Tomasz Smektała

Preoperative, intraoperative, and postoperative complications in orthognathic surgery: a systematic review.

ObjectivesThe aim of this study was to determine whether orthognathic surgery is associated with any complications, and what type of complications may occur.Materials and methodsData were obtained using PubMed (MEDLINE), ISI Web of Knowledge, Ovid, Cochrane Library, Embase Library, and an additional manual search. The titles and abstracts of the electronic search results were screened and evaluated by two observers for eligibility according to the inclusion and exclusion criteria.ResultsA total of 1924 articles were identified, and we retained 44 articles for the final analysis. The Prisma diagram flowchart demonstrates our selection scheme. For the purpose of this study, the Cochrane data extraction form was modified. One review author extracted data from the included studies, and the second author checked all of the forms. The hierarchy of evidence classification from the UK NHS Centre for Reviews and Dissemination was used to assess the level of evidence for the retrieved studies.ConclusionsAn evaluation of the obtained studies revealed the existence of a large number of varied complications associated with orthognathic surgery procedures.Clinical relevanceOral and maxillofacial surgeons, orthodontists, and the surgical team need to prevent such complications during preoperative, intraoperative, and postoperative periods to increase the safety of orthognathic surgery procedures. This review was registered on http://www.crd.york.ac.uk/PROSPERO as CRD42013004711.

Short dental implants in reduced alveolar bone height: A review of the literature

Background The purpose of this study was to evaluate the use of short dental implants in distally reduced alveolar bone height. Material/Methods MedLine (PubMed and Ovid), ISI Web of Knowledge, and Cochrane databases were used for analysis. Searching was conducted using the search equation: ‘Dental Implants’ [Majr] AND (Short[TIAB] OR Shorter[TIAB]) AND (Implant[TIAB] OR Implants[TIAB]). Abstracts were screened by 2 independent reviewers. The articles included in the analysis were published in the English language and reported data on the use of implants with lengths below 10 mm in the posterior region with reduced alveolar bone height making the placement of longer implants impossible without additional surgical interventions. Articles concerning data on orthodontic implants and post-resection surgery reconstruction were excluded from analysis. Any disagreements between the 2 reviewers were resolved by a third reviewer. No time frame was used. Results Of the 791 articles initially found, automatic rejection of duplicates in the Endnotes X5 software resulted in 538 articles. After the selection of studies from databases, a bibliography of 32 eligible articles was searched for other publications. Through this method, 2 more studies were added. Conclusions The analysis of the results of different studies on the use of short dental implants showed that this treatment could be effective and comparable to the use of standard-length implants. This study revealed that rough-surfaced implants with lengths between 6–10 mm placed in the posterior mandible are the preferred solution. However, more detailed data will require additional prospective studies.

Clinical assessment of the safe use local anaesthesia with vasoconstrictor agents in cardiovascular compromised patients: A systematic review

Background The use of vasoconstrictor agents has many advantages, but its use has been limited due to a fear of systemic absorption and the induction of adverse effects in cardiac compromised patients. The aim of this study was to review the literature to assess any scientific basis for the limited use of dental anaesthesia with a vasoconstrictor agent in cardiovascular compromised patients. Material/Methods A comprehensive database search was executed with the use of Medline (PubMed), ISI Web of Science, and Cochrane. The inclusion criteria were: a clearly defined dose of vasoconstrictor agent and the testing of at least 1 parameter (pressure, heart rate, or saturation) or occurrence of at least 1 cardiac incident (complication). Results Among all complications, only 10 could be directly related to the use of local anaesthesia. It is noteworthy that 40% appeared after the administration of anaesthesia without vasoconstrictor agents. No severe adverse clinical effects were noted in the analysed studies. Conclusions The most frequent complications in cardiovascular compromised patients after dental local anaesthesia with a vasoconstrictor agent were disclosed in ECG arrhythmias. Most of these disclosed arrhythmias were clinically insignificant. The use of ≤4 ampules of lignocaine with epinephrine 1:100000 as a dental anaesthetic seems to be relatively safe for cardiovascular compromised patients.

Three-Dimensional Eyeball and Orbit Volume Modification After LeFort III Midface Distraction.

