Thilo Elsässer

Modeling Heavy Ion Radiation Effects

IBT requires a consideration of the complex dependencies of the relative biological effectiveness (RBE). In this chapter, several approaches based on biophysical modeling are reviewed with an emphasis on the Local Effect Model, since this is the only biophysical model that has been used for treatment planning. Basic considerations, the comparison to experimental data, and the integration into a treatment planning system are summarized.

Noise Reduction in Low Dose DSA Imaging Using Pixel Adaptive SVD-Based Approach

In this work, a new method for noise reduction in low dose DSA imaging is presented. The algorithm extends an existing approach using the low rank nature of DSA image series to enable considerable reduction of radiation dose while maintaining low image noise level and preserving spatial resolution and temporal dynamics of the DSA series. The algorithm is based on the singular value decomposition (SVD) using a pixel adaptive approach for the noise reduction. For validation of the method an in vivo animal study is examined