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Dive into the research topics where Upendra K. Sharma is active.

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Featured researches published by Upendra K. Sharma.


Chemistry: A European Journal | 2015

Pd-Catalyzed Csp2H Functionalization of Heteroarenes via Isocyanide Insertion: Concise Synthesis of Di-(Hetero)Aryl Ketones and Di-(Hetero)Aryl Alkylamines

Upendra K. Sharma; Nandini Sharma; Jun Xu; Gonghua Song; Erik V. Van der Eycken

We report herein an efficient Pd-catalyzed direct C-H bond functionalization of heteroarenes via an isocyanide insertion strategy for the synthesis of di-(hetero)aryl ketones and di-(hetero)aryl alkylamines. The methodology involves a three component reaction between an azole, a haloarene and an isocyanide resulting in the formation of an imine, which in turn is either hydrolyzed or reduced to get the desired product.


Chemistry: A European Journal | 2016

Domino Carbopalladation/C-H Functionalization Sequence: An Expedient Synthesis of Bis-Heteroaryls through Transient Alkyl/Vinyl-Palladium Species Capture

Upendra K. Sharma; Nandini Sharma; Yogesh Kumar; Brajendra K. Singh; Erik V. Van der Eycken

A microwave-assisted highly efficient intermolecular domino carbopalladation/C-H functionalization sequence has been developed to access bis-heteroaryl frameworks in a single operation. The reaction involves carbopalladation of the halogenated acrylamides or phenylpropiolamides by the Pd(0) catalysis, followed by the direct (hetero)arylation to give products with good to excellent yields. The synthetic utility of this method was also extended towards the application of the Ugi-adduct as the starting material.


Chemistry: A European Journal | 2016

Microwave-Assisted Copper-Catalyzed Oxidative Cyclization of Acrylamides with Non-Activated Ketones.

Yaping Zhao; Nandini Sharma; Upendra K. Sharma; Zhenghua Li; Gonghua Song; Erik V. Van der Eycken

An operationally simple and efficient microwave-assisted protocol for the oxidative cyclization of acrylamide derivatives with non-activated ketones to generate 3,3-disubstituted oxindoles is described. The reaction proceeds by a copper-catalyzed tandem radical addition/cyclization strategy and tolerates a series of functional groups with moderate to excellent yields.


Angewandte Chemie | 2017

A Lewis Base Catalysis Approach for the Photoredox Activation of Boronic Acids and Esters

Fabio Lima; Upendra K. Sharma; Lars Grunenberg; Debasmita Saha; Sandra Johannsen; Joerg Sedelmeier; Erik V. Van der Eycken; Steven V. Ley

Abstract We report herein the use of a dual catalytic system comprising a Lewis base catalyst such as quinuclidin‐3‐ol or 4‐dimethylaminopyridine and a photoredox catalyst to generate carbon radicals from either boronic acids or esters. This system enabled a wide range of alkyl boronic esters and aryl or alkyl boronic acids to react with electron‐deficient olefins via radical addition to efficiently form C−C coupled products in a redox‐neutral fashion. The Lewis base catalyst was shown to form a redox‐active complex with either the boronic esters or the trimeric form of the boronic acids (boroxines) in solution.


RSC Advances | 2017

Direct C-2 acylation of indoles with toluene derivatives via Pd(II)-catalyzed C–H activation

Yaping Zhao; Upendra K. Sharma; Felix Schrӧder; Nandini Sharma; Gonghua Song; Erik V. Van der Eycken

A simple and efficient Pd-catalyzed method for the C2-acylation of indoles is described. Less toxic, stable, and commercially available toluene derivatives were used as acyl sources, with tert-butylhydroperoxide (TBHP) as oxidant and pivalic acid as additive, providing moderate to good yields.


Drug Discovery Today: Technologies | 2018

Gold-catalyzed post-MCR transformations towards complex (poly)heterocycles

Upendra K. Sharma; Guilong Tian; Leonid G. Voskressensky; Erik V. Van der Eycken

Post multicomponent reaction (MCR) transformations are one of the most successful methods leading to high structural diversity and molecular complexity. A well-known MCR, the Ugi reaction typically affords a linear peptide backbone, enabling post-Ugi transformations as an elegant solution to rigidify the Ugi adduct into more drug-like species. Not surprisingly, the development of such transformations leading to new structural frameworks has expanded rapidly over the last few years. These reactions have reached an impressive level of performance and versatility, particularly in amalgamation with gold catalysis. This review outlines the developments achieved in the past decade, highlighting the modifications that are performed in a sequential or domino fashion with emphasis on major concepts, synthetic applications of the derived products as well as mechanistic aspects.


Archive | 2017

Research Data Supporting "A Lewis-Base Catalysis Approach for the Photoredox Activation of Boronic Acids and Esters"

Fabio Lima; Upendra K. Sharma; Lars Grunenberg; S Debasmita; S Johannsen; Joerg Sedelmeier; Ev Van der Eycken; Steven V. Ley

This data consists of raw NMR spectra used to characterise all compounds described in the above mentioned manuscript


Chemical Society Reviews | 2015

Metal-mediated post-Ugi transformations for the construction of diverse heterocyclic scaffolds

Upendra K. Sharma; Nandini Sharma; Dipak D. Vachhani; Erik V. Van der Eycken


Organic Letters | 2014

Facile access to functionalized spiro[indoline-3,2'-pyrrole]-2,5'-diones via post-Ugi domino Buchwald-Hartwig/Michael reaction.

Nandini Sharma; Zhenghua Li; Upendra K. Sharma; Erik V. Van der Eycken


ACS Catalysis | 2017

Merger of Visible-Light Photoredox Catalysis and C–H Activation for the Room-Temperature C-2 Acylation of Indoles in Batch and Flow

Upendra K. Sharma; Hannes P. L. Gemoets; Felix Schröder; Timothy Noël; Erik V. Van der Eycken

Collaboration


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Erik V. Van der Eycken

Katholieke Universiteit Leuven

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Nandini Sharma

Katholieke Universiteit Leuven

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Zhenghua Li

Katholieke Universiteit Leuven

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Gonghua Song

East China University of Science and Technology

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Yaping Zhao

East China University of Science and Technology

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Debasmita Saha

Katholieke Universiteit Leuven

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Felix Schröder

Katholieke Universiteit Leuven

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Jun Xu

East China University of Science and Technology

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Damien P. Debecker

Université catholique de Louvain

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