Valentina Coia
Sapienza University of Rome
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Featured researches published by Valentina Coia.
American Journal of Human Genetics | 2002
Fulvio Cruciani; Piero Santolamazza; Peidong Shen; Vincent Macaulay; Pedro Moral; Antonel Olckers; David Modiano; Susan Holmes; Giovanni Destro-Bisol; Valentina Coia; Douglas C. Wallace; Peter J. Oefner; Antonio Torroni; Luigi Luca Cavalli-Sforza; Rosaria Scozzari; Peter A. Underhill
The variation of 77 biallelic sites located in the nonrecombining portion of the Y chromosome was examined in 608 male subjects from 22 African populations. This survey revealed a total of 37 binary haplotypes, which were combined with microsatellite polymorphism data to evaluate internal diversities and to estimate coalescence ages of the binary haplotypes. The majority of binary haplotypes showed a nonuniform distribution across the continent. Analysis of molecular variance detected a high level of interpopulation diversity (PhiST=0.342), which appears to be partially related to the geography (PhiCT=0.230). In sub-Saharan Africa, the recent spread of a set of haplotypes partially erased pre-existing diversity, but a high level of population (PhiST=0.332) and geographic (PhiCT=0.179) structuring persists. Correspondence analysis shows that three main clusters of populations can be identified: northern, eastern, and sub-Saharan Africans. Among the latter, the Khoisan, the Pygmies, and the northern Cameroonians are clearly distinct from a tight cluster formed by the Niger-Congo-speaking populations from western, central western, and southern Africa. Phylogeographic analyses suggest that a large component of the present Khoisan gene pool is eastern African in origin and that Asia was the source of a back migration to sub-Saharan Africa. Haplogroup IX Y chromosomes appear to have been involved in such a migration, the traces of which can now be observed mostly in northern Cameroon.
The American Naturalist | 2004
Giovanni Destro-Bisol; Valentina Coia; Ilaria Boschi; Fabio Verginelli; Alessandra Caglià; Vincenzo Lorenzo Pascali; Gabriella Spedini; Francesc Calafell
The Eastern Pygmies from Zaire and Western Pygmies from Cameroon, Congo, and the Central African Republic represent the two principal groups of African Pygmies. In the “recent divergence” hypothesis in which Western Pygmies are thought to be the result of hybridization between the ancestors of Eastern Pygmies and Bantu farmers who penetrated the equatorial belt and came into contact with Pygmies around 2–3 kiloyears ago. On the basis of recent archaeological research in the tropical rain forest, we propose a “pre‐Bantu divergence” hypothesis, which posits the separation between the ancestors of Eastern and Western Pygmies earlier than 18 kiloyears ago. In order to test the two hypotheses, we analyzed the variation of the hypervariable region 1 of the mitochondrial DNA in the Mbenzele, Western Pygmies of the Central African Republic, and compared our results with those of previous mtDNA and Y chromosome studies. Distribution, sequence variation, and age of haplogroups along with genetic distances among populations, estimates of divergence times, and simulations based on the coalescent approach were found to be congruent with the pre‐Bantu divergence but failed to support the recent divergence hypothesis.
American Journal of Human Biology | 2009
Paolo Anagnostou; Cinzia Battaggia; Valentina Coia; Cristian Capelli; Cristina Fabbri; Davide Pettener; Giovanni Destro-Bisol; Donata Luiselli
We investigated the occurrence and intra‐allelic variability of the T‐13910 variant located upstream of the lactase gene in 965 individuals from 20 different locations of Italy and Greece. The T‐13910 frequency ranges from 0.072 (Sardinia) to 0.237 (North‐East Italy), with a statistically significant difference between North‐East Italians and other Italian populations. The comparison of the lactose tolerance predicted by T‐13910 and that assessed by other studies using physiological tests shows a one‐way statistically significant discrepancy that could be due to sampling differences. However, the possible role of other genetic factors underlying lactase persistence is worth exploring. The time of the most recent common ancestor and departures from neutrality of the T‐13910 allele were assessed using three microsatellite loci. Time estimates were found to be congruent with the appearance of dairy farming in Southern Europe and the occurrence of a single introgression event. Robust signals of selection can be observed in North‐East Italy only. We discuss the possible role of cultural traits and genetic history in determining these observed micro‐evolutionary patterns. Am. J. Hum. Biol. 2009.