AbstractThe aim of our study was to evaluate orbital volume modification with LeFort III midface distraction in patients with craniosynostosis and its influence on eyeball volume and axial diameter modification. Orbital volume was assessed by the semiautomatic segmentation method based on deformable surface models and on 3-dimensional (3D) interaction with haptics. The eyeball volumes and diameters were automatically calculated after manual segmentation of computed tomographic scans with 3D slicer software. The mean, minimal, and maximal differences as well as the standard deviation and intraclass correlation coefficient (ICC) for intraobserver and interobserver measurements reliability were calculated. The Wilcoxon signed rank test was used to compare measured values before and after surgery. P < 0.05 was considered statistically significant. Intraobserver and interobserver ICC for haptic-aided semiautomatic orbital volume measurements were 0.98 and 0.99, respectively. The intraobserver and interobserver ICC values for manual segmentation of the eyeball volume were 0.87 and 0.86, respectively. The orbital volume increased significantly after surgery: 30.32% (mean, 5.96 mL) for the left orbit and 31.04% (mean, 6.31 mL) for the right orbit. The mean increase in eyeball volume was 12.3%. The mean increases in the eyeball axial dimensions were 7.3%, 9.3%, and 4.4% for the X-, Y-, and Z-axes, respectively. The Wilcoxon signed rank test showed that preoperative and postoperative eyeball volumes, as well as the diameters along the X- and Y-axes, were statistically significant. Midface distraction in patients with syndromic craniostenosis results in a significant increase (P < 0.05) in the orbit and eyeball volumes. The 2 methods (haptic-aided semiautomatic segmentation and manual 3D slicer segmentation) are reproducible techniques for orbit and eyeball volume measurements.

Effects of immunosuppressive treatment on protein expression in rat kidney

The structural proteins of renal tubular epithelial cells may become a target for the toxic metabolites of immunosuppressants. These metabolites can modify the properties of the proteins, thereby affecting cell function, which is a possible explanation for the mechanism of immunosuppressive agents’ toxicity. In our study, we evaluated the effect of two immunosuppressive strategies on protein expression in the kidneys of Wistar rats. Fragments of the rat kidneys were homogenized after cooling in liquid nitrogen and then dissolved in lysis buffer. The protein concentration in the samples was determined using a protein assay kit, and the proteins were separated by two-dimensional electrophoresis. The obtained gels were then stained with Coomassie Brilliant Blue, and their images were analyzed to evaluate differences in protein expression. Identification of selected proteins was then performed using mass spectrometry. We found that the immunosuppressive drugs used in popular regimens induce a series of changes in protein expression in target organs. The expression of proteins involved in drug, glucose, amino acid, and lipid metabolism was pronounced. However, to a lesser extent, we also observed changes in nuclear, structural, and transport proteins’ synthesis. Very slight differences were observed between the group receiving cyclosporine, mycophenolate mofetil, and glucocorticoids (CMG) and the control group. In contrast, compared to the control group, animals receiving tacrolimus, mycophenolate mofetil, and glucocorticoids (TMG) exhibited higher expression of proteins responsible for renal drug metabolism and lower expression levels of cytoplasmic actin and the major urinary protein. In the TMG group, we observed higher expression of proteins responsible for drug metabolism and a decrease in the expression of respiratory chain enzymes (thioredoxin-2) and markers of distal renal tubular damage (heart fatty acid-binding protein) compared to expression in the CMG group. The consequences of the reported changes in protein expression require further study.

Maxillary Sinus Septa Prevalence and Morphology: Computed Tomography Based Analysis

El objetivo de este estudio fue determinar la prevalencia, ubicacion y morfologia del septo del seno maxilar, y en particular de las formas orientadas sagitalmente, que no pueden ser visualizadas con el uso de equipos convencionales de Rayos X en dos dimensiones. De esta manera, se busca ofrecer informacion sobre el grupo potencial de pacientes, que seran sometidos a estudios de tomografia computarizada antes de la elevacion del seno maxilar. El analisis se baso en 216 imagenes de archivo de tomografia computarizada. El criterio de exclusion fue la presencia de cualquier sospecha de patologia en la region maxilar. La prevalencia de septos hallados en tomografia computarizada fue alta (49%) con una altura media de 5,44 mm. La incidencia de septos orientados sagitalmente, encontrados en estudios de Rayos X 2D fue del 10%, siendo la localizacion mas frecuente la region del segundo molar. De acuerdo a los resultados obtenidos y respetando los principios de seguridad radiologica, los autores sugieren que la ortopantomografia de rayos X puede ser un examen radiologico suficiente antes de comenzar el procedimiento quirurgico de implante en el area del seno maxilar.

