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Drug Development and Industrial Pharmacy | 1993

Effect of water-Insoluble Powder Addition on Physical Properties of Gelatin Gel

Kazuhisa Samura; Yoshiteru Kato; Yutaka Morita; Masao Kawamura; Noritoshi Koyama; Shigemitsu Osawa

AbstractWater-insoluble powder is often dispersed in shells of commercial soft capsules for various reasons, but little reports have been published about the effect of powder addition on the physical properties of the gelatin gel. Glass powder, titanium oxide, calcium carbonate and γ-orizanol were used as model of powder. Changes of Young modulus obtained from the tensile test showed that any powder addition to the gelatin sheet made the gelatin sheet hard not by the surface effect of powder but by the volumetric effect of it. In this test, any powders had no effect on the tensile strength of the gelatin sheet because there was little interaction between each powder and the gelatin gel in the break point. The limiting strain was decreased a little up to the specific amount of each powder and then beyond the specific amount that decreased steeply in the case of glass powder and γ-orizanol. There might be a suitable range of the amount of powder for the gelatin sheet to keep the plastic flow similar to the ...


Archive | 1992

CELL DIFFERENTIATION INDUCING AGENT

Takashi Hibi; Shigemitsu Osawa; Tatsu Sakai; Kana Satou; Yoshio Tanabe; Tomohide Tanaka; 加名 佐藤; 重光 大沢; 孝 日比; 智英 田中; 義雄 田邊; 達 酒井


Biological & Pharmaceutical Bulletin | 1996

Effects of Liposome Size on Penetration of dl-Tocopherol Acetate into Skin

Reiko Natsuki; Yutaka Morita; Shigemitsu Osawa; Yoshinori Takeda


Archive | 1989

Pharmaceutical preparation for percutaneous administration containing bunazosin or its salt

Mitsuhiro Yoshida; Hiroyuki Fujimori; Hidenori Asakawa; Masayoshi Kasai; Masanori Kayano; Shigemitsu Osawa


Archive | 1994

Pharmaceutical preparation for masking bitterness

Masao Kawamura; Katsuhiro Nakamura; Shigemitsu Osawa; Satoshi Sugawara; 雄啓 中村; 重光 大沢; 政男 河村; 智 菅原


Archive | 1991

Internal liquid agent prevented from nasty smell generation

Yasuo Iwaki; Shoji Kaneko; Noritoshi Koyama; Toshio Kurobe; Shigemitsu Osawa; Koichi Sakai; Takako Shinpo; 重光 大沢; 典利 小山; 康男 岩城; 太佳子 新保; 弘一 酒井; 彰治 金子; 俊夫 黒部


Archive | 1991

Soft capsule containing water-soluble agent

Yoshiteru Kato; Masao Kawamura; Noritoshi Koyama; Shigemitsu Osawa; 義輝 加藤; 重光 大沢; 典利 小山; 政男 河村


Archive | 1993

Skin whitening composition containing teprenone

Itaru Sakai; Kana Satoh; Tomohide Tanaka; Yutaka Morita; Takashi Hibi; Yoshio Tanabe; Shigemitsu Osawa; Yasushi c


Archive | 1989

Nasal inhalant cataplasm

Shoji Kaneko; Yutaka Morita; Shigemitsu Osawa; Akira Shiroishi; Satoru Yamagiwa


Archive | 1992

Cell differentiation promotor

Takashi Hibi; Yutaka Morita; Shigemitsu Osawa; Tatsu Sakai; Kana Satou; Yoshio Tanabe; Tomohide Tanaka; 加名 佐藤; 重光 大沢; 孝 日比; 豊 森田; 智英 田中; 義雄 田邊; 達 酒井

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