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Tomoyuki Asai

Asahi Glass Co.

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Publication

Featured researches published by Tomoyuki Asai.

Tetrahedron | 1995

SYNTHESIS OF 7-FLUORO-2,4-METHYLENE-17,20-DIMETHYLPROSTACYCLINS. NOVEL STABLE PROSTACYCLIN ANALOGS AS POTENT ANTI-ANGINAL AGENTS

Yasushi Matsumura; Toyomichi Shimada; Toshiaki Nakayama; Masahiro Urushihara; Tomoyuki Asai; Yoshitomi Morizawa; Arata Yasuda

Abstract Synthesis of new stable fluoroprostacyclins, 7-fluoro-2,4-methylene-17, 20-dimethylprostacyclins (1,2) with potent and long-lasting anti-anginal activities has been achieved. The cyclobutylene prostaglandin skeleton 10 was constructed efficiently according to three-component coupling reaction. Stereospecific fluorination of silyl ether 11 and subsequent cyclization of the fluoride 12 successfully provided the desired 7-fluoro-2,4-methylene-17,20-dimethylprostacyclin.

Tetrahedron Letters | 1995

Synthesis of new stable fluoroprostacyclin analogs with potent anti-anginal activity

Tomoyuki Asai; Yoshitomi Morizawa; Toyomichi Shimada; Toshiaki Nakayama; Masahiro Urushihara; Yasushi Matsumura; Arata Yasuda

Abstract Synthesis of new stable fluoroprostacyclins, 7-fluoro-2,4-methylene-17,20-dimethylprostacyclins ( 1, 2 ) with potent and long-lasting anti-anginal activities has been achieved via three-component coupling reaction and stereospecific fluorination.

Chemical & Pharmaceutical Bulletin | 1995

Novel fluoroprostacyclin analogs with modified cycloalkylenyl chains. Highly potent and orally active anti-anginal agents.

Yasushi Matsumura; Tomoyuki Asai; Toyomichi Shimada; Toshiaki Nakayama; Masahiro Urushihara; Yoshitomi Morizawa; Aarata Yasuda; Taku Yamamoto; Buichi Fujitani; Kanoo Hosoki

Bulletin of the Chemical Society of Japan | 1996

Study on Efficient Synthetic Routes for 7-Fluoroprostaglandin F2α and 7-Fluoro-17,20-dimethyl-2,4-methyleneprostacyclin

Yasushi Matsumura; Toyomichi Shimada; Shu-Zhong Wang; Tomoyuki Asai; Yoshitomi Morizawa; Arata Yasuda

Bulletin of the Chemical Society of Japan | 1983

Synthesis of Potential Antineoplastic Anthracenedione Derivatives. II. 1,2-Dihydroxy Derivatives

Katsumi Nakamura; Tomoyuki Asai; Tamio Hara; Naoki Minorikawa; Tetsuo Suami

Archive | 2001

Method for producing an optically active 1-substituted 2-propanol

Toshihiko Tohma; Tomoyuki Asai

Synlett | 1995

FACILE AND EFFICIENT SYNTHESIS OF FLUOROPROSTACYCLIN ANALOGS

Yasushi Matsumura; Shu-Zhong Wang; Tomoyuki Asai; Toyomichi Shimada; Yoshitomi Morizawa; Arata Yasuda

Archive | 1991

Prostaglandin I2 derivatives

Tomoyuki Asai; Yoshitomi Morizawa; Arata Yasuda; Taku Yamamoto; Buichi Fujitani; Kanoo Hosoki

Archive | 1991

Neue prostaglandin-i2-derivate. New prostaglandin i2 derivatives.

Tomoyuki Asai; Yoshitomi Morizawa; Arata Yasuda; Taku Yamamoto; Buichi Fujitani; Kanoo Hosoki

Archive | 1991

NOVEL PROSTAGLANDIN I2 DERIVATIVES

Tomoyuki Asai; Yoshitomi Morizawa; Arata Yasuda; Taku Yamamoto; Buichi Fujitani; Kanoo Hosoki

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Yoshitomi Morizawa

Asahi Glass Co.

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Arata Yasuda

Asahi Glass Co.

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Toyomichi Shimada

Asahi Glass Co.

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Yasushi Matsumura

Asahi Glass Co.

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Buichi Fujitani

Asahi Glass Co.

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Kanoo Hosoki

Asahi Glass Co.

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Taku Yamamoto

Kyoto Prefectural University of Medicine

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Masahiro Urushihara

Asahi Glass Co.

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Toshiaki Nakayama

Asahi Glass Co.

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Shu-Zhong Wang

Asahi Glass Co.

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