Tibor Auer
University of Pécs
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Featured researches published by Tibor Auer.
Epileptic Disorders | 2008
Tibor Auer; Katalin Vetö; Tamás Dóczi; Sámuel Komoly; Vera Juhos; J. Janszky; Attila Schwarcz
AIMnTo visualize by ictal, functional MRI, the initial haemodynamic change (i.e. putative seizure-onset zone) and subsequent seizure spread during an epileptic seizure.nnnMETHODSnA 20-year-old woman was investigated during a simple partial seizure consisting of right-sided mouth clonus. An internal reference curve, correlated with signal change pixelwise, was applied to obtain correlation coefficient maps. The reference curve was shifted scan by scan to examine the correlation at each time point. To demonstrate seizure onset and propagation, a lag time map was produced showing the temporal sequence of activation in various brain regions.nnnRESULTSnfMRI analysis showed that the lower part of the insular cortex was activated first, and its signal alteration preceded the clinical beginning of the seizure (i.e. mouth clonus) by more than one minute. Most of the activations started before clinical seizure onset. The activation corresponding to the motor area of the right face showed only a 7.5 second-long, pre-ictal phase. BOLD signal alterations were also observed in the left caudate nucleus, left thalamus, along with various areas of the left cerebral and cerebellum hemispheres.nnnCONCLUSIONSnThe present study demonstrates a whole-brain activity simultaneously in time and space, during an epileptic seizure. Our results also support the existence of the pre-ictal state in epilepsy. Replication of our results would be of major interest for presurgical evaluation of patients with drug-resistant epilepsy.
Cell Biology International | 2006
Andrea Zsombok; Tibor Auer; Ferenc Gallyas
At the end of transcardial perfusions with ice‐cold physiological saline for 30 min or with isoosmotic potassium chloride for 5 min, but immediately before perfusion fixation, condenser‐discharge electric shocks were administered to rats through surface electrodes pressed onto the temporal muscles of the scalped skull. As a result, striking ultrastructural compaction came about in numerous neurons thinly scattered in certain brain areas. Its features displayed a high degree of similarity to those previously observed following the in vivo administration of the same kind of electric shocks. This surprising independence from the actual state of metabolism questions whether the ultrastructural compaction, induced either in vivo or post mortem, is the result of any cascade of enzyme‐mediated processes. On the other hand, a physical mechanism, phase transition propagated by non‐covalent free energy stored in a cytoplasmic gel structure, which was proposed recently to explain a mechanically induced similar ultrastructural compaction, appears to apply also to the present case.
Laterality | 2008
Tibor Auer; Attila Schwarcz; Mihály Aradi; Zsuzsa Kalmár; Clay Pendleton; Imre Janszky; Réka Horváth; Csaba Szalay; Tamás Dóczi; Sámuel Komoly; József Janszky
We aimed to determine the functional localisation of right–left discrimination (RLD) by functional MRI (fMRI). In this study, 16 male volunteers were examined. There were three task sessions: one active and two baseline tasks. During the baseline tasks participants were instructed to show numbers with their fingers. The first baseline task was performed with the right hand, the second one with the left hand. During the active (RLD) task participants were also instructed to show numbers. The difference between baseline and active tasks was that during the active task the hand with which the participant should perform the instruction was assigned randomly. Thus, participants were unaware which hand should be used before the instruction command. During RLD, activations occurred in the right-sided frontal, precuneus, postcentral, angular, lingual, and superior temporal gyri. Activations also appeared in the left-sided temporal gyri and precuneus. Of the activations, 76.7% appeared in the right hemisphere, 23.3% in the left hemisphere. Conclusively, we found that RLD is mainly related to the right hemisphere, and requires activation of the parieto-temporo-occipital junction and the visual system including cuneus, precuneus, and gyrus lingualis.
Headache | 2009
Tibor Auer; J. Janszky; Attila Schwarcz; Tamás Dóczi; Anita Trauninger; Balint Alkonyi; Sámuel Komoly; Zoltán Pfund
The authors report functional magnetic resonance imaging (fMRI) study data of a 60‐year‐old patient having short‐lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) syndrome. Three consecutive pain attacks were detected during the imaging session and strong brainstem activation was found. It was concluded that the brainstem can be involved in the pain signal transmission in SUNCT syndrome.
Journal of Magnetic Resonance Imaging | 2008
Gábor Bajzik; Tibor Auer; Péter Bogner; Miklós Aradi; Gyula Kotek; Imre Repa; Tamás Dóczi; Attila Schwarcz
To provide a straightforward method for metabolite quantitation in the brain. Tissue water concentration can be determined in a voxel by measuring T1 and it may provide an internal reference for the calculation of the metabolite concentrations.
Epileptic Disorders | 2007
Vanda Tóth; György Rásonyi; András Fogarasi; Norbert Kovács; Tibor Auer; J. Janszky
Ideggyogyaszati Szemle-clinical Neuroscience | 2007
Tibor Auer; Attila Schwarcz; J. Janszky; Horváth Z; Kosztolányi P; Tamás Dóczi
Ideggyogyaszati Szemle-clinical Neuroscience | 2008
Tibor Auer; Attila Schwarcz; Réka Horváth; Péter Barsi; J. Janszky
Archive | 2008
Tibor Auer; Péter Barsi; Beáta Bóné; Anna Angyalosi; Mihály Aradi; Csaba Szalay; Réka Horváth; Norbert Kovács; Gyula Kotek; András Fogarasi; Sámuel Komoly; Imre Janszky; Attila Schwarcz; J ´ ozsef Janszky
Archive | 2007
Tibor Auer; Attila Schwarcz; Erzsébet Ezer; Endre Czeiter; Mihály Aradi; Sándor Hudvágner; J. Janszky; András Büki; Tamás Dóczi