Toshio Kadota

Superoxide dismutase with prolonged in vivo half-life inhibits intravascular hemolysis and renal injury in burned rats

Although superoxide radicals and related metabolites have been postulated to underlie the pathogenesis of burn injury, critical evidence supporting this hypothesis is lacking. To test whether superoxide radicals play critical roles in burn injury, the effect of a superoxide dismutase (SOD) derivative (SM-SOD) was tested on intravascular hemolysis and renal tubular injury in rats subjected to burn shock. Within 3 hours after a given full-thickness burn of approximately 24% of body surface area, plasma levels of lipid peroxides increased significantly with concomitant increase in intravascular hemolysis. Histological examination showed a marked deposition of hemoglobin-like casts in renal tubules of the burned rats. Intravenous administration of SM-SOD (10 mg/kg) 30 minutes before the burn injury significantly inhibited the increase of plasma lipid peroxides and the occurrence of intravascular hemolysis. SM-SOD also inhibited the deposition of casts in renal tubules. These results indicate that superoxide radicals play critical roles in the pathogenesis of intravascular hemolysis and renal damage induced by burn injury.

Direct evidence for the occurrence of superoxide radicals in the small intestine of the burned rat

To determine if superoxide radicals (O2-) and related metabolites are generated in extradermal tissues of burned animals, 2-methyl-6-[p-methoxyphenyl]-3,7-dihydroimidazol [1,2-å]pyrazin-3-one (MCLA) was infused intravenously into rats, and change in the chemiluminescence (CL) intensity of the small intestine was determined by using a sensitive photodetector. When animals were challenged with burn stress of 40% total body surface area (TBSA), the CL intensity of the intestine gradually increased, reaching a maximum within 1 hour and remaining elevated for up to 3 hours. Pretreatment of animals with a long-acting superoxide dismutase (SOD) derivative (SM-SOD) significantly inhibited the increase in CL intensity. Administration of SM-SOD immediately after inducing burn injury also significantly inhibited the increase in CL. These results suggest that superoxide radicals are generated in extradermal tissues, such as the small intestine, in the early stage after burn injury.

GASTRIC CARCIONMA WITH SITUS INVERSUS VISCERUM TOTALIS REPORT OF A CASE

内臓逆位症は5,000人から10,000人に1人の割にみられるまれな疾患であるが, これに胃癌を合併した症例はわが国で21例と少ない.われわれは全内臓逆位症に合併した進行胃癌の1例を経験したので若干の文献的考察を加えて報告する.症例は41歳女性.主訴は心窩部痛および体重減少で, 入院後右胸心, 内臓逆位症に加えて前庭部中心の進行胃癌であることが判り, 胃亜全摘, R3廓清, 横行結腸合併切除さらにBI吻合を施行した.P1H0N3S3のStage IVで非治癒切除ではあったが, 術後経過は良好で3週間後に退院した.1年以上経った現在も元気に会社勤務に復している.