Toshiyuki Negoro
Dainippon Sumitomo Pharma Co., Ltd.
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Publication
Featured researches published by Toshiyuki Negoro.
Bioorganic & Medicinal Chemistry Letters | 2014
Futoshi Hasegawa; Kazumi Niidome; Chiaki Migihashi; Makoto Murata; Toshiyuki Negoro; Takafumi Matsumoto; Kaori Kato; Akihito Fujii
Furan-2-carbohydrazides were found as orally active glucagon receptor antagonists. Starting from the hit compound 5, we successfully determined the structure activity relationships of a series of derivatives obtained by modifying the acidity of the phenol. We identified the ortho-nitrophenol as a good scaffold for glucagon receptor inhibitory activity. Our efforts have led to the discovery of compound 7l as a potent glucagon receptor antagonist with good bioavailability and satisfactory long half-life.
Journal of Medicinal Chemistry | 1998
Toshiyuki Negoro; Makoto Murata; Shozo Ueda; Buichi Fujitani; Yoshiyuki Ono; Akemi Kuromiya; Masanobu Komiya; Kenji Suzuki; Jun-Ichi Matsumoto
Biochemical Pharmacology | 2006
Masuo Kurono; Akihito Fujii; Makoto Murata; Buichi Fujitani; Toshiyuki Negoro
Archive | 2003
Akihito Fujii; Toshiyuki Negoro; Chiaki Migihashi; Makoto Murata; Keiji Nakamura; Takashi Nukuda; Takafumi Matsumoto; Kiyomi Imano
Archive | 1992
Buichi Fujitani; Makoto Murata; Toshiyuki Negoro; Yoshiyuki Ono; Shozo Ueda; 昇三 上田; 善幸 小野; 誠 村田; 利行 根来; 武一 藤谷
Archive | 1992
Buichi Fujitani; Makoto Murata; Toshiyuki Negoro; Yoshiyuki Ono; Shozo Ueda; 昇三 上田; 善幸 小野; 誠 村田; 利行 根来; 武一 藤谷
Archive | 1992
Toshiyuki Negoro; Makoto Murata; Shozo Ueda; Buichi Fujitani; Yoshiyuki Ono
Archive | 2007
Daisuke Tanaka; Toshiyuki Negoro
Archive | 2011
Daisuke Tanaka; Toshiyuki Negoro
Archive | 2007
Daisuke Tanaka; Toshiyuki Negoro