Thomas Michael Bare
AstraZeneca
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Publication
Featured researches published by Thomas Michael Bare.
Bioorganic & Medicinal Chemistry Letters | 2003
Dean G. Brown; Rebecca Urbanek; Thomas Michael Bare; Frances M. Mclaren; Carey Horchler; Megan Murphy; Gary Steelman; James Empfield; Janet Marie Forst; Keith J. Herzog; Wenhua Xiao; Martin C. Dyroff; Chi-Ming C. Lee; Shephali Trivedi; Kathy L. Neilson; Richard Alan Keith
Several members of the 7-chloro-2,3-dihydro-2-[1-(pyridinyl)alkyl]-pyridazino[4,5-b]quinoline-1,4,10(5H)-triones (2) have been identified as being potent and selective NMDA glycine-site antagonists. Increasing size of the alkyl substituent on the alpha-carbon led to a progressive decrease in binding affinity. Some of these analogues possess improved drug-like properties such as cellular permeability, solubility and oral absorption.
Archive | 1994
Thomas Michael Bare; Richard Bruce Sparks; James Empfield; Timothy Wayne Davenport; Jeffrey Alan Mckinney
Archive | 1994
Thomas Michael Bare; Timothy Davenport; James Empfield; Jeffrey A. McKinney; Richard Bruce Sparks
Archive | 2005
Thomas Michael Bare; Dean G. Brown; Megan Murphy; Rebecca Urbanek; Wenhua Xiao
Archive | 2005
Dean G. Brown; Wenhua Xiao; Rebecca Urbanek; Megan Murphy; Thomas Michael Bare
Archive | 2005
Thomas Michael Bare; Dean G. Brown; Megan Murphy; Rebecca Urbanek; Wenhua Xiao
Archive | 1994
Thomas Michael Bare; Timothy Davenport; James Empfield; Kinney Jeffrey Alan Mc; Richard Bruce Sparks
Archive | 1992
Thomas Michael Bare; Richard Bruce Sparks
Archive | 1992
Thomas Michael Bare; Richard Bruce Sparks
Archive | 1992
Thomas Michael Bare; Richard Bruce Sparks; マイケル ベア トーマス; ブルース スパークス リチヤード
