Network


Latest external collaboration on country level. Dive into details by clicking on the dots.

Hotspot


Dive into the research topics where Toshiyuki Negoro is active.

Publication


Featured researches published by Toshiyuki Negoro.


Bioorganic & Medicinal Chemistry Letters | 2014

Discovery of furan-2-carbohydrazides as orally active glucagon receptor antagonists

Futoshi Hasegawa; Kazumi Niidome; Chiaki Migihashi; Makoto Murata; Toshiyuki Negoro; Takafumi Matsumoto; Kaori Kato; Akihito Fujii

Furan-2-carbohydrazides were found as orally active glucagon receptor antagonists. Starting from the hit compound 5, we successfully determined the structure activity relationships of a series of derivatives obtained by modifying the acidity of the phenol. We identified the ortho-nitrophenol as a good scaffold for glucagon receptor inhibitory activity. Our efforts have led to the discovery of compound 7l as a potent glucagon receptor antagonist with good bioavailability and satisfactory long half-life.


Journal of Medicinal Chemistry | 1998

Novel, highly potent aldose reductase inhibitors: (R)-(-)-2-(4-bromo-2-fluorobenzyl)-1,2,3,4- tetrahydropyrrolo[1,2-a]pyrazine -4-spiro-3'-pyrrolidine-1,2',3,5'-tetrone (AS-3201) and its congeners.

Toshiyuki Negoro; Makoto Murata; Shozo Ueda; Buichi Fujitani; Yoshiyuki Ono; Akemi Kuromiya; Masanobu Komiya; Kenji Suzuki; Jun-Ichi Matsumoto


Biochemical Pharmacology | 2006

Stereospecific recognition of a spirosuccinimide type aldose reductase inhibitor (AS-3201) by plasma proteins: A significant role of specific binding by serum albumin in the improved potency and stability

Masuo Kurono; Akihito Fujii; Makoto Murata; Buichi Fujitani; Toshiyuki Negoro


Archive | 2003

2-Furancarboxylic acid hydrazides and pharmaceutical compositions containing the same

Akihito Fujii; Toshiyuki Negoro; Chiaki Migihashi; Makoto Murata; Keiji Nakamura; Takashi Nukuda; Takafumi Matsumoto; Kiyomi Imano


Archive | 1992

Tetrahydropyrrolo(1,2-a)pyrazine-4-spiro-3'-pyrrolidine derivative and diabetic complication therapeutic agent with the same as active ingredient

Buichi Fujitani; Makoto Murata; Toshiyuki Negoro; Yoshiyuki Ono; Shozo Ueda; 昇三 上田; 善幸 小野; 誠 村田; 利行 根来; 武一 藤谷


Archive | 1992

Succinic acid imide derivative

Buichi Fujitani; Makoto Murata; Toshiyuki Negoro; Yoshiyuki Ono; Shozo Ueda; 昇三 上田; 善幸 小野; 誠 村田; 利行 根来; 武一 藤谷


Archive | 1992

Tetrahydropyrrolo[1,2-a]pyrazine-4-spiro-3'-pyrrolidine derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same

Toshiyuki Negoro; Makoto Murata; Shozo Ueda; Buichi Fujitani; Yoshiyuki Ono


Archive | 2007

Optically active 3-amino-2,5-dioxopyrrolidine-3-carboxylate, process for production of the compound, and use of the compound

Daisuke Tanaka; Toshiyuki Negoro


Archive | 2011

Process for preparing (3R)-2′-(4-bromo-2-fluorobenzyl)spiro-[pyrrolidine-3,4′(1′H)-pyrrolo[1,2-A]pyrazine]-1′,2,3′,5(2H′)-tetraone

Daisuke Tanaka; Toshiyuki Negoro


Archive | 2007

3-amino-2,5-dioxopyrrolidine-3-carboxylate optiquement actif, procédé de production du composé, et utilisation du composé

Daisuke Tanaka; Toshiyuki Negoro

Collaboration


Dive into the Toshiyuki Negoro's collaboration.

Top Co-Authors

Avatar

Makoto Murata

Dainippon Sumitomo Pharma Co.

View shared research outputs
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar

Akihito Fujii

Dainippon Sumitomo Pharma Co.

View shared research outputs
Top Co-Authors

Avatar

Chiaki Migihashi

Dainippon Sumitomo Pharma Co.

View shared research outputs
Top Co-Authors

Avatar

Daisuke Tanaka

Dainippon Sumitomo Pharma Co.

View shared research outputs
Top Co-Authors

Avatar

Takafumi Matsumoto

Dainippon Sumitomo Pharma Co.

View shared research outputs
Top Co-Authors

Avatar

Akemi Kuromiya

Dainippon Sumitomo Pharma Co.

View shared research outputs
Top Co-Authors

Avatar

Futoshi Hasegawa

Dainippon Sumitomo Pharma Co.

View shared research outputs
Top Co-Authors

Avatar

Kaori Kato

Dainippon Sumitomo Pharma Co.

View shared research outputs
Researchain Logo
Decentralizing Knowledge