Genome Biology and Evolution | 2015
Beniamino Trombetta; Eugenia D’Atanasio; Andrea Massaia; Marco Ippoliti; Alfredo Coppa; Francesca Candilio; Valentina Coia; Gianluca Russo; Jean-Michel Dugoujon; Pedro Moral; Nejat Akar; Daniele Sellitto; Guido Valesini; Andrea Novelletto; Rosaria Scozzari; Fulvio Cruciani
Haplogroup E, defined by mutation M40, is the most common human Y chromosome clade within Africa. To increase the level of resolution of haplogroup E, we disclosed the phylogenetic relationships among 729 mutations found in 33 haplogroup DE Y-chromosomes sequenced at high coverage in previous studies. Additionally, we dissected the E-M35 subclade by genotyping 62 informative markers in 5,222 samples from 118 worldwide populations. The phylogeny of haplogroup E showed novel features compared with the previous topology, including a new basal dichotomy. Within haplogroup E-M35, we resolved all the previously known polytomies and assigned all the E-M35* chromosomes to five new different clades, all belonging to a newly identified subhaplogroup (E-V1515), which accounts for almost half of the E-M35 chromosomes from the Horn of Africa. Moreover, using a Bayesian phylogeographic analysis and a single nucleotide polymorphism-based approach we localized and dated the origin of this new lineage in the northern part of the Horn, about 12 ka. Time frames, phylogenetic structuring, and sociogeographic distribution of E-V1515 and its subclades are consistent with a multistep demic spread of pastoralism within north-eastern Africa and its subsequent diffusion to subequatorial areas. In addition, our results increase the discriminative power of the E-M35 haplogroup for use in forensic genetics through the identification of new ancestry-informative markers.
Journal of Human Genetics | 2012
Valentina Coia; Ilaria Boschi; Federica Trombetta; Fabio Cavulli; Francesco Montinaro; Giovanni Destro-Bisol; Stefano Grimaldi; Annaluisa Pedrotti
Although essential for the fine-scale reconstruction of genetic structure, only a few micro-geographic studies have been carried out in European populations. This study analyzes mitochondrial variation (651 bp of the hypervariable region plus 17 single-nucleotide polymorphisms) in 393 samples from nine populations from Trentino (Eastern Italian Alps), a small area characterized by a complex geography and high linguistic diversity. A high level of genetic variation, comparable to geographically dispersed European groups, was observed. We found a difference in the intensity of peopling processes between two longitudinal areas, as populations from the west-central part of the region show stronger signatures of expansion, whereas those from the eastern area are closer to the expectations of a stationary demographic state. This may be explained by geomorphological factors and is also supported by archeological data. Finally, our results reveal a striking difference in the way in which the two linguistically isolated populations are genetically related to the neighboring groups. The Ladin speakers were found to be genetically close to the Italian-speaking populations and differentiated from the other Dolomitic Ladins, whereas the German-speaking Cimbri behave as an outlier, showing signatures of founder effects and low growth rate.
International Journal of Legal Medicine | 2003
Sergio Tofanelli; Ilaria Boschi; Stefania Bertoneri; Valentina Coia; Luca Taglioli; Marcello Giovanni Franceschi; Giovanni Destro-Bisol; Vincenzo Lorenzo Pascali; Giorgio Paoli
A data set of 16 autosomal STRs (the 13 CODIS loci plus HumCD4, HumFES, HumF13A1) was obtained in a sample of 52 unrelated Hutus from Rwanda. Genotypes at all loci met Hardy-Weinberg expectations with the exception of HumCSF1PO. No significant evidence of association across alleles at independent loci was obtained. Statistical parameters demonstrated the forensic usefulness of the analysed systems (combined PE=0.9999996, combined PD=1:2.27×1018). Pairwise comparisons showed that the Hutu gene pool differs substantially from that of other Bantu-speaking populations suggesting the use of ethnic-specific population databases in forensic casework analysis. The introduction of a non-negligible bias was confirmed by calculating the differences between multiple-locus profile frequencies of western and eastern Bantoids using local and non-local reference databases.
Human Biology | 2003
Alessandra Caglià; Sergio Tofanelli; Valentina Coia; Ilaria Boschi; M. Pescarmona; Gabriella Spedini; Vincenzo Lorenzo Pascali; Giorgio Paoli; Giovanni Destro-Bisol
Seven Y-chromosome microsatellite loci (DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, and DYS393) were analyzed in three populations from sub-Saharan Africa: the Bamileke and Ewondo populations from Cameroon and the Hutu from Rwanda. Complete typing was obtained for 112 individuals, and a total of 53 different haplotypes was observed. The single-locus gene diversity, averaged across populations, ranges from 0.100 for the DYS392 locus to 0.610 for the DYS389I locus. The haplotype diversity ranges from 0.832 (Ewondo) to 0.965 (Hutu), with an intermediate value of 0.918 in the Bamileke. The diversity among Bamileke, Ewondo, Hutu, and other sub-Saharan populations selected from the literature was analyzed using both a classical (FST) and a stepwise-based (RST) genetic distance method. The pattern of interpopulational diversity based on FST was congruent with anthropological knowledge, while that based on RST revealed unexpected and unconvincing population affinities. From a practical point of view, our study indicates that Y-chromosome microsatellite data may provide useful information for analyses of interpopulational diversity among sub-Saharan populations if an adequate number of loci and individuals along with an appropriate genetic distance method are used. On a theoretical ground, we propose that the lesser performance of RST compared to FST could be explained by the important role played by genetic drift in shaping the relationships among examined populations.
