Tomohiko Matsuta

Phenolic compounds from the leaves of Psidium guajava II. Quercetin and its glycosides

0009-3130/12/4803-0477 2012 Springer Science+Business Media, Inc. 1) Faculty of Agriculture, Kagoshima University, 1-21-24 Korimoto, 890-0065, Kagoshima, Japan, e-mail: parkbj71@mail.goo.ne.jp; 2) Meikai University School of Dentistry, 1-1 Keyakidai, Sakado, 350-0283, Saitama, Japan; 3) Harunire Bio Laboratory Co., Ltd., 603-2 Hakuyo-cho, 090-0013, Kitami, Japan; 4) Dept. of Bio-Health Technology, Kangwon National University, 200-701, Chuncheon, Korea; 5) Korea National University of Agricultural & Fisheries, 445-893, Hwasung, Korea. Published in Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2012, pp. 429–431. Original article submitted February 1, 2011. Chemistry of Natural Compounds, Vol. 48, No. 3, July, 2012 [Russian original No. 3, May–June, 2012]

Functional Analysis of Natural Polyphenols and Saponins as Alternative Medicines

Hiroshi Sakagami1, Tatsuya Kushida2, Toru Makino3, Tsutomu Hatano4, Yoshiaki Shirataki5, Tomohiko Matsuta1, Yukiko Matsuo6 and Yoshihiro Mimaki6 1Meikai University School of Dentistry, Saitama, 2Non-Profit Organization Bio-Knowledge Bank, Tokyo, 3HumaLabo Co., Ltd., Tokyo, 4Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, 5Faculty of Pharmaceutical Sciences, Josai University, Saitama, 6Tokyo University of Pharmacy and Life Sciences, School of Pharmacy, Tokyo, Japan

Biological Activity of Cacao Husk and Mass Lignin-Carbohydrate Complexes

The reports of biological activity of lignin-carbohydrate complex (LCC) have been quite few, as compared with that of lower molecular weight polyphenols, possibly due to the structural complexity. Cacao mass and husk LCCs were completely solubilized and sterilized by autoclaving under mild alkaline condition, without losing their biological activities. They showed much higher anti-HIV activity, as compared with lower molecular weight polyphenols. They showed synergy with vitamin C in cytotoxicity induction and radical scavenging. They did not induce NO and cytokine production but enhanced the LPS-induced iNOS protein expression by mouse macrophages, suggesting several new biological activity of LCC distinct from LPS.

Functional Evaluation of Sasa Makino et Shibata Leaf Extract as Group III OTC Drug

Kampo Medicines, classified as Group II, are usually available as hot water extracts of more than two different plant species. Recently, the presentation of the detailed compositional analysis by HPLC has become mandatory for the publication of the biological activity of Kampo Medicines. However, we often experience the loss of biological activity of Kampo medicines during the purification steps, thus making it difficult to assign the active princi‐ ples. Herb extracts are classified into Group II and Group III. Three major products of bam‐