Vince Murphy

Solid‐Phase Synthesis and Encoding Strategies for Olefin Polymerization Catalyst Libraries

Active polymerization catalysts, novel resin-bound diimine complexes of nickel(II) and palladium(II) are obtained by combinatorial synthesis and combined in a catalyst library. By tagging with fluorescent markers, the catalysts can be coded. Therefore, after cleavage of the tag from the polymer-coated resin, HPLC can be used to determine the pathway along which the products were formed.

Parallel solid-phase synthesis, screening, and encoding strategies for olefin-polymerization catalysts

Abstract A solid-phase protocol has been developed that allows for the parallel synthesis, screening, and chemical encoding of nickel (II) and palladium (II) olefin-polymerization catalysts. These catalysts display activity profiles comparable to the analogous homogeneous catalyst systems prepared by traditional methods. A chemical encoding strategy has also been developed which enables the chemical history of pooled solid-phase catalysts to be evaluated.

High-throughput approaches to catalyst discovery.

High-throughput synthesis and screening approaches to catalyst discovery and optimization are systematically changing the way in which catalyst research is conducted. Increased rates of innovation, cost effectiveness, improved intellectual property, reduced time to market and an improved probability of success are some of the attractive features that demand consideration. Advances made over the past few years reveal that any initial skepticism is waning, and high-throughput approaches to catalyst discovery are now being implemented broadly in industrial and academic laboratories.

Festphasensynthese und Kodierung von Katalysatorbibliotheken für Olefinpolymerisationen

Aktive Polymerisationskatalysatoren sind die neuartigen, harzgebundenen Bisiminnickel(II)- und -palladium(II)-Komplexe, die durch kombinatorische Synthesen erhalten und zu einer Katalysatorbibliothek zusammengestellt wurden. Durch Einfugen von Fluoreszenzmarkern lassen sich die Katalysatoren kodieren, so das nach dem Abspalten der Marker vom polymerbeschichteten Harz HPL-chromatographisch zuruckverfolgt werden kann, nach welchem Syntheseverlauf die Produkte entstanden sind.

Synthesis, crystal structures and magnetic properties of salts containing bis[hydrotris(3,5-dimethyl-1-pyrazolyl)borate]iron(III)

Abstract The salts [Fe(C15H22N6B)2][PF6], [Fe(C15H22N6B)2][TCNQ]. THF and [Fe(C15H22N6B)2][FeBr4] have been prepared and the first two subjected to X-ray diffraction studies. In [Fe(C15H22N6B2][PF6] the coordination geometry around the Fe centre is almost perfectly octahedral, with the Fe N bond distances in the range 1.960(3)–1.970(3)A, which are typical distances for low spin iron(III) complexes. In [Fe(C15H22N6B)2][TCNQ]. THF the Fe N bond lengths lie in the range 1.980(3)–1.949(2)A, and there is essentially octahedral symmetry around the metal centre. In the case of [Fe(C15H22N6B)2][TCNQ]. THF the [TCNQ]− anions lie in rows perpendicular to the crystallographic bc-plane, these rows being separated by parallel rows of [Fe(C15H22N6B)2] cations. The solid state magnetic susceptibility data for these compounds obey the Curie law (χM =C/T) in the temperature range 6–300 K with μeff = 1.65, 2.55and5.39 μB for the three complexes respectively. None of these salts showed any evidence of short-range spin-spin interactions at low temperature.