Maxillary sinus septa: prevalence, morphology, diagnostics and implantological implications. Systematic review

Background: The purpose of this review is to indicate the prevalence of septa, illustrate the most adequate diagnostic method and further discuss pre-operative considerations and implantological implications. Materials and methods: On June 30th, 2013, a comprehensive database search was executed using PubMed (Medline) and Google Scholar. No time frames were applied. Only publications in English, Polish and German in peer-reviewed journals were considered. Results: The final number of articles was 55: 7 articles were found to describe the possible aetiology of sinus septa, 34 articles describing the prevalence, 21 including information on classification, 19 showed methods of diagnosis and 24 articles included practical information about the influence of the septa in pre- and implantation surgery. One article could be found in more than one category. Conclusions: Septa can be found in 9% to 70% patients (mean prevalence: about 36%) in every age group — young dentate patients as primary septa and old edentate or edentulous patients as primary or secondary septa more frequentin edentate or edentulous patients. When planning any surgical procedures, septa incidence should be taken into consideration. Precise information about the septa can be obtained from computed tomography (CT) or cone-beam CT. With development of the knowledge and surgical technique, septa appearance has simply become another option for treatment as any form of disadvantage.

Percutaneous Nephrolithotomy Using an Individual 3-Dimensionally Printed Surgical Guide

Percutaneous nephrolithotomy (PNL) is an endoscopic technique used for treating large stones, multiple stones, and staghorn calculi. Although minimally invasive, complication rate of PNL reaches 25%, and it is partially associated with needle puncture during nephrostomy tract preparation. Continuous improvement of armamentarium and imaging methods and the introduction of three-dimensional (3D) visualizations optimize the procedure; however, the rapid and precise establishment of the nephrostomy tract is still difficult. In the present short communication, we present the PNL procedure assisted by a personalized 3D-printed surgical guide (SG) to ensure fast and precise needle access to the renal collecting system. We also describe the workflow for SG preparation, which consists of CT image acquisition and data segmentation, planning a safe needle insertion path, SG designing, and guide manufacturing. With the growing market of low-cost 3D printers, the presented technique can shorten the PNL procedure time and decrease the complication rate associated with needle puncture in a cost-efficient manner.

Three-Dimensional Printing as an Interdisciplinary Communication Tool: Preparing for Removal of a Giant Renal Tumor and Atrium Neoplastic Mass.

Three-dimensional (3D) printing involves preparing 3D objects from a digital model. These models can be used to plan and practice surgery. We used 3D printing to plan for a rare complicated surgery involving the removal of a renal tumor and neoplastic mass, which reached the heart atrium. A printed kidney model was an essential element of communication for physicians with different specializations.

Effects of different etching modes on the nanoleakage of universal adhesives: A systematic review and meta-analysis

PURPOSE The aim of this systematic review was to evaluate how etching modes affect the nanoleakage of universal adhesive from in vitro studies. MATERIALS AND METHODS PubMed/MEDLINE, Web of Science, Scopus and Science Direct electronic databases were searched for in vitro studies that evaluated the nanoleakage of universal adhesives. A total of 511 (after duplicate removal) potentially relevant records were identified in the literature search. The titles and abstracts of the retrieved studies were screened by two independent researchers according to the main concept. Subsequently, the full text of potentially relevant studies was screened using the exclusion criteria. Thirteen studies were subjected to qualitative analysis, and 5 of them were selected for a detailed meta-analysis. RESULTS Seven universal adhesives were evaluated in this review. The meta-analysis demonstrated that the etch-and-rinse technique significantly reduced the nanoleakage of the Peak Universal and G-Bond Plus adhesives, whereas the self-etch mode reduced the nanoleakage of All-Bond Universal. In comparison, the etching technique did not significantly alter the nanoleakage of either Prime&Bond Elect or Scotchbond Universal which was characterized by the smallest nanoleakage. CONCLUSIONS Etching modes significantly, in various ways, influence the nanoleakage of universal adhesives. CLINICAL SIGNIFICANCE Contrary to the drive to simplify bonding technologies, an appreciation of their adhesive components and how these perform according to bonding technique could yield a knowledge-based practical approach that ultimately improves the longevity of direct composite restorations.