Todd A. Reinhart | Researchain

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Featured researches published by Todd A. Reinhart.

The Journal of Infectious Diseases | 1997

Simian Immunodeficiency Virus Burden in Tissues and Cellular Compartments during Clinical Latency and AIDS

Todd A. Reinhart; Michael J. Rogan; David Huddleston; Dianne M. Rausch; Lee E. Eiden; Ashley T. Haase

In the course of human immunodeficiency virus infection or of the related simian immunodeficiency virus (SIV), progression to AIDS is associated with high virus burdens in blood. How virus burden in the bloodstream is related to virus burden in tissue reservoirs was addressed in an animal model of rhesus macaques infected with SIV. In situ hybridization and quantitative image analysis were used to quantitate virus burden. Animals who developed AIDS had high levels of virus production and storage in lymphoid tissue reservoirs and evidence of productive infection of macrophages in the nervous system. With the quantitative approach described, it should be possible to design and assess the impact of treatment and shed light on the outstanding issues in pathogenesis.

Annals of Neurology | 1996

Human T‐lymphotropic virus type I‐associated myelopathy and tax gene expression in CD4+ T lymphocytes

Takashi Moritoyo; Todd A. Reinhart; Hiroyoko Moritoyo; Eiichi Sato; Shuji Izumo; Mitsuhiro Osame; Ashley T. Haase

Nature Medicine | 1997

A NEW APPROACH TO INVESTIGATING THE RELATIONSHIP BETWEEN PRODUCTIVE INFECTION AND CYTOPATHICITY IN VIVO

Todd A. Reinhart; Michael J. Rogan; Gregory A. Viglianti; Dianne M. Rausch; Lee E. Eiden; Ashley T. Haase

Virology | 1995

Single cell transcript analysis of human immunodeficiency virus gene expression in the transition from latent to productive infection

Hairong Peng; Todd A. Reinhart; Ernest F. Retzel; Katherine Staskus; Mary Zupancic; Ashley T. Haase

Journal of Virology | 1998

Tracking Members of the Simian Immunodeficiency Virus deltaB670 Quasispecies Population In Vivo at Single-Cell Resolution

Todd A. Reinhart; Michael J. Rogan; Angela M. Amedee; Michael Murphey-Corb; Dianne M. Rausch; Lee E. Eiden; Ashley T. Haase

Journal of Virology | 1993

Distinct superinfection interference properties yet similar receptor utilization by cytopathic and noncytopathic feline leukemia viruses.

Todd A. Reinhart; Ananta K. Ghosh; Edward A. Hoover; James I. Mullins

Journal of Virology | 1993

Interference with superinfection and with cell killing and determination of host range and growth kinetics mediated by feline leukemia virus surface glycoproteins.

Bruce S. Kristal; Todd A. Reinhart; Edward A. Hoover; James I. Mullins

Archives of Pathology & Laboratory Medicine | 1998

Human immunodeficiency virus-2 infection in baboons is an animal model for human immunodeficiency virus pathogenesis in humans.

Christopher P. Locher; Susan W. Barnett; Brian Herndier; David J. Blackbourn; Gustavo Reyes-Terán; Krishna K. Murthy; Kathleen M. Brasky; Gene B. Hubbard; Todd A. Reinhart; Ashley T. Haase; Jay A. Levy

Virology | 1996