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Thavalakulamgara K. Sasikumar

Schering-Plough

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Publication

Featured researches published by Thavalakulamgara K. Sasikumar.

Bioorganic & Medicinal Chemistry Letters | 2009

Tricyclic thienopyridine-pyrimidones/thienopyrimidine-pyrimidones as orally efficacious mGluR1 antagonists for neuropathic pain.

Thavalakulamgara K. Sasikumar; Li Qiang; Duane A. Burnett; William J. Greenlee; Cheng Li; Larry Heimark; Birendra N. Pramanik; Mariagrazia Grilli; Rosalia Bertorelli; Gianluca Lozza; Angelo Reggiani

Introduction of small unsaturated alkylamino groups at the 4-position of the A-ring of the tricyclic framework (triazafluorenone) afforded extremely potent and selective mGluR1 antagonists with desirable properties. Compounds 11q and 11s are active in the SNL pain model with ED(50)s 3.3 and 6.4 mg/kg respectively. Metabolic outcome of propargyl amino moiety was studied.

Bioorganic & Medicinal Chemistry Letters | 2006

Hydrazides of clozapine: a new class of D1 dopamine receptor subtype selective antagonists.

Thavalakulamgara K. Sasikumar; Duane A. Burnett; Hongtao Zhang; April Smith-Torhan; Ahmad Fawzi; Jean E. Lachowicz

Archive | 2005

Tricyclic compounds and their use as mglur1 antagonists

Julius J. Matasi; Deen Tulshian; Duane A. Burnett; Wen-Lian Wu; Peter Korakas; Lisa S. Silverman; Thavalakulamgara K. Sasikumar; Li Qiang; Martin Domalski

Bioorganic & Medicinal Chemistry Letters | 2006

Tetrahydroisoquinolines as MCH-R1 antagonists

Thavalakulamgara K. Sasikumar; Li Qiang; Wen-Lian Wu; Duane A. Burnett; William J. Greenlee; Kim O’Neill; Brian E. Hawes; M. van Heek; Michael P. Graziano

Bioorganic & Medicinal Chemistry Letters | 2006

Novel aminobenzimidazoles as selective MCH-R1 antagonists for the treatment of metabolic diseases.

Thavalakulamgara K. Sasikumar; Li Qiang; Duane A. Burnett; William J. Greenlee; Brian E. Hawes; Timothy J. Kowalski; Kim O’Neill; Brian Spar; Blair Weig

Archive | 2003

Spirosubstituted piperidines as selective melanin concentrating hormone receptor antagonists for the treatment of obesity

Duane A. Burnett; Wen-Lian Wu; Thavalakulamgara K. Sasikumar; Martin S. Domalski

Archive | 2009

mGluR1 Antagonists as Therapeutic Agents

Julius J. Matasi; Deen Tulshian; Duane A. Burnett; Wen-Lian Wu; Peter Korakas; Lisa S. Silverman; Thavalakulamgara K. Sasikumar; Li Qiang; Martin S. Domalski

Bioorganic & Medicinal Chemistry Letters | 2006

Synthesis and structure–activity relationships of piperidine-based melanin-concentrating hormone receptor 1 antagonists

Wen-Lian Wu; Duane A. Burnett; Richard Spring; Li Qiang; Thavalakulamgara K. Sasikumar; Martin S. Domalski; William J. Greenlee; Kim O’Neill; Brian E. Hawes

Archive | 2004

Biaryltetrahydroisoquinoline piperidines as selective MCH receptor antagonists for the treatment of obesity and related disorders

Thavalakulamgara K. Sasikumar; Wen-Lian Wu; Duane A. Burnett; Li Qiang

Archive | 2004

Aminobenzimidazoles as selective melanin concentrating hormone receptor antagonists for the treatment of obesity and related disorders

Thavalakulamgara K. Sasikumar; Duane A. Burnett

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Collaboration

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Duane A. Burnett

Merck

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Li Qiang

Schering-Plough

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Wen-Lian Wu

Merck

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William J. Greenlee

Merck

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Jing Su

Schering-Plough

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Brian E. Hawes

Schering-Plough

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Brian Mckittrick

Schering-Plough

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Deen Tulshian

Schering-Plough

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Julius J. Matasi

Merck

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Kim O’Neill

Schering-Plough

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