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Featured researches published by Toshio Kawamoto.


Drug Investigation | 1990

Probucol Promotes Hepatic Uptake of High Density Lipoprotein in Rats

Koki Takata; Itaru Horiuchi; Makato Okahashi; Hironori Tokumo; Kazunori Koide; Yasuhiko Hirata; Goro Kajiyama; Toshio Kawamoto

SummaryProbucol significantly reduced high density lipoprotein (HDL)-cholesterol and apolipoprotein AI in rats. Hepatic uptake of radiolabelled human HDL3 increased significantly in vivo and in the isolated perfused rat liver preparation. In vivo, uptake of HDL3 by the adrenal glands also increased significantly. Hepatic cholesterol content in probucol-treated rats tended to increase, whereas newly synthesised cholesterol decreased significantly. The results of the present study suggest that enhanced uptake of HDL is one of the mechanisms of lowering serum HDL with probucol treatment.


Hiroshima journal of medical sciences | 1980

Lipid metabolism in the development of cholesterol gallstones in hamsters. I. Study on the relationship between serum and biliary lipids.

Goro Kajiyama; Kubota S; Hiroshi Sasaki; Toshio Kawamoto; Akima Miyoshi


Hiroshima journal of medical sciences | 1981

THE INFLUENCE OF DIETARY CHOLESTEROL ON THE LITHOGENESITY OF BILE IN RATS TREATED WITH CLOFIBRA TE (II)

Toshio Kawamoto; Goro Kajiyama; Akira Maruhashi; Toshiyuki Mizuno; Yamada K; Masamichi Fujiyama; Akima Miyoshi


Hiroshima journal of medical sciences | 1981

THE EFFECT OF PANTETHINE, A PRECURSOR OF COENZYME A, ON BILE ACIDS AND LIPIDS IN RATS FED WITH A CHOLESTEROL DIET

Goro Kajiyama; Toshio Kawamoto; Choho Fukuhara; Itaru Horiuchi; Masahiro Nakagawa; Akima Miyoshi


Hiroshima journal of medical sciences | 1979

Change in lipid composition of bile with age in normal subjects and patients with gallstones.

Masamichi Fujiyama; Goro Kajiyama; Akira Maruhashi; Toshiyuki Mizuno; Yamada K; Toshio Kawamoto; Kubota S; Sasaki H; Ken Oyamada; Seiji Nakao; Akima Miyoshi


Hiroshima journal of medical sciences | 1991

Analyses of Survival Rate of Unresectable Pancreatic Adenocarcinoma in Aspect of Data Analyses

Masahiro Kawanishi; Atsuko Nakamoto; Masaki Ito; Masataka Hiraoka; Goro Kajiyama; Hiroyasu Yamada; Susumu Fujita; Toshio Kawamoto; Hiroshi Kawamura; Hiroshi Sasaki; Sukeyoshi Okamoto


The journal of Japan Atherosclerosis Society | 1986

HDL 3 Specific Binding to Rat Liver Plasma Membrane

Koki Takata; Toshio Kawamoto; Goro Kajiyama


The journal of Japan Atherosclerosis Society | 1986

Serum Squalene in Patients with Hyperlipoproteinemia

Shoji Nishimura; Toshio Kawamoto; Itaru Horiuchi; Koki Takata; Makoto Okahashi; Susumu Tazuma; Hironori Tokumo; Yoko Nomura; Toshihito Hiraoka; Goro Kajiyama


The journal of Japan Atherosclerosis Society | 1985

The Effect of β Sitosterol on Lipids and Apolipoproteins

Masami Ohki; Toshio Kawamoto; Itaru Horiuchi; Fumiaki Hind; Makoto Okahashi; Susumu Tazuma; Hironori Tokumo; Yoko Nomura; Toshihito Hiraoka; Tokuo Tsubokura; Goro Kajiyama


The journal of Japan Atherosclerosis Society | 1984

Effect of Probucol on Biliary Lipids and Fecal Sterol in Hyperlipoproteinemic Patients

Itaru Horiuchi; Takashi Nakagawa; Fumiaki Hino; Shoji Nishimura; Makoto Okahashi; Toshio Kawamoto; Goro Kajiyama

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Hiroshi Sasaki

Memorial Hospital of South Bend

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