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Featured researches published by Toshihiro Nishimura.


Chemistry: A European Journal | 1999

Asymmetric Total Synthesis of Taxol\R

Teruaki Mukaiyama; Isamu Shiina; Hayato Iwadare; Masahiro Saitoh; Toshihiro Nishimura; Naoto Ohkawa; Hiroki Sakoh; Koji Nishimura; Yu-ichirou Tani; Masatoshi Hasegawa; Koji Yamada; Katsuyuki Saitoh

A new method for the total asymmetric synthesis of antitumor agent Taxol is described. Baccatin III, a complex carbon framework, is synthesized by way of B to BC to ABC ring construction. Further, a method of forming Taxol from baccatin III and a β-amino acid is also demonstrated.


Chemistry: A European Journal | 1999

Asymmetric Total Synthesis of TaxolR

Teruaki Mukaiyama; Isamu Shiina; Hayato Iwadare; Masahiro Saitoh; Toshihiro Nishimura; Naoto Ohkawa; Hiroki Sakoh; Koji Nishimura; Yu-ichirou Tani; Masatoshi Hasegawa; Koji Yamada; Katsuyuki Saitoh


Archive | 2003

NEW PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME AND APPLICATION THEREOF

Shinji Kikuchi; Yoshimitsu Komatsu; Harunobu Mukoyama; Satoko Nakayama; Toshihiro Nishimura; Hideki Onoda; Hiroaki Shiobara; 聡子 中山; 晴信 向山; 寛明 塩原; 秀樹 大野田; 良充 小松; 伸次 菊池; 俊洋 西村


Archive | 2003

NEW IMIDAZO[1,5-a]PYRAZINE DERIVATIVE, MEDICINE COMPOSITION CONTAINING THE SAME AND THEIR USE

Shinji Kikuchi; Yoshimitsu Komatsu; Harunobu Mukoyama; Satoko Nakayama; Toshihiro Nishimura; Hideki Onoda; 聡子 中山; 晴信 向山; 秀樹 大野田; 良充 小松; 伸次 菊池; 俊洋 西村


Chemical & Pharmaceutical Bulletin | 2001

The Practical Synthesis of (2S)-7-Methoxy-1, 2, 3, 4-tetrahydro-2-naphthylamine via Optical Resolution of 2-(3-Methoxybenzyl)succinic Acid

Takashi Yanagi; Ken Kikuchi; Hideki Takeuchi; Takehiro Ishikawa; Toshihiro Nishimura; Tetsuhide Kamijo; Iwao Yamamoto


Chemistry Letters | 1999

Asymmetric Borane Reduction of Prochiral Ketones Using Aluminum Triethoxide and Chiral Amino Alcohols

Takashi Yanagi; Ken Kikuchi; Hideki Takeuchi; Takehiro Ishikawa; Toshihiro Nishimura; Tetsuhide Kamijo


Chemical & Pharmaceutical Bulletin | 2003

Asymmetric Borane Reduction of Prochiral Ketone Using Chiral Bis(α, α-diphenyl-2-pyrrolidinemethanol) Carbonate

Takashi Yanagi; Ken Kikuchi; Hideki Takeuchi; Takehiro Ishikawa; Toshihiro Nishimura; Minoru Kubota; Iwao Yamamoto


Chemical & Pharmaceutical Bulletin | 2001

The practical synthesis of a uterine relaxant, bis(2-[[(2S)-2-([(2R)-2-hydroxy-2-[4-hydroxy-3-(2-hydroxyethyl)-phenyl]ethyl]amino)-1,2,3,4-tetrahydronaphthalen-7-yl]oxy]-N,N-dimethylacetamide) sulfate (KUR-1246).

Takashi Yanagi; Ken Kikuchi; Hideki Takeuchi; Takehiro Ishikawa; Toshihiro Nishimura; Iwao Yamamoto


Chemistry Letters | 1997

An Asymmetric Synthesis of the ABC Ring System of 8-Demethyltaxoids from Optically Active 8-Membered Ring Compound via Intramolecular Aldol and Pinacol Coupling Reactions

Isamu Shiina; Toshihiro Nishimura; Naoto Ohkawa; Hiroki Sakoh; Koji Nishimura; Katsuyuki Saitoh; Teruaki Mukaiyama


Chemistry Letters | 1995

An Asymmetric Synthesis of the Fully Functionalized AB Ring System of 12-Demethyltaxol via Successive Stereoselective Allylation and Intramolecular Aldol Reactions

Isamu Shiina; Hayato Iwadare; Masahiro Saitoh; Naoto Ohkawa; Toshihiro Nishimura; Teruaki Mukaiyama

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Isamu Shiina

Tokyo University of Science

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