Tomoya Nobuta

Molecular Iodine Catalyzed Cross-Dehydrogenative Coupling Reaction between Two sp3 C–H Bonds Using Hydrogen Peroxide

A useful method for molecular iodine catalyzed oxidative C-C bond formation between tertiary amines and a carbon nucleophile using hydrogen peroxide as the terminal oxidant is reported. This is the first report of a molecular iodine catalyzed cross-dehydrogenative coupling (CDC) reaction between two sp(3) C-H bonds.

Direct Aerobic Photo-Oxidative Synthesis of Aromatic Methyl Esters from Methyl Aromatics via Dimethyl Acetals

A useful method for facile synthesis of aromatic methyl esters from methyl aromatics via dimethyl acetals by aerobic photo-oxidation using inexpensive and easily handled CBr(4) as catalyst is reported. This is the first example for direct preparation of the corresponding aromatic methyl esters from methyl aromatics.

Molecular-iodine-catalyzed aerobic oxidative synthesis of β-hydroxy sulfones from alkenes

The synthesis of β-hydroxy sulfones from alkenes and sodium sulfinates under aerobic oxidative conditions was achieved in the presence of a catalytic amount of molecular iodine. Molecular oxygen in air serves as the terminal oxidant and the catalytic amount of molecular iodine acts as the sulfonyl radical initiator and peroxide reductant.

Facile aerobic photooxidation of methyl group in the aromatic nucleus in the presence of an organocatalyst under VIS irradiation

We report a useful method for a facile synthesis of carboxylic acids from methyl aromatics by aerobic photooxidation using VIS irradiation and easily handled 2-chloroanthraquinone as organic catalysts under mild conditions such as an air atmosphere and ambient pressure and temperature. This is a more environmentally benign oxidation than previous methods, which require drastic reaction conditions.

One-pot metal-free syntheses of acetophenones from styrenes through aerobic photo-oxidation and deiodination with iodine.

A one-pot synthetic protocol of acetophenones from styrenes with molecular oxygen, visible light, and molecular iodine is reported. This procedure involves aerobic photo-oxidation and deiodination in one pot and provides the first report of metal-free direct syntheses of acetophenones from styrenes.

Direct aerobic photo-oxidative syntheses of aromatic methyl esters from methyl aromatics using anthraquinone-2,3-dicarboxylic acid as organophotocatalyst

This paper reports a useful method for facile direct syntheses of aromatic methyl esters from methyl aromatics by aerobic photo-oxidation using anthraquinone-2,3-dicarboxylic acid as an organophotocatalyst.

Molecular-iodine-catalyzed aerobic photooxidative C–C bond formation between tertiary amines and carbon nucleophiles

This paper reports a useful method for molecular-iodine-catalyzed aerobic photooxidative C–C bond formation between tertiary amines and carbon nucleophiles. This reaction provides a practical method for C–C bond formation through the use of molecular iodine, harmless visible light irradiation, and molecular oxygen as the terminal oxidant.

Aerobic photooxidative direct asymmetric aldol reactions of benzyl alcohols using water as the solvent

We report an aerobic photooxidative direct asymmetric aldol reaction using water as the solvent. In this reaction, primary benzyl alcohols are oxidized into benzaldehydes under an oxygen atmosphere using anthraquinone-2-sodium sulfonate monohydrate as an organophotocatalyst. Stereoselective aldol reactions then proceed using a proline-type organocatalyst.

Aerobic photooxidative synthesis of 2-aryl-4-quinazolinones from aromatic aldehydes and aminobenzamide using catalytic amounts of molecular iodine

This study reports a safe, mild, and environmentally benign synthetic method toward 2-aryl-4-quinazolinones from aromatic aldehydes and aminobenzamides through a cyclization–oxidation sequence using a catalytic amount of iodine, which serves as both a Lewis acid and an oxidant, harmless visible light irradiation, and molecular oxygen as the terminal oxidant.