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Dive into the research topics where Ubasawa Masaru is active.

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Biochemical Pharmacology | 1993

Effect of human serum on the in vitro anti-HIV-1 activity of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) derivatives as related to their lipophilicity and serum protein binding.

Baba Masanori; Yuasa Satoshi; Niwa Takuro; Yamamoto Minako; Yabuuchi Shingo; Takashima Hideaki; Ubasawa Masaru; Tanaka Hiromichi; Miyasaka Tadashi; Richard T. Walker; Jan Balzarini; Erik De Clercq; Shigeta Shiro

Several derivatives of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) were examined for their inhibitory effects on the replication of human immunodeficiency virus type 1 (HIV-1) in MT-4 cells in the presence of various concentrations (10-50%) of human serum (HS). Although all HEPT derivatives proved to be highly potent inhibitors of HIV-1 in the presence of 10% fetal bovine serum, some of them were less inhibitory to HIV-1 replication in the presence of HS. The HEPT derivatives were found to be highly bound to HS proteins. Both the anti-HIV-1 activity and HS protein binding of the compounds appeared to be related to their lipophilicity.


Archive | 1995

PHOSPHONATONUCLEOTIDE ESTER DERIVATIVE

Takashima Hideaki; Sekiya Koichi; Inoue Naoko; Ubasawa Masaru; Yabuuchi Shingo


Archive | 2004

CRYSTAL OF 2-AMINO-6-(4-METHOXYPHENYLTHIO)-9-(2-(PHOSPHONOMETHOXY)ETHYL)PURINE BIS(2,2,2-TRIFLUOROETHYL) ESTER

Yoshizawa Katsuyoshi; Yamada Hiroyuki; Masunaga Toshio; Inokawa Harumoto; Sekiya Koichi; Shirasaka Tadashi; Ubasawa Masaru


Archive | 1993

PRODUCTION OF ACYCLONUCLEOSIDE DERIVATIVE

Ubasawa Masaru; Takashima Hideaki; Sekiya Koichi


Archive | 1991

PYRIMIDINE NUCLEOSIDE DERIVATIVE AND ANTIVIRAL AGENT WITH THE SAME AS ACTIVE INGREDIENT

Miyasaka Sada; Tanaka Hiromichi; Eritsuku Deezeree Arisu De Kur; Baba Masanori; Richiyaado Toomasu Uookaa; Ubasawa Masaru


Archive | 2002

6-substituerede acyclopyrimidin-nucleosid-derivater og antivirale midler, der indeholder disse derivater som aktive ingredienser

Baba Masanori; Tanaka Hiromichi; Ubasawa Masaru; Walker Richard Thomas; Miyasaka Tadashi; De Clercq Erik Desire Alice; Masanori Baba


Archive | 2001

Phosphonat-nukleotid-forbindelser

Ubasawa Masaru; Sekiya Kouichi; Takashima Hideaki; Ueda Naoko; Yuasa Satoshi; Kamiya Naohiro


Archive | 2001

COMPUESTOS NUCLEOTIDICO DE FOSFONATO.

Ubasawa Masaru; Sekiya Kouichi; Takashima Hideaki; Ueda Naoko; Yuasa Satoshi; Kamiya Naohiro


Archive | 2000

6-substituerede acyclopyrimiddinnukleosidderivater og antiviralt middel indeholdende disse som aktiv bestanddel

Walker Richard Thomas; Miyasaka Tadashi; Tanaka Hiromichi; De Clercq Erik Desire Alice; Baba Masanori; Ubasawa Masaru


Archive | 1999

DERIVADOS DE NUCLEOSIDOS DE ACICLOPIRIMIDINA 6-SUSTITUIDOS Y AGENTE ANTIVIRICO QUE LOS CONTIENE COMO SU INGREDIENTE ACTIVO.

Miyasaka Tadashi; Tanaka Hiromichi; De Clercq Erik Desire Alice; Baba Masanori; Walker Richard Thomas; Ubasawa Masaru

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Baba Masanori

Mitsubishi Chemical Corporation

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Walker Richard Thomas

Mitsubishi Chemical Corporation

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Kamiya Naohiro

Mitsubishi Chemical Corporation

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Sekiya Kouichi

Mitsubishi Chemical Corporation

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Ueda Naoko

Mitsubishi Chemical Corporation

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