Wenhua Xiao | Researchain

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Featured researches published by Wenhua Xiao.

Bioorganic & Medicinal Chemistry Letters | 2003

Synthesis of 7-chloro-2,3-dihydro-2-[1-(pyridinyl)alkyl]-pyridazino[4,5-b]quinoline-1,4,10(5H)-triones as NMDA glycine-site antagonists

Dean G. Brown; Rebecca Urbanek; Thomas Michael Bare; Frances M. Mclaren; Carey Horchler; Megan Murphy; Gary Steelman; James Empfield; Janet Marie Forst; Keith J. Herzog; Wenhua Xiao; Martin C. Dyroff; Chi-Ming C. Lee; Shephali Trivedi; Kathy L. Neilson; Richard Alan Keith

Several members of the 7-chloro-2,3-dihydro-2-[1-(pyridinyl)alkyl]-pyridazino[4,5-b]quinoline-1,4,10(5H)-triones (2) have been identified as being potent and selective NMDA glycine-site antagonists. Increasing size of the alkyl substituent on the alpha-carbon led to a progressive decrease in binding affinity. Some of these analogues possess improved drug-like properties such as cellular permeability, solubility and oral absorption.

Journal of Medicinal Chemistry | 2007

Pyridazinoquinolinetriones as NMDA Glycine-Site Antagonists with Oral Antinociceptive Activity in a Model of Neuropathic Pain

Thomas M. Bare; Dean G. Brown; Carey Horchler; Megan Murphy; Rebecca Urbanek; Vernon Alford; Christine Barlaam; Martin C. Dyroff; James B. Empfield; Janet Marie Forst; Keith J. Herzog; Richard Alan Keith; Alan S. Kirschner; Chi-Ming C. Lee; Joseph James Lewis; Frances M. Mclaren; Kathy L. Neilson; Gary Steelman; Shephali Trivedi; Edward P. Vacek; Wenhua Xiao

Archive | 2005

Compound and method for the treatment of pain

Thomas Michael Bare; Dean G. Brown; Megan Murphy; Rebecca Urbanek; Wenhua Xiao

Archive | 2005

Substituted 1,2,5,10-tetrahydropyridazino [4,5-b]quinoline-1,10-dione compounds and methods for the treatment of pain

Dean G. Brown; Wenhua Xiao; Rebecca Urbanek; Megan Murphy; Thomas Michael Bare

Archive | 2005

DERIVADO DE PIRIDAZINOQUINOLINA E METODO PARA O TRATAMENTO DA DOR

Michael Bare Thomas; Gordon Brown Dean; Megan Murphy; Ann Urbanek Rebecca; Wenhua Xiao

Archive | 2005

PYRIDAZINO QUINOLINE DERIVATIVE AND METHOD FOR THE TREATMENT OF PAIN

Thomas Michael Bare; Dean G. Brown; Megan Murphy; Rebecca Urbanek; Wenhua Xiao

Archive | 2003

METODO Y COMPOSICION PARA EL TRATAMIENTO DEL DOLOR

Vernon Alford; Bare Thomas Michael; Brown Dean Gordon; Megan Murphy; Urbanek Rebecca Ann; Wenhua Xiao; Mclaren Frances Marie

Archive | 2001

7-CHLOR-4-HYDROXY-2-(2-PYRIDYLETHYL)-1,2,5,10-TETRAHYDROPYRIDAZINOi4,5-BöCHINOLIN-1,10-DIONE UND IHRE VERWENDUNG ZUR BEHANDLUNG VON SCHMERZEN 7 CHLORIDE-4-HYDROXY-2- (2-pyridylethyl) -1,2,5,10-TETRAHYDROPYRIDAZINOi4,5-BöCHINOLIN-1,10-DIONE AND THEIR USE IN THE TREATMENT OF PAIN

Dean G. Brown; Rebecca Urbanek; Megan Murphy; Wenhua Xiao; Frances M. Mclaren; Edward P. Vacek; Thomas M. Bare; Carey Horchler; Christine Barlaam; Gary Steelman; Vernon Alford

Archive | 2001

7-chloro-4-hydroxy-2- (2-pyridylethyl) -1,2,5,10-TETRAHYDROPYRIDAZINOi4,5-BöCHINOLIN-1,10-DIONE AND THEIR USE FOR THE TREATMENT OF PAIN

Dean G. Brown; Rebecca Urbanek; Megan Murphy; Wenhua Xiao; Frances M. Mclaren; Edward P. Vacek; Thomas M. Bare; Carey Horchler; Christine Barlaam; Gary Steelman; Vernon Alford

Archive | 2000