Valery N. Charushin

Novel 1-Trifluoromethyl Substituted 1,2-Ethylenediamines and Their use for the Synthesis of Fluoroquinolones

Abstract A common approach to the synthesis of 1-trifluoromethyl-1,2-ethylenediamines was developed. Based on these original building blocks the new derivatives of N -substituted fluoroquinolones bearing the trifluoromethyl group were obtained. Through-space transmitted coupling constants 7 J F–F between the trifluoromethyl group and F-8 were measured in the 19 F NMR spectra of all fluoroquinolones examined and assigned unequivocally by using 19 F{ 19 F} double resonance technique.

Metal Free C-H Functionalization of Aromatics

During the past two decades the classical concept of nucleophilic aromatic substitution (SN Ar) has been complemented with a new synthetic methodology (SN Ar or briefly SN ), enabling one to perform direct functionalization of aromatic C–H bonds and to build new carbon–carbon C(sp)–C(sp), C(sp)– C(sp), and C(sp)–C(sp) or carbon–heteroatom C(sp)–X bonds (X is O–, N–, P–, S–, Si–, halogen) through nucleophilic displacement of hydrogen in aromatic and heteroaromatic compounds.