Tsunesuke Kajimoto

Organic syntheses by means of noble metal compounds : XLI. Reaction of isocyanide with π-allylpalladium chloride

Abstract The treatment of cyclohexyl isocyanide with π-allylpalladium chloride in benzene at room temperature gave di-μ-chloro-bis[1-(cyclohexylimino)-3-butenyl]-bis(cyclohexylisocyanide)dipalladium by the insertion reaction. The progress of the insertion reaction was followed by NMR spectroscopy. The ethanolysis of the complex gave ethyl N-cyclohexyl-3-butenimidate.

Feline interferon-ω treatment on canine parvovirus infection

Recombinant feline interferon-ω preparation (rFeIFN-ω, trade name: INTERCAT) showed good clinical efficacy on canine parvovirus infection both in an experimental trial with beagles, and in field trials.

Organic Synthesis by Means of Metal Complexes. X1Copper Catalyzed Oxidation of o-Phenylenediamine to Mucononitrile

Abstract This paper describes a simple stereospecific synthesis of cis,cis-mucononitrile and its derivatives in hig hyields. The procedure is based on the oxidation of o-phenylenediamine derivatives with molecular oxygen catalyzed by cuprous salts. Oxidative coupling of aniline with molecular oxygen catalyzed by cuprous chloride gives azobenzene2. Also it is known that o-phenylenediamine (PDA) is oxidized in the presence of ferric3, Cobaltous4, and cupric chlorides5to afford 2,3-diaminophenazine or 2-amino-3oxophenazine. The formation of a metal nitrogen bonded intermediate, followed by intermolecular reaction was postulated in these oxidation reactions.6,7.Mechanistic consideration of these reactions leads us to expect that the oxidation of PDA with molecular oxygen under selected conditions should proceed intramolecularly with ring claevage to give mocononitrile(MNL). PDA is converted into MNL by using stoichimetricamount of nickel peroxide8or lead terraacetate9, but the yields are low. We now wish to r...

Crystal structure of μ-chloro-chloro-di-π-allyl (cyclohexanone oxime) dipalladium

Abstract The crystal structure of μ-chloro-chloro-di-π-allyl(cyclohexanone oxime)dipalladium, [Pd(π-C 3 H 5 )Cl] 2 C 6 H 10 NOH, has been determined from three-dimensional X-ray diffraction data collected on a single crystal diffractometer with Mo- K α radiation. The crystals belong to the triclinic space group P 1 ( C 1 i ), with cell parameters: a = 8.004±0.01 A, b = 14.47±0.01 A, c = 7.88±0.02 A, α = 95.1±0.1°, β = 90.3±0.2°, and − = 113.1±0.1°. The unit cell contains two molecules of the complex. The complex has a binuclear structure of the two palladium atoms, one coordinates to a π-allyl group and two chlorine atoms in a square-planar configuration. The other palladium atom coordinates to one chlorine atom, a π-allyl group and the nitrogen atom of the oxime, also with a square-planar geometry. The structure may be derived from that of bis(π-allylpalladium chloride) by rupture of the bond between the palladium and one of the bridge chlorine atoms, coordination of the nitrogen of the oxime to the palladium and formation by the terminal chlorine atom of a hydrogen bond with the hydroxyl group of the oxime. The orientation of the π-allyl groups with respect to the palladium atoms is similar to those found in other π-allyl complexes.