonary metastases. Due to the multifocality of the lesions, the metastases, and the mutation status, a therapy with imatinib was initiated. Results: After 1 year of therapy, progressive disease in the lung was noticed. Therefore, the therapy was switched to a PD-1 antagonist and a CTL-4 antibody. Conclusions: Our case suggests that imatinib may be considered as first-line treatment for both locally advanced and distant primary multifocal oral melanoma, for which surgery or radiotherapy of the primary tumor is impossible.