Thomas R. Boussie

Solid‐Phase Synthesis and Encoding Strategies for Olefin Polymerization Catalyst Libraries

Active polymerization catalysts, novel resin-bound diimine complexes of nickel(II) and palladium(II) are obtained by combinatorial synthesis and combined in a catalyst library. By tagging with fluorescent markers, the catalysts can be coded. Therefore, after cleavage of the tag from the polymer-coated resin, HPLC can be used to determine the pathway along which the products were formed.

Parallel solid-phase synthesis, screening, and encoding strategies for olefin-polymerization catalysts

Abstract A solid-phase protocol has been developed that allows for the parallel synthesis, screening, and chemical encoding of nickel (II) and palladium (II) olefin-polymerization catalysts. These catalysts display activity profiles comparable to the analogous homogeneous catalyst systems prepared by traditional methods. A chemical encoding strategy has also been developed which enables the chemical history of pooled solid-phase catalysts to be evaluated.

Festphasensynthese und Kodierung von Katalysatorbibliotheken für Olefinpolymerisationen

Aktive Polymerisationskatalysatoren sind die neuartigen, harzgebundenen Bisiminnickel(II)- und -palladium(II)-Komplexe, die durch kombinatorische Synthesen erhalten und zu einer Katalysatorbibliothek zusammengestellt wurden. Durch Einfugen von Fluoreszenzmarkern lassen sich die Katalysatoren kodieren, so das nach dem Abspalten der Marker vom polymerbeschichteten Harz HPL-chromatographisch zuruckverfolgt werden kann, nach welchem Syntheseverlauf die Produkte entstanden sind.