Wen-Lian Wu | Researchain

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Featured researches published by Wen-Lian Wu.

Bioorganic & Medicinal Chemistry Letters | 2002

Synthesis and structure-activity relationships of aminoalkylazetidines as ORL1 receptor ligands.

Wen-Lian Wu; Mary Ann Caplen; Martin S. Domalski; Hongtao Zhang; Ahmad Fawzi; Duane A. Burnett

A series of aminoalkylazetidines has been discovered as novel ORL1 receptor ligands. Structure-activity relationships have been investigated at the azetidine N and the alkyl side chain sites. Several potent and selective analogues have been identified.

Archive | 2006

Fused tetracyclic mglur1 antagonists as therapeutic agents

Duane A. Burnett; Wen-Lian Wu

Archive | 2002

Piperidine-based mch antagonists for treatment of obesity and cns disorders

Duane A. Burnett; Wen-Lian Wu

Bioorganic & Medicinal Chemistry Letters | 2006

Design and synthesis of orally efficacious benzimidazoles as melanin-concentrating hormone receptor 1 antagonists.

Wen-Lian Wu; Duane A. Burnett; Mary Ann Caplen; Martin S. Domalski; Chad E. Bennett; William J. Greenlee; Brian E. Hawes; Kim O’Neill; Blair Weig; Daniel J. Weston; Brian Spar; Timothy J. Kowalski

Bioorganic & Medicinal Chemistry Letters | 2006

Tetrahydroisoquinolines as MCH-R1 antagonists

Thavalakulamgara K. Sasikumar; Li Qiang; Wen-Lian Wu; Duane A. Burnett; William J. Greenlee; Kim O’Neill; Brian E. Hawes; M. van Heek; Michael P. Graziano

Archive | 2003

Spirosubstituted piperidines as selective melanin concentrating hormone receptor antagonists for the treatment of obesity

Duane A. Burnett; Wen-Lian Wu; Thavalakulamgara K. Sasikumar; Martin S. Domalski

Archive | 2009

mGluR1 Antagonists as Therapeutic Agents

Julius J. Matasi; Deen Tulshian; Duane A. Burnett; Wen-Lian Wu; Peter Korakas; Lisa S. Silverman; Thavalakulamgara K. Sasikumar; Li Qiang; Martin S. Domalski

Archive | 2004

2-substituted benzimidazole derivatives as selective melanin concentrating hormone receptor antagonists for the treatment of obesity and related disorders

Wen-Lian Wu; Duane A. Burnett; Mary Ann Caplen

Bioorganic & Medicinal Chemistry Letters | 2006

Synthesis and structure–activity relationships of piperidine-based melanin-concentrating hormone receptor 1 antagonists

Wen-Lian Wu; Duane A. Burnett; Richard Spring; Li Qiang; Thavalakulamgara K. Sasikumar; Martin S. Domalski; William J. Greenlee; Kim O’Neill; Brian E. Hawes

Archive | 2004