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Featured researches published by Toshiyuki Kameyama.


Tetrahedron Letters | 1998

A new non-protein enediyne antibiotic N1999A2: Unique enediyne chromophore similar to neocarzinostatin and DNA cleavage feature

Toshihiko Ando; Makoto Ishii; Takayuki Kajiura; Toshiyuki Kameyama; Kiyoshi Miwa; Yukio Sugiura

Abstract The present NMR and X-ray structural studies demonstrated that the new antibiotic N1999A2 isolated from the broth filtrate of Streptomyces sp. AJ9493, possesses a novel 9-membered ring enediyne chromophore similar to neocarzinostatin, but is not chromoprotein. Of special interest is the fact that stable N1999A2 exists as enediyne chromophore alone as well as dynemicin A, esperamicin A 1 and calicheamicin γ 1 . The major difference between N1999A2 and neocarzinostatin chromophore is lack of the amino sugar in N1999A2. The antibiotic N1999A2 revealed more random DNA cutting profile than neocarzinostatin chromophore.


The Journal of Antibiotics | 1987

Bisucaberin, a new siderophore, sensitizing tumor cells to macrophage-mediated cytolysis. II: Physico-chemical properties and structure determination

Atsushi Takahashi; Hikaru Nakamura; Toshiyuki Kameyama; Shogo Kurasawa; Hiroshi Naganawa; Yoshiro Okami; Tomio Takeuchi; Hamao Umezawa; Yoichi Iitaka


The Journal of Antibiotics | 1987

Bisucaberin, a new siderophore, sensitizing tumor cells to macrophage-mediated cytolysis. I. Taxonomy of the producing organism, isolation and biological properties

Toshiyuki Kameyama; Atsushi Takahashi; Shogo Kurasawa; Masaaki Ishizuka; Yoshiro Okami; Tomio Takeuchi; Hamao Umezawa


The Journal of Antibiotics | 2001

New cyclic depsipeptide antibiotics, clavariopsins A and B, produced by an aquatic hyphomycetes, Clavariopsis aquatica. 2. Structure analysis.

Yoshihiro Suzuki; Makoto Ojika; Youji Sakagami; Kenichi Kaida; Ryosuke Fudou; Toshiyuki Kameyama


The Journal of Antibiotics | 2001

New Cyclic Depsipeptide Antibiotics, Clavariopsins A and B, Produced by an Aquatic Hyphomycetes, Clavariopsis aquatica

Yoshihiro Suzuki; Makoto Ojika; Youji Sakagami; Kenichi Kaida; Ryosuke Fudou; Toshiyuki Kameyama


The Journal of Antibiotics | 2001

New cyclic depsipeptide antibiotics, clavariopsins A and B, produced by an aquatic hyphomycetes, Clavariopsis aquatica. 1. Taxonomy, fermentation, isolation, and biological properties

Kenichi Kaida; Ryosuke Fudou; Toshiyuki Kameyama; Keisuke Tubaki; Yoshihiro Suzuki; Makoto Ojika; Youji Sakagami


The Journal of Antibiotics | 1993

Anisomycin and new congeners active against human tumor cell lines.

Yoshiko Hosoya; Toshiyuki Kameyama; Hiroshi Naganawa; Yoshiro Okami; Tomio Takeuchi


Bioscience, Biotechnology, and Biochemistry | 1997

Isolation of isoeugenitin as a fruiting body inducer for Stigmatella aurantiaca from a soil fungus Papulaspora sp.

Ryosuke Fudo; Toshihiko Ando; Seiichi Sato; Toshiyuki Kameyama; Shigeru Yamanaka


The Journal of Antibiotics | 1988

Thrazarine, a new antitumor antibiotic. II. Physico-chemical properties and structure determination.

Atsushi Takahashi; Hikaru Nakamura; Daishiro Ikeda; Hiroshi Naganawa; Toshiyuki Kameyama; Shogo Kurasawa; Yoshiro Okami; Tomio Takeuchi; Yoichi Iitaka


The Journal of Antibiotics | 1997

F390B and C, New Antitumor Dihydroxanthone Derivatives Isolated from Penicillium sp.

Seiichi Sato; Ryusuke Nakagawa; Ryosuke Fudo; Yumiko Fukuda; Toshihiko Yoshimura; Kenichi Kaida; Toshihiko Ando; Toshiyuki Kameyama; Takashi Tsuji

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Yoshiro Okami

Osaka University of Pharmaceutical Sciences

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