PLOS ONE | 2013
Marco Capocasa; Cinzia Battaggia; Paolo Anagnostou; Francesco Montinaro; Ilaria Boschi; Gianmarco Ferri; Milena Alù; Valentina Coia; Federica Crivellaro; Giovanni Destro Bisol
The identification of isolation signatures is fundamental to better understand the genetic structure of human populations and to test the relations between cultural factors and genetic variation. However, with current approaches, it is not possible to distinguish between the consequences of long-term isolation and the effects of reduced sample size, selection and differential gene flow. To overcome these limitations, we have integrated the analysis of classical genetic diversity measures with a Bayesian method to estimate gene flow and have carried out simulations based on the coalescent. Combining these approaches, we first tested whether the relatively short history of cultural and geographical isolation of four “linguistic islands” of the Eastern Alps (Lessinia, Sauris, Sappada and Timau) had left detectable signatures in their genetic structure. We then compared our findings to previous studies of European population isolates. Finally, we explored the importance of demographic and cultural factors in shaping genetic diversity among the groups under study. A combination of small initial effective size and continued genetic isolation from surrounding populations seems to provide a coherent explanation for the diversity observed among Sauris, Sappada and Timau, which was found to be substantially greater than in other groups of European isolated populations. Simulations of micro-evolutionary scenarios indicate that ethnicity might have been important in increasing genetic diversity among these culturally related and spatially close populations.
American Journal of Physical Anthropology | 2009
Valentina Coia; Francesca Brisighelli; Francesco Donati; Vincenzo Lorenzo Pascali; Ilaria Boschi; Donata Luiselli; Cinzia Battaggia; Chiara Batini; Luca Taglioli; Fulvio Cruciani; Giorgio Paoli; Cristian Capelli; Gabriella Spedini; Giovanni Destro-Bisol
In this study, we report the genetic variation of autosomal and Y-chromosomal microsatellites in a large Cameroon population dataset (a total of 11 populations) and jointly analyze novel and previous genetic data (mitochondrial DNA and protein coding loci) taking geographic and cultural factors into consideration. The complex pattern of genetic variation of Cameroon can in part be described by contrasting two geographic areas (corresponding to the northern and southern part of the country), which differ substantially in environmental, biological, and cultural aspects. Northern Cameroon populations show a greater within- and among-group diversity, a finding that reflects the complex migratory patterns and the linguistic heterogeneity of this area. A striking reduction of Y-chromosomal genetic diversity was observed in some populations of the northern part of the country (Podokwo and Uldeme), a result that seems to be related to their demographic history rather than to sampling issues. By exploring patterns of genetic, geographic, and linguistic variation, we detect a preferential correlation between genetics and geography for mtDNA. This finding could reflect a female matrimonial mobility that is less constrained by linguistic factors than in males. Finally, we apply the island model to mitochondrial and Y-chromosomal data and obtain a female-to-male migration Nnu ratio that was more than double in the northern part of the country. The combined effect of the propensity to inter-populational admixture of females, favored by cultural contacts, and of genetic drift acting on Y-chromosomal diversity could account for the peculiar genetic pattern observed in northern Cameroon.
PLOS ONE | 2013
Valentina Coia; Marco Capocasa; Paolo Anagnostou; Vincenzo Lorenzo Pascali; Francesca Scarnicci; Ilaria Boschi; Cinzia Battaggia; Federica Crivellaro; Gianmarco Ferri; Milena Alù; Francesca Brisighelli; George B.J. Busby; Cristian Capelli; Frank Maixner; Giovanna Cipollini; Pier Paolo Viazzo; Albert Zink; Giovanni Destro Bisol
Great European mountain ranges have acted as barriers to gene flow for resident populations since prehistory and have offered a place for the settlement of small, and sometimes culturally diverse, communities. Therefore, the human groups that have settled in these areas are worth exploring as an important potential source of diversity in the genetic structure of European populations. In this study, we present new high resolution data concerning Y chromosomal variation in three distinct Alpine ethno-linguistic groups, Italian, Ladin and German. Combining unpublished and literature data on Y chromosome and mitochondrial variation, we were able to detect different genetic patterns. In fact, within and among population diversity values observed vary across linguistic groups, with German and Italian speakers at the two extremes, and seem to reflect their different demographic histories. Using simulations we inferred that the joint effect of continued genetic isolation and reduced founding group size may explain the apportionment of genetic diversity observed in all groups. Extending the analysis to other continental populations, we observed that the genetic differentiation of Ladins and German speakers from Europeans is comparable or even greater to that observed for well known outliers like Sardinian and Basques. Finally, we found that in south Tyroleans, the social practice of Geschlossener Hof, a hereditary norm which might have favored male dispersal, coincides with a significant intra-group diversity for mtDNA but not for Y chromosome, a genetic pattern which is opposite to those expected among patrilocal populations. Together with previous evidence regarding the possible effects of “local ethnicity” on the genetic structure of German speakers that have settled in the eastern Italian Alps, this finding suggests that taking socio-cultural factors into account together with geographical variables and linguistic diversity may help unveil some yet to be understood aspects of the genetic structure of European populations.