Vanessa Casas
Autonomous University of Barcelona
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Publication
Featured researches published by Vanessa Casas.
The Journal of Pathology | 2016
Laia Bonjoch; Vanessa Casas; Montserrat Carrascal; Daniel Closa
A frequent complication of acute pancreatitis is the lung damage associated with the systemic inflammatory response. Although various pro‐inflammatory mediators generated at both local and systemic levels have been identified, the pathogenic mechanisms of the disease are still poorly understood. In recent years, exosomes have emerged as a new intercellular communication system able to transfer encapsulated proteins and small RNAs and protect them from degradation. Using an experimental model of taurocholate‐induced acute pancreatitis in rats, we aimed to evaluate the role of exosomes in the extent of the systemic inflammatory response. Induction of pancreatitis increased the concentration of circulating exosomes, which showed a different proteomic profile to those obtained from control animals. A series of tracking experiments using PKH26‐stained exosomes revealed that circulating exosomes effectively reached the alveolar compartment and were internalized by macrophages. In vitro experiments revealed that exosomes obtained under inflammatory conditions activate and polarize these alveolar macrophages towards a pro‐inflammatory phenotype. Interestingly, the proteomic analysis of circulating exosomes during acute pancreatitis suggested a multi‐organ origin with a relevant role for the liver as a source of these vesicles. Tracking experiments also revealed that the liver retains the majority of exosomes from the peritoneal cavity. We conclude that exosomes are involved in the lung damage associated with experimental acute pancreatitis and could be relevant mediators in the systemic effects of pancreatitis. Copyright
Archive | 2016
Pinto. R.; O. Vidal; Vanessa Casas; Joaquín Abián; Montserrat Carrascal
Archive | 2015
Vanessa Casas; Pinto. R.; Àgueda Rodríguez; Santiago Vadillo; Montserrat Carrascal; Joaquín Abián
Archive | 2015
Pinto. R.; Vanessa Casas; Joaquín Abián; Montserrat Carrascal
Archive | 2014
Vital Vialas; Vanessa Casas; Montserrat Carrascal; Joaquín Abián; C. Gil
Archive | 2014
Vanessa Casas; Montserrat Carrascal; José Larrasa; Santiago Vadillo; Joaquín Abián
Archive | 2014
Tien Dung Nguyen; O. Vidal; Oscar Gallardo; Vanessa Casas; Montserrat Carrascal; V. C. Phan; Joaquín Abián
Proteómica: revista de la Sociedad Española de Proteómica | 2012
Vanessa Casas; Montserrat Carrascal; Emili Gelpí; Joaquín Abián
Proteómica: revista de la Sociedad Española de Proteómica | 2011
Vanessa Casas; Montserrat Carrascal; Emili Gelpí; Joaquín Abián
Archive | 2011
Emili Gelpí; Montserrat Carrascal; Oscar Gallardo; Vanessa Casas; Joaquín Abián