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Dive into the research topics where Tomoko Hanamizu is active.

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Featured researches published by Tomoko Hanamizu.


Journal of Bioscience and Bioengineering | 2009

Streptococcus thermophilus produces exopolysaccharides including hyaluronic acid

Naoki Izawa; Tomoko Hanamizu; Ryoko Iizuka; Toshiro Sone; Harumi Mizukoshi; Kazumasa Kimura; Katsuyoshi Chiba

Hyaluronic acid (HA) is an important material for medical, cosmetic and food applications. HA is obtained commercially from rooster combs and the fermentation of streptococci. However, the safety problems such as hyaluronidase or exotoxin contamination remain controversial. To reduce the risk of hyaluronidase or exotoxin contamination, we attempted to isolate strains of Streptococcus thermophilus with high productivity of useful exopolysaccharides (EPSs) including HA from traditional dairy food products. Forty-six S. thermophilus strains were isolated from dairy food products, and examined of their HA production using a HA binding protein method. According to the results, six S. thermophilus strains produced EPSs including HA. S. thermophilus YIT 2084 had a markedly high HA productivity (approximately 8 mg/l). We focused on the high-molecular-mass fraction of EPS (2000 kDa) from S. thermophilus YIT 2084. By using high-performance liquid chromatography, it was found that a high-molecular-mass fraction of EPS included N-acetylglucosamine (54.4%) and glucuronic acid (45.6%), which are components of HA. Furthermore, 13C-nuclear magnetic resonance spectroscopy showed that the spectra of the high-molecular-mass fraction corresponded well to those of commercial HA. Here, we described for the first time that S. thermophilus, which is a generally recognized safe bacterium, produces HA. The novel HA-producing bacterium S thermophilus YIT 2084 has great potential for applications in the medical, cosmetic and food fields, although its culture conditions remain to be improved.


Journal of Bioscience and Bioengineering | 2010

Effects of fermentation conditions and soybean peptide supplementation on hyaluronic acid production by Streptococcus thermophilus strain YIT 2084 in milk

Naoki Izawa; Tomoko Hanamizu; Toshiro Sone; Katsuyoshi Chiba

To increase the hyaluronic acid (HA) yield from Streptococcus thermophilus YIT 2084, fermentation conditions (pH, temperature, agitation, aeration) were optimized in milk-based medium, and the effects of supplemental soybean peptides, which have different molecular weight distributions, were determined. HA production was enhanced to approximately 100 mg/l at pH 6.8 and 33-40 degrees C. Agitation speed and aeration rate slightly affected HA production. Soybean peptides including those of high molecular weight (approximately 27 to 130 kDa) further increased HA production to 208 mg/l under the optimal condition (pH 6.8, 35 degrees C, 100 rpm), which was 20-fold greater than non-optimal condition. HA production was no longer related to the specific growth rate. The HA produced under the optimal condition included a large amount of high-molecular-weight fraction of 100 to 2000 kDa, compared with under the basal condition without optimization.


International Journal of Cosmetic Science | 1999

Moisturizing effect of vesicles formed from monoglycerides on human skin

Toshiro Sone; Tomoko Hanamizu; Minoru Ichioka; Teruo Yokokura; Satoshi Yoshikawa; Naomi Kondo-Yanai; Yoshio Hiraki; Kunio Esumi

The moisturizing effect of vesicles formed from monoglycerides on human skin was studied by measurement of conductance on and transepidermal waterloss from the skin surface. Although sonication of the monoglycerides in water with Ca2+ gave multilamellar vesicles, the lamellar structure of the vesicles disappeared during their storage without any other additive. With the addition of poly(vinylpyrrolidone) after the sonication, the stability of the vesicles increased and their lamellar structure was maintained for 3 months at 40°C. These vesicles led to a significantly higher water content of the stratum corneum of human skin compared with non‐lamellar monoglyceride, and consequently they improved rough human skin.


Colloids and Surfaces A: Physicochemical and Engineering Aspects | 1996

Effect of poly(vinylpyrrolidone) on the stability of vesicles formed using monoglyceride

Toshiro Sone; Tomoko Hanamizu; Minoru Ichioka; Teruo Yokokura; Satoshi Yoshikawa; Yoshio Hiraki; Keiko Ikeda; Kunio Esumi

Poly(vinylpyrrolidone) (PVP) stabilized the lamellar structure of vesicles formed using monopalmitin. The electron spin resonance spectrum of spin-labeled PVP suggested that monopalmitin was adsorbed on the vesicles and it formed loops or tails in the lamellar structure. The stabilizing effect of PVP was supposed to be dependent on the steric stabilization of the vesicles and prevention of fusion or aggregation of the vesicles.


Archive | 2001

Compositions for retarding skin aging

Katsuyoshi Chiba; Toshiro Sone; Kouji Miyazaki; Tomoko Hanamizu; Fukiko Nishisaka; Sachiko Matsumoto; Ritsuo Aiyama


International Journal of Cosmetic Science | 2005

Topical application of Bifidobacterium‐fermented soy milk extract containing genistein and daidzein improves rheological and physiological properties of skin

Kouji Miyazaki; Tomoko Hanamizu; Toshiro Sone; Katsuyoshi Chiba; Takashi Kinoshita; Satoshi Yoshikawa


Archive | 1991

Antiphlogistic agent and cosmetic containing the same

Tomoko Hanamizu; Minoru Ichioka; Masako Nakazawa; Toshiro Sone; Teruo Yokokura; 真子 中沢; 稔 市岡; 俊郎 曽根; 輝男 横倉; 智子 花水


Archive | 1999

Skin care preparations for external use

Minoru Ichioka; Toshiro Sone; Tomoko Hanamizu; Makoto Ohwaki; Katsuyoshi Chiba; Koji Miyazaki; Yoshio Kabushiki Kaisha Yakult Honsha Hiraki; Satoshi Kabushiki Kaisha Yakult Honsha Yoshikawa


Archive | 2001

Antioxidant and skin preparations for external use

Toshiro Sone; Katsuyoshi Chiba; Ryoko Izuka; Tomoko Hanamizu; Hirosi Kono; Masahiko Iha


Archive | 2000

SKIN CARE COMPOSITION FOR EXTERNAL USE AND METHOD OF PRODUCING THE SAME

Tomoko Hanamizu; Takashi Kinoshita; Koji Miyazaki; Naohito Saito; Satoshi Yoshikawa; 聡 吉川; 尚仁 斉藤; 智子 花水

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Kunio Esumi

Tokyo University of Science

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