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Featured researches published by Tomohide Tanaka.


Journal of Liquid Chromatography & Related Technologies | 1979

The Determination of Optical Isomers of 2-[3-(2-Chloro-Penoxyphenyl)]-Propionic Acid in Rat Plasma by High Performance Liquid Chromatography

Tomozoh Tamegai; Tomohide Tanaka; Takeru Kaneko; Satoshi Ozaki; Masahiko Ohmae; Kiyoshi Kawabe

Abstract The optical isomers of dl-2-[3-(2-chlorophenoxy-phenyl)]-propionic acid in rat plasma is converted to the diastereomeric derivatives with (+)-2-aminobutane and then determined by high performance liquid chromatography using a Nucleosil NH2 (10 μm) column and cyclohexane-ethyl acetate (5:1) as a mobile phase. The time course of the optical isomers of this drug in rat plasma after oral administration was measured. The proposed method is specific and reproducible for the determination of the optical isomers of this drug.


Archive | 1996

Stable polymorphs of donepezil (1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine) hydrochloride and process for production

Akio Imai; Hideaki Watanabe; Takashi Kajima; Yasushi Ishihama; Akiyo Ohtsuka; Tomohide Tanaka


Archive | 1992

CELL DIFFERENTIATION INDUCING AGENT

Takashi Hibi; Shigemitsu Osawa; Tatsu Sakai; Kana Satou; Yoshio Tanabe; Tomohide Tanaka; 加名 佐藤; 重光 大沢; 孝 日比; 智英 田中; 義雄 田邊; 達 酒井


Chemical & Pharmaceutical Bulletin | 1990

Stability of a novel hexapeptide, (Me)Arg-Lys-Pro-Trp-tert-Leu-Leu-OEt, with neurotensin activity, in aqueous solution and in the solid state.

Tadakazu Tokumura; Tomohide Tanaka; Atsushi Sasaki; Yutaka Tsuchiya; Kouichi Abe; Ryoichi Machida


Archive | 1997

Polymorphic crystal of donepezil hydrochloride and its production

Akio Imai; Yasushi Ishihama; Takashi Kajima; Yukio Narabe; Akiyo Ootsuka; Tomohide Tanaka; Hideaki Watanabe; 昭生 今井; 昭代 大塚; 幸夫 奈良部; 隆 梶間; 英明 渡辺; 智英 田中; 泰 石濱


Archive | 1993

Skin whitening composition containing teprenone

Itaru Sakai; Kana Satoh; Tomohide Tanaka; Yutaka Morita; Takashi Hibi; Yoshio Tanabe; Shigemitsu Osawa; Yasushi c


Journal of Pharmaceutical Sciences | 1993

Pharmacokinetics of (Me)Arg-Lys-Pro-Trp-tert-Leu-Leu-OEt and (Me)Arg-Lys-Pro-Trp-tert-Leu-Leu Administered Intravenously to Beagle Dogs

Tadakazu Tokumura; Ryouichi Machida; Yutaka Tsuchiya; Atsushi Sasaki; Kouichi Abe; Tomohide Tanaka; Yasuharu Saeki


Archive | 2004

Polymorphic crystal of donepezil hydrochloride and manufacture method thereof

Akio Imai; Yasushi Ishihama; Takashi Kajima; Yukio Narabe; Akiyo Ootsuka; Tomohide Tanaka; Hideaki Watanabe; 昭生 今井; 昭代 大塚; 幸夫 奈良部; 隆 梶間; 英明 渡辺; 智英 田中; 泰 石濱


Archive | 1992

Cell differentiation promotor

Takashi Hibi; Yutaka Morita; Shigemitsu Osawa; Tatsu Sakai; Kana Satou; Yoshio Tanabe; Tomohide Tanaka; 加名 佐藤; 重光 大沢; 孝 日比; 豊 森田; 智英 田中; 義雄 田邊; 達 酒井


Archive | 2008

Polymorphic crystal of donepezil hydrochloride and process for producing the same

Akio Imai; Yasushi Ishihama; Takashi Kajima; Yukio Narabe; Akiyo Ootsuka; Tomohide Tanaka; Hideaki Watanabe; 昭生 今井; 昭代 大塚; 幸夫 奈良部; 隆 梶間; 英明 渡辺; 智英 田中; 泰 石濱

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