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Featured researches published by Tiffany Turner.


Bioorganic & Medicinal Chemistry Letters | 2000

1-Phenyl-5-pyrazolyl ureas: potent and selective p38 kinase inhibitors

Jacques Dumas; Holia Hatoum-Mokdad; Robert Sibley; Bernd Riedl; William J. Scott; Mary Katherine Monahan; Timothy B. Lowinger; Catherine Brennan; Reina Natero; Tiffany Turner; Jeffrey S Johnson; Robert W. Schoenleber; Ajay Bhargava; Scott Wilhelm; Timothy J Housley; Gerald Ranges; Alka Shrikhande

Inhibitors of the MAP kinase p38 are potentially useful for the treatment of arthritis and osteoporosis. Several 2,3-dichlorophenyl ureas were identified as small-molecule inhibitors of p38 by a combinatorial chemistry effort. Optimization for cellular potency led to the discovery of a new class of potent and selective p38 kinase inhibitors, exemplified by the 1-phenyl-5-pyrazolyl urea 7 (IC50 = 13 nM).


Archive | 1998

INHIBITION OF p38 KINASE USING SYMMETRICAL AND UNSYMMETRICAL DIPHENYL UREAS

Scott Miller; Martin Osterhout; Jacques Dumas; Uday Khire; Timothy B. Lowinger; William J. Scott; Roger A. Smith; Jill E. Wood; David E. Gunn; Holia Hatoum-Mokdad; Marell Rodriguez; Robert Sibley; Ming Wang; Tiffany Turner; Catherine Brennan


Archive | 1998

Inhibition of raf kinase using symmetrical and unsymmetrical substituted diphenyl ureas

Scott Miller; Martin Osterhout; Jacques Dumas; Uday Khire; Timothy B. Lowinger; Bernd Riedl; William J. Scott; Roger A. Smith; Jill E. Wood; David E. Gunn; Ming Wang; Tiffany Turner; Catherine Brennan


Archive | 1998

HEMMUNG DER p38 KINASE UNTER VERWENDUNG VON SYMMETRISCHEN UND ASYMMETRISCHEN DIPHENYLHARNSTOFFEN

Scott Miller; Martin Osterhout; Jacques Dumas; Uday Khire; Bruno Lowinger; Bernd Riedl; J Scott; A Smith; E Wood; David E. Gunn; Holia Hatoum-Mokdad; Robert Sibley; Ming Wang; Tiffany Turner; Catherine Brennan


Archive | 2005

INIBICAO DE QUINASE P38 UTILIZANDO DIFENILUREIAS SIMETRICAS E ASSIMETRICAS

Scott William J; David Gunn; Scott Miller; Martin Osterhout; Jacques Dumas; Uday Khire; Bruno Lowinger Timothy; Bernd Riedl; Smith Roger A; Wood Jill E; Holia Hatoum-Mokdad; Robert Sibley; Ming Wang; Tiffany Turner


Archive | 1998

HEMMUNG DER p38 KINASE UNTER VERWENDUNG VON SYMMETRISCHEN UND ASYMMETRISCHEN DIPHENYLHARNSTOFFEN Inhibition of p38 Kinase USING SYMMETRIC AND ASYMMETRIC DIPHENYLHARNSTOFFEN

Scott Miller; Martin Osterhout; Jacques Dumas; Uday Khire; Bruno Lowinger; Bernd Riedl; Jason Douglas Scott; A Smith; E Wood; David Gunn; Holia Hatoum-Mokdad; Robert Sibley; Ming Wang; Tiffany Turner; Catherine Brennan


Archive | 1998

Inhibition de raf kinase au moyen de diphenylurees substituees symetriques et asymetriques

Scott Miller; Martin Osterhout; Jacques Dumas; Uday Khire; Timothy B. Lowinger; Bernd Riedl; William J. Scott; Roger A. Smith; Jill E. Wood; David Gunn; Ming Wang; Tiffany Turner; Catherine Brennan


Archive | 1998

Inhibition of p38 Kinase USING symmetric and asymmetric DIPHENYLHARNSTOFFEN

Catherine Brennan; Jacques Dumas; David Gunn; Holia Hatoum-Mokdad; Uday Khire; Bruno Lowinger; Scott Miller; Martin Osterhout; Bernd Riedl; J. William Guilford Scott; Robert Sibley; A. Roger Madison Smith; Tiffany Turner; Ming Wang; E. Jill Wood


Archive | 1998

INHIBITION DE LA KINASE p38 PAR DES DIPHENYL-UREES SYMETRIQUES ET DISSYMETRIQUES

Scott Miller; Martin Osterhout; Jacques Dumas; Uday Khire; Timothy B. Lowinger; Bernd Riedl; William J. Scott; Roger A. Smith; Jill E. Wood; David Gunn; Holia Hatoum-Mokdad; Robert Sibley; Ming Wang; Tiffany Turner; Catherine Brennan


Archive | 1998

Inhibition of p38 kinase using symmetrical and asymmetrical diphenylurinstoffer

Uday Khire; Bernd Riedl; William J. Scott; Roger A. Smith; Jill E. Wood; David Gunn; Holia Hatoum-Mokdad; Scott Miller; Martin Osterhout; Jacques Dumas; Timothy B. Lowinger; Robert Sibley; Ming Wang; Tiffany Turner; Catherine Brennan

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