Thomas G. Gant
Pfizer
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Publication
Featured researches published by Thomas G. Gant.
Bioorganic & Medicinal Chemistry Letters | 2009
Christopher John Helal; Zhijun Kang; John C. Lucas; Thomas G. Gant; Michael K. Ahlijanian; Joel B. Schachter; Karl E.G. Richter; James M. Cook; Frank S. Menniti; Kristin Kelly; Scot Mente; Jay Pandit; Natalie Hosea
Utilizing structure-based drug design, a 4-aminoimidazole heterocyclic core was synthesized as a replacement for a 2-aminothiazole due to potential metabolically mediated toxicity. The synthetic route utilized allowed for ready synthesis of 1-substituted-4-aminoimidazoles. SAR exploration resulted in the identification of a novel cis-substituted cyclobutyl group that gave improved enzyme and cellular potency against cdk5/p25 with up to 30-fold selectivity over cdk2/cyclin E.
Bioorganic & Medicinal Chemistry Letters | 2004
Christopher John Helal; Mark A. Sanner; Christopher B. Cooper; Thomas G. Gant; Mavis Diane Adam; John C. Lucas; Zhijun Kang; Stanley William Kupchinsky; Michael K. Ahlijanian; Bonnie Frances Tate; Frank S. Menniti; Kristin Kelly; Marcia Peterson
Archive | 2000
Thomas G. Gant; Mark C. Noe
Bioorganic & Medicinal Chemistry Letters | 2006
Blaise Lippa; Joel Morris; Matthew Corbett; Tricia Kwan; Mark C. Noe; Sheri L. Snow; Thomas G. Gant; Melchiorra Mangiaracina; Heather Anne Coffey; Barbara Foster; Elisabeth Knauth; Matthew D. Wessel
Archive | 2001
Thomas G. Gant; Glenn Robert Williams
Archive | 2005
Thomas G. Gant; Roger J. Hill; Hua Zhu Ke; Bruce Allen Lefker; James Paul O'malley
Archive | 1999
Thomas G. Gant
Archive | 2001
Thomas G. Gant; Glenn Robert Williams
Archive | 2007
Thomas G. Gant; Glenn Robert Williams; ロバート ウィリアムズ，グレン; ジー． ガント，トーマス
Archive | 2005
Thomas G. Gant; Glenn Robert Williams
